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Prevalence of undiagnosed rheumatic and musculoskeletal diseases and its association with health-related quality of life and with physical function

2023-01Artigo científico Acesso aberto
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dc.contributor.authorPina Gonçalves, Nuno
dc.contributor.authorAzeredo, Sofia
dc.contributor.authorMucharreira de Azeredo Lopes, Sofia
dc.contributor.authorSepriano, Alexandre
dc.contributor.authorSepriano, Alexandre
dc.contributor.authorHenriques, Ana Rita
dc.contributor.authorOliveira Henriques, Ana Rita
dc.contributor.authorPires, Tomás
dc.contributor.authorBranco, Jaime
dc.contributor.authorBranco, Jaime
dc.contributor.authorCanhão, Helena
dc.contributor.authorCanhão, Helena
dc.contributor.authorRodrigues, Ana M
dc.contributor.authorMaria Rodrigues, Ana
dc.contributor.institutionComprehensive Health Research Centre (CHRC) - pólo NMS
dc.contributor.institutionNOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
dc.contributor.pblSociedade Portuguesa de Reumatologia
dc.date.accessioned2023-05-04T22:12:34Z
dc.date.available2023-05-04T22:12:34Z
dc.date.issued2023-01
dc.description.abstractAIM: To estimate the disease specific prevalence of undiagnosed rheumatic and musculoskeletal diseases (RMDs) in Portugal and determine if people with undiagnosed RMDs have worse quality of life, physical function and higher health resources consumption, than people without RMDs. METHODS: A subgroup analysis of EpiReumaPt was made that included all participants≥18 years evaluated by a rheumatologist. Participants were stratified into three groups: undiagnosed RMDs; previously diagnosed RMDs; non-RMDs. A descriptive analysis of the three groups was performed. To estimate the prevalence of undiagnosed RMDs, weighted proportion were computed considering the sample design. The three groups were compared (Undiagnosed RMDs vs non-RMDs; Previously diagnosed RMDs vs non-RMDs) for health related quality of life (HRQoL) (EQ5D), physical function (HAQ), mental health (HADS) and health resources consumption. The effect of being undiagnosed for these outcomes was assessed in multivariable models adjusted for age, gender, geographical region and years of education (reference: non-RMD). RESULTS: A total of 3877 participants were included. The prevalence of undiagnosed RMDs was 29%. Compared to participants without RMDs, undiagnosed participants had lower HRQoL (EQ-5D: β (95% CI)=-0.07 (-0.103,-0.043)) and physical function (HAQ: β (95% CI)=0.10 (0.05, 0.15)), more anxiety (OR (95% CI)=2.3 (1.4, 3.7)) and depression symptoms (OR (95% CI)=1.4 (0.8, 2.4)). Undiagnosed RMDs participants were more likely to visit an orthopedist (OR (95% CI)=2.0 (1.1, 3.5)) and had a higher number of orthopedic appointments (IRR (95% CI)=2.5 (1.3, 4.9)) than participants without RMDs. CONCLUSION: Patients with undiagnosed RMDs are frequent in Portugal, have worse HRQoL, physical function and mental health than people without RMDs. Undiagnosed patients are nonetheless consumers of health resources and tend to seek help from specialties other than rheumatology. Increasing the awareness of RMDs might promote their early identification and treatment leading to both personal and societal benefits.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent490777
dc.identifier.issn2795-4552
dc.identifier.otherPURE: 54535372
dc.identifier.otherPURE UUID: a53d3e71-4fab-49f7-8f3f-df003dba24cd
dc.identifier.otherPubMed: 36739530
dc.identifier.otherScopus: 85153945906
dc.identifier.otherWOS: 000957044800002
dc.identifier.otherORCID: /0000-0003-1894-4870/work/151431047
dc.identifier.urihttp://hdl.handle.net/10362/152433
dc.identifier.urlhttps://pubmed.ncbi.nlm.nih.gov/36739530/
dc.language.isoeng
dc.peerreviewedyes
dc.subjectDepression
dc.subjectEpidemiology
dc.subjectHealth economics
dc.subjectHealth policies
dc.subjectQuality of health care
dc.subjectQuality of life
dc.subjectSDG 3 - Good Health and Well-being
dc.titlePrevalence of undiagnosed rheumatic and musculoskeletal diseases and its association with health-related quality of life and with physical functionen
dc.typejournal article
degois.publication.firstPage7
degois.publication.issue1
degois.publication.lastPage16
degois.publication.titleARP rheumatology
degois.publication.volume2
dspace.entity.typePublication
person.familyNameMucharreira de Azeredo Lopes
person.familyNameSepriano
person.familyNameOliveira Henriques
person.familyNameBranco
person.familyNameCanhão
person.familyNameRodrigues
person.givenNameSofia
person.givenNameAlexandre
person.givenNameAna Rita
person.givenNameJaime
person.givenNameHelena
person.givenNameAna Maria
person.identifier1741554
person.identifier397398
person.identifier379800
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person.identifier.ciencia-id0710-586F-985D
person.identifier.ciencia-id5E1B-9976-5CE4
person.identifier.ciencia-id9517-0DAE-E511
person.identifier.ciencia-idB612-E5C3-60DC
person.identifier.ciencia-id5A17-C6D9-DBC8
person.identifier.ciencia-idAE18-DA10-460C
person.identifier.orcid0000-0002-4655-4987
person.identifier.orcid0000-0003-1954-0229
person.identifier.orcid0000-0003-4581-0843
person.identifier.orcid0000-0001-7024-4375
person.identifier.orcid0000-0003-1894-4870
person.identifier.orcid0000-0003-2046-8017
person.identifier.ridC-9611-2018
person.identifier.scopus-author-id55266526300
person.identifier.scopus-author-id8417815400
person.identifier.scopus-author-id6602393492
person.identifier.scopus-author-id57189499663
rcaap.rightsopenAccess
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