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Implementação e validação de novos marcadores para diagnóstico de doença arterial e rápida evolução do risco cardiovascular
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As doenças cardiovasculares são uma das principais causas da mortalidade a nível mundial, com tendência a aumentar nos próximos anos. De forma a prever o impacto destas doenças, têm sido investigados os principais indicadores de risco Cardiovascular (CV), tais como a pressão e a rigidez arteriais, que estão correlacionadas com vários fatores de risco, entre eles o envelhecimento, o sedentarismo, a obesidade, hábitos tabágicos, diabetes e dislipidemia. O principal objetivo deste trabalho consistiu na implementação e validação de um novo marcador da rigidez arterial, o Cardio-Ankle Vascular Index (CAVI). Para isso, foi desenvolvido um novo software, assim como e a interface do utilizador, para teste e validação do equipamento. A validação do CAVI foi efetuada contra o dispositivo VaSeraTM, nas instalações do Hospital do Espírito Santo e Évora e da NOVA School of Science and Technology, numa amostra saudável de 90 indivíduos, distribuídos por três faixas etárias (18−30; 31−60; > 61). Obteve-se uma diferença média entre os dispositivos de 0,41 ± 1,46, e tendo-se verificado uma correlação estatística entre os dois métodos analisados. A Pressão Arterial Central (PAC) foi também validada no VasoCheck® contra o dispositivo SphygmoCor ®, nas instalações do Hospital Senhora da Oliveira de Guimarães, numa amostra de 67 voluntários, distribuídos pelas mesmas faixas etárias mencionadas anteriormente. Para este estudo obteve-se uma diferença média entre os valores recolhidos pelos dois métodos de 0,89 ± 6,18 mmHg. A Velocidade da Onda de Pulso (VOP), validada em estudos anteriores no equipamento VasoCheck®, foi neste estudo correlacionada com a presença de doenças reumáticas e com o envelhecimento. O desenvolvimento e validação da PAC, VOP e CAVI conjuga os principais indicadores de rigidez e pressão arterial num só equipamento, o VasoCheck®, permitindo a sua introdução na prática clínica, como um dispositivo de baixo custo, de simples utilização, confortável para o paciente, uma vez que é sem fios, e bastante completo na análise do risco cardiovascular.
Cardiovascular diseases are one of the leading causes of mortality worldwide, with a tendency to increase in the coming years. In order to predict the impact of these diseases, the main CV risk indicators have been investigated, such as arterial pressure and stiffness, which are correlated with various risk factors, including aging, sedentary lifestyle, obesity, smoking habits, diabetes, and dyslipidemia. The main objective of this work was to implement and validate a new marker of arterial stiffness, the Cardio-Ankle Vascular Index CAVI. For this, a new software and user interface were developed for testing and validation of the equipment. The validation of CAVI was performed against the VaSeraTM device at the Hospital do Espírito Santo in Évora and the NOVA School of Science and Technology, in a healthy sample of 90 individuals, distributed across three age groups (18-30; 31-60; >61). A mean difference of 0,41 ± 1,46 was obtained between the devices, and a statistical correlation was found between the two analysed methods. PAC was also validated in the VasoCheck® against the SphygmoCor® device at the Hospital Senhora da Oliveira de Guimarães, in a sample of 67 volunteers, distributed across the same age groups mentioned above. For this study, a mean difference of 0,89 ± 6,18 mmHg was obtained between the values collected by the two methods. Pulse Wave Velocity (PWV), validated in previous studies using the VasoCheck® equipment, was correlated in this study with the presence of rheumatic diseases and aging. The development and validation of PAC, PWV, and CAVI combine the main indicators of arterial stiffness and pressure in a single equipment, the VasoCheck®, allowing its introduction into clinical practice as a low-cost, easy-to-use, comfortable for the patient, since it is wireless, and comprehensive in cardiovascular risk analysis device.
Cardiovascular diseases are one of the leading causes of mortality worldwide, with a tendency to increase in the coming years. In order to predict the impact of these diseases, the main CV risk indicators have been investigated, such as arterial pressure and stiffness, which are correlated with various risk factors, including aging, sedentary lifestyle, obesity, smoking habits, diabetes, and dyslipidemia. The main objective of this work was to implement and validate a new marker of arterial stiffness, the Cardio-Ankle Vascular Index CAVI. For this, a new software and user interface were developed for testing and validation of the equipment. The validation of CAVI was performed against the VaSeraTM device at the Hospital do Espírito Santo in Évora and the NOVA School of Science and Technology, in a healthy sample of 90 individuals, distributed across three age groups (18-30; 31-60; >61). A mean difference of 0,41 ± 1,46 was obtained between the devices, and a statistical correlation was found between the two analysed methods. PAC was also validated in the VasoCheck® against the SphygmoCor® device at the Hospital Senhora da Oliveira de Guimarães, in a sample of 67 volunteers, distributed across the same age groups mentioned above. For this study, a mean difference of 0,89 ± 6,18 mmHg was obtained between the values collected by the two methods. Pulse Wave Velocity (PWV), validated in previous studies using the VasoCheck® equipment, was correlated in this study with the presence of rheumatic diseases and aging. The development and validation of PAC, PWV, and CAVI combine the main indicators of arterial stiffness and pressure in a single equipment, the VasoCheck®, allowing its introduction into clinical practice as a low-cost, easy-to-use, comfortable for the patient, since it is wireless, and comprehensive in cardiovascular risk analysis device.
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Rigidez arterial doenças cardiovasculares pressão arterial envelhecimento