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Disclosing the Potential of Fluorinated Ionic Liquids as Interferon-Alpha 2b Delivery Systems

2022-05-28Artigo científico Acesso aberto
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dc.contributor.authorFerreira, Margarida L.
dc.contributor.authorVieira, Nicole S. M.
dc.contributor.authorOliveira, Ana L. S.
dc.contributor.authorAraújo, João M. M.
dc.contributor.authorPereiro, Ana B.
dc.contributor.institutionLAQV@REQUIMTE
dc.contributor.institutionDQ - Departamento de Química
dc.contributor.pblMDPI AG
dc.date.accessioned2022-08-23T22:19:19Z
dc.date.available2022-08-23T22:19:19Z
dc.date.issued2022-05-28
dc.descriptionFunding: This research was funded by FCT/MCTES (Portugal) through grants SFRH/BD/130965/2017 and COVID/BD/151919/2021 (M.L.F.), the contracts of Individual Call to Scientific Employment Stimulus 2020.00835.CEECIND (J.M.M.A.)/2021.01432.CEECIND (A.B.P.) and project PTDC/EQU-EQU/2223/2021. Publisher Copyright: © 2022 by the authors. Licensee MDPI, Basel, Switzerland.
dc.description.abstractInterferon-alpha 2b (IFN-α 2b) is a therapeutic protein used for the treatment of cancer, viral infections, and auto-immune diseases. Its application is hindered by a low bioavailability and instability in the bloodstream, and the search for new strategies for a target delivery and stabilization of IFN-α 2b to improve its therapeutic efficacy is crucial. Fluorinated ionic liquids (FILs) are promising biomaterials that: (i) can form self-assembled structures; (ii) have complete miscibility in water; and (iii) can be designed to have reduced toxicity. The influence of IFN-α 2b in the aggregation behaviour of FILs and the interactions between them were investigated through conductivity and surface tension measurements, and using electron microscopic and spectroscopy techniques to study FILs feasibility as an interferon-alpha 2b delivery system. The results show that the presence of IFN-α 2b influences the aggregation behaviour of FILs and that strong interaction between the two compounds occurs. The protein might not be fully encapsulated by FILs. However, the FIL can be tailored in the future to carry IFN-α 2b by the formation of a conjugate, which prevents the aggregation of this protein. This work constitutes a first step toward the design and development of FIL-based IFN-α 2b delivery systems.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent31
dc.format.extent4792255
dc.identifier.doi10.3390/nano12111851
dc.identifier.issn2079-4991
dc.identifier.otherPURE: 45290444
dc.identifier.otherPURE UUID: 82f0970e-c657-4a29-b2d1-262a58198a87
dc.identifier.otherScopus: 85130698511
dc.identifier.otherWOS: 000809200800001
dc.identifier.otherPubMed: 35683707
dc.identifier.otherPubMedCentral: PMC9181987
dc.identifier.otherORCID: /0000-0002-8648-7539/work/117747585
dc.identifier.urihttp://hdl.handle.net/10362/143212
dc.identifier.urlhttps://www.scopus.com/pages/publications/85130698511
dc.language.isoeng
dc.peerreviewedyes
dc.relationFunding Information: info:eu-repo/grantAgreement/FCT/OE/SFRH%2FBD%2F130965%2F2017/PT
dc.relationinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F50006%2F2020/PT
dc.relationAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
dc.relationAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
dc.subjectaggregation behaviour
dc.subjectdelivery systems
dc.subjectinteractions
dc.subjectionic liquids
dc.subjecttherapeutic proteins
dc.subjectGeneral Chemical Engineering
dc.subjectGeneral Materials Science
dc.subjectSDG 3 - Good Health and Well-being
dc.titleDisclosing the Potential of Fluorinated Ionic Liquids as Interferon-Alpha 2b Delivery Systemsen
dc.typejournal article
degois.publication.issue11
degois.publication.titleNanomaterials
degois.publication.volume12
dspace.entity.typePublication
oaire.awardNumberUIDB/50006/2020
oaire.awardNumberUIDP/50006/2020
oaire.awardTitleAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
oaire.awardTitleAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F50006%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F50006%2F2020/PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccess
relation.isProjectOfPublicationadc84c24-ba1d-4bcd-b753-2128ce9a5faa
relation.isProjectOfPublication4d9a4d40-4803-4f3a-976b-d6eaaef42510
relation.isProjectOfPublication.latestForDiscovery4d9a4d40-4803-4f3a-976b-d6eaaef42510

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