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Hematological evaluation in males with obstructive sleep apnea before and after positive airway pressure

2017-03-01Artigo científico Acesso aberto
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dc.contributor.authorFeliciano, Amélia
dc.contributor.authorLinhas, R.
dc.contributor.authorMarçôa, R.
dc.contributor.authorCysneiros, Ana
dc.contributor.authorMartinho, C.
dc.contributor.authorPalma dos Reis, Roberto
dc.contributor.authorPenque, Deborah
dc.contributor.authorPinto, Paula
dc.contributor.authorBárbara, Cristina
dc.contributor.institutionNOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
dc.contributor.pblElsevier Doyma
dc.date.accessioned2023-01-20T22:09:28Z
dc.date.available2023-01-20T22:09:28Z
dc.date.issued2017-03-01
dc.description.abstractObstructive sleep apnea syndrome (OSAS) is a systemic inflammatory disease associated with cardiovascular consequences. Red blood cell distribution width (RDW), mean platelet volume (MPV), and platelet distribution width (PDW) are recognized biomarkers of cardiovascular morbidity/mortality. Limited data is available on the association between these parameters and OSAS severity and the relationship with positive airway pressure therapy (PAP). In this prospective study of male OSAS patients we analyzed hematological data in order to evaluate their value in predicting OSAS severity, the relationship with sleep parameters, and their behavior under PAP. Seventy-three patients were included (mean age 46.5 years), of which 36 were mild (49.3%), 10 moderate (13.7%), and 27 severe (37%). The mean RDW increased significantly with OSAS severity and showed a positive correlation with respiratory disturbance index and hypoxemic burdens. Additionally, a group of 48 patients (mean age 47.2 years) were submitted to PAP. After six months, red blood cell count, hemoglobin, hematocrit, and platelet count showed a significant decrease (p < 0.0001; p < 0.0001; p = 0.001; p < 0.0001; respectively). Concerning OSAS severity, these parameters also significantly decreased in mild patients (p = 0.003; p = 0.043; p = 0.020; p = 0.014; respectively) but only hemoglobin, hematocrit, and platelet count decreased in severe cases (p < 0.0001; p = 0.008; p = 0.018; respectively). This study demonstrated an association between RDW values and OSAS severity. Moreover, red cell and platelet parameters changed significantly after PAP, supporting its cardiovascular protective effect. RDW may become a simple/inexpensive blood biomarker, making it useful in prioritizing OSAS patients waiting for polysomnography, and red cell and platelet parameters could be useful in PAP follow up.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent8
dc.format.extent631397
dc.identifier.doi10.1016/j.rppnen.2016.12.001
dc.identifier.issn0873-2159
dc.identifier.otherPURE: 2750990
dc.identifier.otherPURE UUID: fe6e68a9-6c07-4913-8e99-d478396925e2
dc.identifier.otherScopus: 85014473503
dc.identifier.otherPubMed: 28153627
dc.identifier.otherWOS: 000396799100004
dc.identifier.urihttp://hdl.handle.net/10362/147883
dc.identifier.urlhttps://www.scopus.com/pages/publications/85014473503
dc.language.isoeng
dc.peerreviewedyes
dc.subjectMPV
dc.subjectOSAS
dc.subjectPAP
dc.subjectPDW
dc.subjectPlatelet parameters
dc.subjectRDW
dc.subjectRed cell parameters
dc.subjectGeneral Medicine
dc.subjectPulmonary and Respiratory Medicine
dc.titleHematological evaluation in males with obstructive sleep apnea before and after positive airway pressureen
dc.typejournal article
degois.publication.firstPage71
degois.publication.issue2
degois.publication.lastPage78
degois.publication.titleRevista Portuguesa de Pneumologia
degois.publication.volume23
dspace.entity.typePublication
rcaap.rightsopenAccess

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