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POxylated Dendrimer-Based Nano-in-Micro Dry Powder Formulations for Inhalation Chemotherapy

2018-10-01Artigo científico Acesso aberto
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dc.contributor.authorRestani, Rita B.
dc.contributor.authorPires, Rita F.
dc.contributor.authorTolmatcheva, Anna
dc.contributor.authorCabral, Rita
dc.contributor.authorBaptista, Pedro V.
dc.contributor.authorFernandes, Alexandra R.
dc.contributor.authorCasimiro, Teresa
dc.contributor.authorBonifácio, Vasco D. B.
dc.contributor.authorAguiar-Ricardo, Ana
dc.contributor.institutionLAQV@REQUIMTE
dc.contributor.institutionDQ - Departamento de Química
dc.contributor.institutionUCIBIO - Applied Molecular Biosciences Unit
dc.contributor.institutionDCV - Departamento de Ciências da Vida
dc.contributor.pblWiley-VCH Verlag | Wiley Open Access
dc.date.accessioned2019-01-29T23:46:00Z
dc.date.available2019-01-29T23:46:00Z
dc.date.issued2018-10-01
dc.descriptionThis work was supported by the Associate Laboratory for Green Chemistry-LAQV, which is financed by national funds from FCT/MCTES (UID/QUI/50006/2013) and co-financed by the ERDF under the PT2020 Partnership Agreement (POCI-01-0145-FEDER -007265), the Unidade de Cithornncias Biomoleculares Aplicadas UCIBIO-REQUIMTE, which is financed by national funds from FCT/MEC (UID/Multi/04378/2013) and co-financed by the ERDF under the PT2020 Partnership Agreement (POCI-01-0145-FEDER-007728). The authors acknowledge the Ph.D. grants SFRH/BD/66858/2009 (R.B.R.) and SFRH/BD/109006/2015 (R.F.P.). T.C. also acknowledges FCT-Lisbon for the IF/00915/2014 contract.
dc.description.abstractPOxylated polyurea dendrimer (PUREG4OOx48)-based nanoparticles were loaded with paclitaxel (PTX) and doxorubicin (DOX) and micronized with chitosan (CHT) by using supercritical CO2-assisted spray drying (SASD). Respirable, biocompatible, and biodegradable dry powder formulations (DPFs) were produced to effectively transport and deliver the chemotherapeutics with a controlled rate to the deep lung. In vitro studies performed with the use of the lung adenocarcinoma cell line showed that DOX@PUREG4OOx48 nanoparticles were much more cytotoxic than the free drug. Additionally, the DPFs did not show higher cytotoxicity than the respective nanoparticles, and DOX-DPFs showed a higher chemotherapeutic effect than PTX formulations in adenocarcinoma cells.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent8
dc.format.extent1102739
dc.identifier.doi10.1002/open.201800093
dc.identifier.issn2191-1363
dc.identifier.otherPURE: 6194931
dc.identifier.otherPURE UUID: f3571b5b-be1f-4dcd-8d5b-d0ef4150786a
dc.identifier.otherScopus: 85055532518
dc.identifier.otherWOS: 000451210600003
dc.identifier.otherPubMed: 30338202
dc.identifier.otherPubMedCentral: PMC6174550
dc.identifier.otherORCID: /0000-0001-5255-7095/work/54824764
dc.identifier.otherORCID: /0000-0002-2193-1440/work/55498107
dc.identifier.otherORCID: /0000-0003-2054-4438/work/89984025
dc.identifier.otherORCID: /0000-0001-9405-6221/work/207947301
dc.identifier.urihttp://www.scopus.com/inward/record.url?scp=85055532518&partnerID=8YFLogxK
dc.identifier.urlhttps://www.scopus.com/pages/publications/85055532518
dc.language.isoeng
dc.peerreviewedyes
dc.relationSem PDF conforme despacho. info:eu-repo/grantAgreement/FCT/5876/147218/PT
dc.relationinfo:eu-repo/grantAgreement/FCT/5876/147258/PT
dc.relationinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F66858%2F2009/PT
dc.relationGREEN SYNTHESIS OF FUNCTIONAL POLYMER MICRODEVICES
dc.subjectchemotherapy
dc.subjectcomposite particles
dc.subjectdendrimers
dc.subjectdrug delivery
dc.subjectpulmonary delivery
dc.subjectGeneral Chemistry
dc.titlePOxylated Dendrimer-Based Nano-in-Micro Dry Powder Formulations for Inhalation Chemotherapyen
dc.typejournal article
degois.publication.firstPage772
degois.publication.issue10
degois.publication.lastPage779
degois.publication.titleChemistryOpen
degois.publication.volume7
dspace.entity.typePublication
oaire.awardNumberUID/Multi/04378/2013
oaire.awardNumberSFRH/BD/66858/2009
oaire.awardTitleGREEN SYNTHESIS OF FUNCTIONAL POLYMER MICRODEVICES
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FMulti%2F04378%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F66858%2F2009/PT
oaire.fundingStream5876
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccess
relation.isProjectOfPublicationf6c6102f-c577-4633-a70c-08a0b27e1207
relation.isProjectOfPublication21d75392-92e9-4572-948f-77b3fadb338e
relation.isProjectOfPublication.latestForDiscovery21d75392-92e9-4572-948f-77b3fadb338e

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