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The immune microenvironment in multiple myeloma

2021-02-02Recensão Acesso aberto
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dc.contributor.authorLopes, Raquel
dc.contributor.authorCaetano, Joana
dc.contributor.authorFerreira, Bruna
dc.contributor.authorBarahona, Filipa
dc.contributor.authorCarneiro, Emilie Arnault
dc.contributor.authorJoão, Cristina
dc.contributor.institutionNOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
dc.contributor.pblMDPI - Multidisciplinary Digital Publishing Institute
dc.date.accessioned2021-02-23T00:04:02Z
dc.date.available2021-02-23T00:04:02Z
dc.date.issued2021-02-02
dc.descriptionFunding: This research was funded by Fundação para a Ciência e Tecnologia (FCT), PTDC/MECHEM/30315/2017.
dc.description.abstractMultiple myeloma (MM) is one of the most prevalent hematological cancers worldwide, characterized by the clonal expansion of neoplastic plasma cells in the bone marrow (BM). A combination of factors is implicated in disease progression, including BM immune microenvironment changes. Increasing evidence suggests that the disruption of immunological processes responsible for myeloma control ultimately leads to the escape from immune surveillance and resistance to immune effector function, resulting in an active form of myeloma. In fact, one of the hallmarks of MM is the development of a permissive BM milieu that provides a growth advantage to the malignant cells. Consequently, a better understanding of how myeloma cells interact with the BM niche com-partments and disrupt the immune homeostasis is of utmost importance to develop more effective treatments. This review focuses on the most up-to-date knowledge regarding microenvironment-related mechanisms behind MM immune evasion and suppression, as well as promising molecules that are currently under pre-clinical tests targeting immune populations.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent16
dc.format.extent1019039
dc.identifier.doi10.3390/cancers13040625
dc.identifier.issn2072-6694
dc.identifier.otherPURE: 28096463
dc.identifier.otherPURE UUID: d252dde5-e277-4c21-8f24-eb3f58272cf2
dc.identifier.otherScopus: 85100459602
dc.identifier.otherWOS: 000623357700001
dc.identifier.otherPubMed: 33562441
dc.identifier.urihttp://hdl.handle.net/10362/112276
dc.identifier.urlhttps://www.scopus.com/pages/publications/85100459602
dc.language.isoeng
dc.peerreviewedyes
dc.subjectCancer immunity
dc.subjectImmunotherapy
dc.subjectMultiple myeloma
dc.subjectTumor microenvironment
dc.subjectOncology
dc.subjectCancer Research
dc.subjectSDG 3 - Good Health and Well-being
dc.titleThe immune microenvironment in multiple myelomaen
dc.title.subtitleFriend or foe?en
dc.typereview
degois.publication.firstPage1
degois.publication.issue4
degois.publication.lastPage16
degois.publication.titleCancers
degois.publication.volume13
dspace.entity.typePublication
rcaap.rightsopenAccess

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