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The pleiotropic CLEC10A

2024Recensão Acesso aberto
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dc.contributor.authorvan der Meijs, Nadia L.
dc.contributor.authorTravecedo, Maria Alejandra
dc.contributor.authorMarcelo, Filipa
dc.contributor.authorvan Vliet, Sandra J.
dc.contributor.institutionUCIBIO - Applied Molecular Biosciences Unit
dc.contributor.pblTaylor & Francis
dc.date.accessioned2025-03-13T21:13:25Z
dc.date.available2025-03-13T21:13:25Z
dc.date.issued2024
dc.descriptionPublisher Copyright: © 2024 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.
dc.description.abstractIntroduction: CLEC10A is a C-type lectin receptor that specifically marks the conventional dendritic cell subsets two and three (cDC2 and DC3). It has a unique recognition profile of glycan antigens, with terminal N-Acetylgalactosamine residues that are frequently present in the tumor microenvironment. Even though CLEC10A expression allows for precise targeting of cDC2 and DC3 for the treatment of cancer, CLEC10A signaling has also been associated with anti-inflammatory responses that would promote tumor growth. Areas covered: Here, we review the potential benefits and drawbacks of CLEC10A engagement in the tumor microenvironment. We discuss the CLEC10A-mediated effects in different cell types and incorporate the pleiotropic effects of IL-10, the main anti-inflammatory response upon CLEC10A binding. Expert opinion: To translate this to a successful CLEC10A-mediated immunotherapy with limited tumor-promoting capacities, finding the right ligand presentation and adjuvant combination will be key.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent12
dc.format.extent5007386
dc.identifier.doi10.1080/14728222.2024.2374743
dc.identifier.issn1472-8222
dc.identifier.otherPURE: 106848318
dc.identifier.otherPURE UUID: 77636323-4f80-456b-919f-d329f426fc2f
dc.identifier.otherScopus: 85197467261
dc.identifier.otherPubMed: 38946482
dc.identifier.urihttp://hdl.handle.net/10362/180582
dc.identifier.urlhttps://www.scopus.com/pages/publications/85197467261
dc.language.isoeng
dc.peerreviewedyes
dc.subjectC-type lectin
dc.subjectCLEC10A
dc.subjectDendritic cells
dc.subjectglycobiology
dc.subjectMacrophage galactose-type lectin
dc.subjecttumor microenvironment
dc.subjectMolecular Medicine
dc.subjectPharmacology
dc.subjectDrug Discovery
dc.subjectClinical Biochemistry
dc.subjectSDG 3 - Good Health and Well-being
dc.titleThe pleiotropic CLEC10Aen
dc.title.subtitleimplications for harnessing this receptor in the tumor microenvironmenten
dc.typereview
degois.publication.firstPage601
degois.publication.issue7
degois.publication.lastPage612
degois.publication.titleExpert Opinion on Therapeutic Targets
degois.publication.volume28
dspace.entity.typePublication
rcaap.rightsopenAccess

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