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Rotavirus A infection in pre- and post-vaccine period

2021-08-06Recensão Acesso aberto
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dc.contributor.authorChissaque, Assucênio
dc.contributor.authorBauhofer, Adilson Fernando Loforte
dc.contributor.authorCossa-Moiane, Idalecia
dc.contributor.authorSitoe, Ezequias
dc.contributor.authorMunlela, Benilde
dc.contributor.authorJoão, Eva Dora
dc.contributor.authorLanga, Jeronimo S.
dc.contributor.authorChilaule, Jorfelia Jose
dc.contributor.authorBoene, Simone Salvador
dc.contributor.authorCassocera, Marta
dc.contributor.authorLourenço Guimarães, Esperança
dc.contributor.authorKellogg, Timothy A.
dc.contributor.authorGoncalves, Luzia
dc.contributor.authorDe Deus, Nilsa
dc.contributor.institutionInstituto de Higiene e Medicina Tropical (IHMT)
dc.contributor.institutionPopulation health, policies and services (PPS)
dc.contributor.institutionGlobal Health and Tropical Medicine (GHTM)
dc.contributor.pblPLOS - Public Library of Science
dc.date.accessioned2021-09-23T01:07:29Z
dc.date.available2021-09-23T01:07:29Z
dc.date.issued2021-08-06
dc.descriptionPublisher Copyright: © 2021 Chissaque et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
dc.description.abstractMozambique introduced the monovalent rotavirus vaccine (Rotarix®, GSK Biologicals, Rixensart, Belgium) in September 2015. Previous analysis, showed that Nampula province continues reporting a high frequency of Rotavirus A (RVA) infection and the emergence of G9P[6], G9P[4] and G3P[4] genotypes. This analysis aimed to determine the RVA frequency; risk factors; genotype distribution by vaccination status and age between pre- and post-vaccine periods in children under-five years old with diarrhea in Nampula. A cross-sectional, hospital-based surveillance study was conducted in the Hospital Central de Nampula in Mozambique. Socio-demographic and clinical data were collected to assess factors related to RVA infection in both periods. Stool specimens were screened to detect RVA by ELISA, and positive samples were genotyped. Between 2015 (pre-vaccine period) and 2016-2019 (post-vaccine period), 614 stool specimens were collected and tested for RVA in which 34.9% (67/192) were positive in pre-vaccine period and 21.8% (92/422) in post-vaccine (p = 0.001). In the post-vaccine period, age, year, and contact with different animal species (chicken, duck, or multiple animals) were associated with RVA infection. RVA infection was higher in children partially vaccinated (40.7%, 11/27) followed by the fully vaccinated (29.3%, 56/191) and the unvaccinated (15.3%, 21/137) (p = 0.002). G1P[8] and G9P[4] were common in vaccinated children less than 12 months. The present analysis showed that RVA infection reduced slightly in the post-vaccine period, with a high proportion of infection and genotype diversity in children, under 12 months of age, vaccinated. Further research on factors associated with RVA infection on vaccinated compared to unvaccinated children and vaccination optimization should be done.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent17
dc.format.extent1018758
dc.identifier.doi10.1371/journal.pone.0255720
dc.identifier.issn1932-6203
dc.identifier.otherPURE: 33791137
dc.identifier.otherPURE UUID: ebbdb72a-a4c7-4c3f-89e4-dcc464872225
dc.identifier.otherScopus: 85112631253
dc.identifier.otherPubMed: 34358275
dc.identifier.otherPubMedCentral: PMC8345880
dc.identifier.urihttp://hdl.handle.net/10362/125035
dc.identifier.urlhttps://www.scopus.com/pages/publications/85112631253
dc.language.isoeng
dc.peerreviewedyes
dc.subjectrotavirus
dc.subjectvaccine
dc.subjectInfectious Diseases
dc.subjectGenetics
dc.subjectPublic Health, Environmental and Occupational Health
dc.subjectBiochemistry, Genetics and Molecular Biology (miscellaneous)
dc.subjectImmunology and Microbiology (miscellaneous)
dc.subjectVirology
dc.subjectPediatrics, Perinatology, and Child Health
dc.subjectEpidemiology
dc.subjectHealth Policy
dc.subjectSDG 1 - No Poverty
dc.subjectSDG 2 - Zero Hunger
dc.subjectSDG 3 - Good Health and Well-being
dc.subjectSDG 5 - Gender Equality
dc.subjectSDG 6 - Clean Water and Sanitation
dc.subjectSDG 10 - Reduced Inequalities
dc.subjectSDG 11 - Sustainable Cities and Communities
dc.subjectSDG 16 - Peace, Justice and Strong Institutions
dc.subjectSDG 17 - Partnerships for the Goals
dc.titleRotavirus A infection in pre- and post-vaccine perioden
dc.title.subtitleRisk factors, genotypes distribution by vaccination status and age of children in Nampula Province, Northern Mozambique (2015-2019)en
dc.typereview
degois.publication.firstPage1
degois.publication.issue8
degois.publication.lastPage17
degois.publication.titlePLoS ONE
degois.publication.volume16
dspace.entity.typePublication
rcaap.rightsopenAccess

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