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Global expansion of Mycobacterium tuberculosis lineage 4 shaped by colonial migration and local adaptation

2018-10-17Artigo científico Acesso aberto
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dc.contributor.authorBrynildsrud, Ola B.
dc.contributor.authorPepperell, Caitlin S.
dc.contributor.authorSuffys, Philip
dc.contributor.authorGrandjean, Louis
dc.contributor.authorMonteserin, Johana
dc.contributor.authorDebech, Nadia
dc.contributor.authorBohlin, Jon
dc.contributor.authorAlfsnes, Kristian
dc.contributor.authorPettersson, John O.H.
dc.contributor.authorKirkeleite, Ingerid
dc.contributor.authorFandinho, Fatima
dc.contributor.authorda Silva, Marcia Aparecida
dc.contributor.authorPerdigao, Joao
dc.contributor.authorPortugal, Isabel
dc.contributor.authorViveiros, Miguel
dc.contributor.authorClark, Taane
dc.contributor.authorCaws, Maxine
dc.contributor.authorDunstan, Sarah
dc.contributor.authorThai, Phan Vuong Khac
dc.contributor.authorLopez, Beatriz
dc.contributor.authorRitacco, Viviana
dc.contributor.authorKitchen, Andrew
dc.contributor.authorBrown, Tyler S.
dc.contributor.authorvan Soolingen, Dick
dc.contributor.authorO'Neill, Mary B.
dc.contributor.authorHolt, Kathryn E.
dc.contributor.authorFeil, Edward J.
dc.contributor.authorMathema, Barun
dc.contributor.authorBalloux, Francois
dc.contributor.authorEldholm, Vegard
dc.contributor.institutionTB, HIV and opportunistic diseases and pathogens (THOP)
dc.contributor.institutionInstituto de Higiene e Medicina Tropical (IHMT)
dc.contributor.institutionGlobal Health and Tropical Medicine (GHTM)
dc.contributor.pblAmerican Association for the Advancement of Science
dc.date.accessioned2021-05-02T22:39:43Z
dc.date.available2021-05-02T22:39:43Z
dc.date.issued2018-10-17
dc.description.abstractOn the basis of population genomic and phylogeographic analyses of 1669 Mycobacterium tuberculosis lineage 4 (L4) genomes, we find that dispersal of L4 has been completely dominated by historical migrations out of Europe. We demonstrate an intimate temporal relationship between European colonial expansion into Africa and the Americas and the spread of L4 tuberculosis (TB). Markedly, in the age of antibiotics, mutations conferring antimicrobial resistance overwhelmingly emerged locally (at the level of nations), with minimal cross-border transmission of resistance. The latter finding was found to reflect the relatively recent emergence of these mutations, as a similar degree of local restriction was observed for susceptible variants emerging on comparable time scales. The restricted international transmission of drug-resistant TB suggests that containment efforts at the level of individual countries could be successful.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent11
dc.format.extent820227
dc.identifier.doi10.1126/sciadv.aat5869
dc.identifier.issn2375-2548
dc.identifier.otherPURE: 6121568
dc.identifier.otherPURE UUID: 3dee6c16-1b3b-4fb4-8431-cc2509859066
dc.identifier.otherScopus: 85055073936
dc.identifier.otherPubMed: 30345355
dc.identifier.otherPubMedCentral: PMC6192687
dc.identifier.otherORCID: /0000-0001-9676-6251/work/53556494
dc.identifier.urihttp://hdl.handle.net/10362/116688
dc.identifier.urlhttps://www.scopus.com/pages/publications/85055073936
dc.language.isoeng
dc.peerreviewedyes
dc.subjectBiochemistry, Genetics and Molecular Biology (miscellaneous)
dc.subjectEcology, Evolution, Behavior and Systematics
dc.subjectInfectious Diseases
dc.subjectSDG 3 - Good Health and Well-being
dc.titleGlobal expansion of Mycobacterium tuberculosis lineage 4 shaped by colonial migration and local adaptationen
dc.typejournal article
degois.publication.firstPage
degois.publication.issue10
degois.publication.lastPage
degois.publication.titleScience Advances
degois.publication.volume4
dspace.entity.typePublication
rcaap.rightsopenAccess

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