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Molecular versatility of polyproline II helices

2026Recensão Acesso aberto
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dc.contributor.authorC. Seco, Francisco
dc.contributor.authorAmador, Sandro
dc.contributor.authorConzuelo, Felipe
dc.contributor.authorBaptista, Ana C.
dc.contributor.authorMorgado, Leonor
dc.contributor.authorPina, Ana S.
dc.contributor.institutionInstituto de Tecnologia Química e Biológica António Xavier (ITQB)
dc.contributor.institutionDCM - Departamento de Ciência dos Materiais
dc.contributor.institutionCENIMAT-i3N - Centro de Investigação de Materiais (Lab. Associado I3N)
dc.contributor.institutionUCIBIO - Applied Molecular Biosciences Unit
dc.contributor.institutionDQ - Departamento de Química
dc.contributor.pblRSC - Royal Society of Chemistry
dc.date.accessioned2026-07-08T10:13:02Z
dc.date.available2026-07-08T10:13:02Z
dc.date.issued2026
dc.descriptionUIDB/040612/2020, UIDP/040612/2020 Publisher Copyright: This journal is © The Royal Society of Chemistry, 2026
dc.description.abstractThe polyproline II helix is more common as a secondary structure than previously thought. Its significance extends to mediating various protein–protein interactions, both structurally and functionally, in natural systems. This structure is associated with the formation of supramolecular assemblies, which have been investigated for biomimetic applications. In this review, we highlight three examples of polyproline II helix utilization: structurally in collagen and in biomolecular condensates, and as functional motifs in hyperactive antifreeze proteins. The review examines the mechanisms underlying the properties of PPII and consolidates practical design principles for engineering PPII-based assemblies, with an emphasis on sequence composition, residue propensity, and crosslinking strategies that enhance stability and functionality. Additionally, by critically comparing spectroscopic methods (CD, VCD, ROA and NMR) and AI-based prediction tools, we summarize their respective strengths and limitations, providing a practical decision framework for selecting the most suitable characterization techniques for different sample types and research objectives.en
dc.description.versionpublishersversion
dc.description.versioninpress
dc.format.extent2945337
dc.identifier.doi10.1039/d5tb01841b
dc.identifier.issn2050-750X
dc.identifier.otherPURE: 151399469
dc.identifier.otherPURE UUID: efec6fb3-ab24-4676-995f-a5998b423863
dc.identifier.otherScopus: 105027516847
dc.identifier.urihttp://hdl.handle.net/10362/204388
dc.identifier.urlhttps://www.scopus.com/pages/publications/105027516847
dc.language.isoeng
dc.peerreviewedyes
dc.relationinfo:eu-repo/grantAgreement/FCT/Concurso para Atribuição do Estatuto e Financiamento de Laboratórios Associados (LA)/LA%2FP%2F0037%2F2020/PT
dc.relationinfo:eu-repo/grantAgreement/FCT/Concurso de avaliação no âmbito do Programa Plurianual de Financiamento de Unidades de I&D (2017%2F2018) - Financiamento Programático/UIDP%2F50025%2F2020/PT
dc.relationinfo:eu-repo/grantAgreement/FCT/Concurso de avaliação no âmbito do Programa Plurianual de Financiamento de Unidades de I&D (2017%2F2018) - Financiamento Base/UIDB%2F50025%2F2020/PT
dc.relationinfo:eu-repo/grantAgreement/FCT/Concurso para Atribuição do Estatuto e Financiamento de Laboratórios Associados (LA)/LA%2FP%2F0087%2F2020/PT
dc.relationinfo:eu-repo/grantAgreement/FCT/Concurso para Atribuição do Estatuto e Financiamento de Laboratórios Associados (LA)/LA%2FP%2F0140%2F2020/PT
dc.relationinfo:eu-repo/grantAgreement/FCT/Concurso de avaliação no âmbito do Programa Plurianual de Financiamento de Unidades de I&D (2017%2F2018) - Financiamento Base/UIDB%2F04378%2F2020/PT
dc.relationinfo:eu-repo/grantAgreement/FCT/Concurso de avaliação no âmbito do Programa Plurianual de Financiamento de Unidades de I&D (2017%2F2018) - Financiamento Programático/UIDP%2F04378%2F2020/PT
dc.relationinfo:eu-repo/grantAgreement/FCT/CEEC IND4ed/2021.01283.CEECIND%2FCP1657%2FCT0004/PT
dc.relationinfo:eu-repo/grantAgreement/FCT/CEEC IND5ed/2022.05842.CEECIND%2FCP1725%2FCT0001/PT
dc.subjectGeneral Medicine
dc.subjectGeneral Chemistry
dc.subjectBiomedical Engineering
dc.subjectGeneral Materials Science
dc.titleMolecular versatility of polyproline II helicesen
dc.title.subtitlefrom natural proteins to biomimetic materialsen
dc.typereview
degois.publication.titleJournal of Materials Chemistry B
dspace.entity.typePublication
rcaap.rightsopenAccess

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