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Detection of Enteric Viruses in Children under Five Years of Age before and after Rotavirus Vaccine Introduction in Manhiça District, Southern Mozambique, 2008–2019

2024-07Artigo científico Acesso aberto
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dc.contributor.authorChirinda, Percina
dc.contributor.authorManjate, Filomena
dc.contributor.authorGarrine, Marcelino
dc.contributor.authorMessa, Augusto
dc.contributor.authorNobela, Nélio
dc.contributor.authorVubil, Delfino
dc.contributor.authorNhampossa, Tacilta
dc.contributor.authorAcácio, Sozinho
dc.contributor.authorBassat, Quique
dc.contributor.authorKotloff, Karen L.
dc.contributor.authorLevine, Myron M.
dc.contributor.authorNataro, James P.
dc.contributor.authorTate, Jacqueline E.
dc.contributor.authorParashar, Umesh
dc.contributor.authorMwenda, Jason M.
dc.contributor.authorAlonso, Pedro L.
dc.contributor.authorJoão, Eva D.
dc.contributor.authorMandomando, Inácio
dc.contributor.institutionGlobal Health and Tropical Medicine (GHTM)
dc.contributor.institutionInstituto de Higiene e Medicina Tropical (IHMT)
dc.contributor.institutionLaboratório Associado de Translacção e Inovação para a Saúde Global - LA Real (Pólo IHMT)
dc.contributor.institutionTB, HIV and opportunistic diseases and pathogens (THOP)
dc.contributor.pblMDPI - Multidisciplinary Digital Publishing Institute
dc.date.accessioned2024-10-07T22:25:13Z
dc.date.available2024-10-07T22:25:13Z
dc.date.issued2024-07
dc.description:840-15 SC); The United States Agency for International Development (USAID), and Fundo Nacional de Investiga\u00E7\u00E3o (FNI), Mo\u00E7ambique. ISGlobal acknowledges support from the grant CEX2018-000806-S funded by MCIN/AEI/10.13039/501100011033 and support from the Generalitat de Catalunya through the CERCA Program. CISM is supported by the Government of Mozambique and the Spanish Agency for International Development (AECID). Publisher Copyright: © 2024 by the authors.
dc.description.abstractEnteric viruses are the leading cause of diarrhoea in children <5 years. Despite existing studies describing rotavirus diarrhoea in Mozambique, data on other enteric viruses remains scarce, especially after rotavirus vaccine introduction. We explored the prevalence of norovirus GI and GII, adenovirus 40/41, astrovirus, and sapovirus in children <5 years with moderate-to-severe (MSD), less severe (LSD) diarrhoea and community healthy controls, before (2008–2012) and after (2016–2019) rotavirus vaccine introduction in Manhiça District, Mozambique. The viruses were detected using ELISA and conventional reverse transcription PCR from stool samples. Overall, all of the viruses except norovirus GI were significantly more detected after rotavirus vaccine introduction compared to the period before vaccine introduction: norovirus GII in MSD (13/195, 6.7% vs. 24/886, 2.7%, respectively; p = 0.006) and LSD (25/268, 9.3% vs. 9/430, 2.1%, p < 0.001); adenovirus 40/41 in MSD (7.2% vs. 1.8%, p < 0.001); astrovirus in LSD (7.5% vs. 2.6%, p = 0.002); and sapovirus in MSD (7.1% vs. 1.4%, p = 0.047) and controls (21/475, 4.4% vs. 51/2380, 2.1%, p = 0.004). Norovirus GII, adenovirus 40/41, astrovirus, and sapovirus detection increased in MSD and LSD cases after rotavirus vaccine introduction, supporting the need for continued molecular surveillance for the implementation of appropriate control and prevention measures.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent1090665
dc.identifier.doi10.3390/v16071159
dc.identifier.issn1999-4915
dc.identifier.otherPURE: 100775714
dc.identifier.otherPURE UUID: c55cc76f-0a70-425b-a0fd-a9d086a885b8
dc.identifier.otherScopus: 85199651966
dc.identifier.otherWOS: 001278815900001
dc.identifier.otherPubMed: 39066321
dc.identifier.otherPubMedCentral: PMC11281453
dc.identifier.urihttp://hdl.handle.net/10362/173125
dc.identifier.urlhttps://www.scopus.com/pages/publications/85199651966
dc.language.isoeng
dc.peerreviewedyes
dc.relationFunding Information: The Bill & Melinda Gates Foundation (OPP1033572), through the Center for Vaccine Development, USA, funded the GEMS study. The diarrhoeal disease platform was supported by GAVI through the Centers for Disease Control and Prevention (CDC), Atlanta and World Health Organization, Regional Office for Africa (WHO/AFRO) (MOA
dc.subjectchildren
dc.subjectdiarrhoea
dc.subjectenteric viruses
dc.subjectMozambique
dc.subjectrotavirus vaccine
dc.subjectInfectious Diseases
dc.subjectVirology
dc.subjectSDG 3 - Good Health and Well-being
dc.titleDetection of Enteric Viruses in Children under Five Years of Age before and after Rotavirus Vaccine Introduction in Manhiça District, Southern Mozambique, 2008–2019en
dc.typejournal article
degois.publication.issue7
degois.publication.titleViruses
degois.publication.volume16
dspace.entity.typePublication
rcaap.rightsopenAccess

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