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Pupillometry as a reliable metric of auditory detection and discrimination across diverse stimulus paradigms in animal models

2021-02-04Artigo científico Acesso aberto
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dc.contributor.authorMontes-Lourido, Pilar
dc.contributor.authorKar, Manaswini
dc.contributor.authorKumbam, Isha
dc.contributor.authorSadagopan, Srivatsun
dc.contributor.institutionNOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
dc.contributor.institutionCentro de Estudos de Doenças Crónicas (CEDOC)
dc.contributor.pblNature Publishing Group
dc.date.accessioned2021-02-23T00:04:00Z
dc.date.available2021-02-23T00:04:00Z
dc.date.issued2021-02-04
dc.description.abstractEstimates of detection and discrimination thresholds are often used to explore broad perceptual similarities between human subjects and animal models. Pupillometry shows great promise as a non-invasive, easily-deployable method of comparing human and animal thresholds. Using pupillometry, previous studies in animal models have obtained threshold estimates to simple stimuli such as pure tones, but have not explored whether similar pupil responses can be evoked by complex stimuli, what other stimulus contingencies might affect stimulus-evoked pupil responses, and if pupil responses can be modulated by experience or short-term training. In this study, we used an auditory oddball paradigm to estimate detection and discrimination thresholds across a wide range of stimuli in guinea pigs. We demonstrate that pupillometry yields reliable detection and discrimination thresholds across a range of simple (tones) and complex (conspecific vocalizations) stimuli; that pupil responses can be robustly evoked using different stimulus contingencies (low-level acoustic changes, or higher level categorical changes); and that pupil responses are modulated by short-term training. These results lay the foundation for using pupillometry as a reliable method of estimating thresholds in large experimental cohorts, and unveil the full potential of using pupillometry to explore broad similarities between humans and animal models.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent2803334
dc.identifier.doi10.1038/s41598-021-82340-y
dc.identifier.issn2045-2322
dc.identifier.otherPURE: 28096365
dc.identifier.otherPURE UUID: 4037b050-3670-4bc9-9bb6-51c3d558d4c2
dc.identifier.otherScopus: 85100505995
dc.identifier.otherWOS: 000618049600066
dc.identifier.otherPubMed: 33542266
dc.identifier.urihttp://hdl.handle.net/10362/112275
dc.identifier.urlhttps://www.scopus.com/pages/publications/85100505995
dc.language.isoeng
dc.peerreviewedyes
dc.subjectGeneral
dc.titlePupillometry as a reliable metric of auditory detection and discrimination across diverse stimulus paradigms in animal modelsen
dc.typejournal article
degois.publication.issue1
degois.publication.titleScientific Reports
degois.publication.volume11
dspace.entity.typePublication
rcaap.rightsopenAccess

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