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Evaluation of the Polyphenolic Composition and Bioactivities of Three Native Cabo Verde Medicinal Plants

2022-09Artigo científico Acesso aberto
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dc.contributor.authorP. Essoh, Anyse
dc.contributor.authorLiberal, Ângela
dc.contributor.authorFernandes, Ângela
dc.contributor.authorDias, Maria Inês
dc.contributor.authorPereira, Carla
dc.contributor.authorMandim, Filipa
dc.contributor.authorMoldão-Martins, Margarida
dc.contributor.authorCravo, Pedro
dc.contributor.authorDuarte, Maria Paula
dc.contributor.authorMoura, Mónica
dc.contributor.authorRomeiras, Maria M.
dc.contributor.authorBarros, Lillian
dc.contributor.institutionVector borne diseases and pathogens (VBD)
dc.contributor.institutionGlobal Health and Tropical Medicine (GHTM)
dc.contributor.institutionInstituto de Higiene e Medicina Tropical (IHMT)
dc.contributor.institutionUniversidade NOVA de Lisboa
dc.contributor.institutionMEtRICS - Centro de Engenharia Mecânica e Sustentabilidade de Recursos
dc.contributor.institutionFaculdade de Ciências e Tecnologia (FCT)
dc.contributor.pblMolecular Diversity Preservation International (MDPI)
dc.date.accessioned2023-02-02T22:20:21Z
dc.date.available2023-02-02T22:20:21Z
dc.date.issued2022-09
dc.descriptionFunding Information: The authors are grateful to the Foundation for Science and Technology (FCT, Portugal) for financial support through national funds FCT/MCTES (PIDDAC) to CIMO (UIDB/00690/2020 and UIDP/00690/2020) and SusTEC (LA/P/0007/2021); National funding by FCT, P.I., through the individual scientific employment program contract for L. Barros, A. Fernandes, M.I. Dias and C. Pereira. This research was funded by Fundação para a Ciência e a Tecnologia (FCT) and Aga Khan Development Network (AKDN) under the project CVAgrobiodiversity/333111699. Publisher Copyright: © 2022 by the authors.
dc.description.abstractThe use of medicinal plants in a variety of health conditions remains essential for the discovery of new treatments. The present study aimed to investigate the bioactive properties of three native plants from Cabo Verde Islands, namely Artemisia gorgonum Webb, Sideroxylon marginatum (Decne. ex Webb) Cout., and Tamarix senegalensis DC., contributing to the characterization of less-known medicinal plants and their potential benefits for human health. Known compounds, such as kaempferol, quercetin, caffeyolquinic, and apigenin derivatives, among others, were detected in the plant species under study. Overall, all species demonstrated good antioxidant capacity, especially the ethanolic extracts of A. gorgonum (EC50 = 0.149 mg/mL) in TBARS assay. Moreover, the ethanolic extracts of the studied plants showed cytotoxic properties against tumor cells, and again the A. gorgonum extract proved to be the most effective in inhibiting tumor growth, mainly in the CaCO2 (GI50 = 17.3 μg/mL) and AGS (GI50 = 18.2 μg/mL) cell lines. Only the ethanolic extracts of T. senegalensis and S. marginatum demonstrated anti-inflammatory activity, albeit weak (EC50 = 35 and 43 μg/mL, respectively). The present study contributed to increased knowledge about the bioactive properties of these plants commonly used in traditional medicine, some of which was discussed for the first time, opening new perspectives for their use in a wider range of health conditions, especially in African countries, where access to modern health care is more limited.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent344955
dc.identifier.doi10.3390/ph15091162
dc.identifier.issn1424-8247
dc.identifier.otherPURE: 50798936
dc.identifier.otherPURE UUID: 95f88123-72b1-471c-81f3-e93c3f4eca98
dc.identifier.otherScopus: 85139560945
dc.identifier.otherPubMed: 36145383
dc.identifier.otherWOS: 000858764100001
dc.identifier.otherORCID: /0000-0003-1675-4504/work/126766794
dc.identifier.urihttp://hdl.handle.net/10362/148589
dc.identifier.urlhttps://www.scopus.com/pages/publications/85139560945
dc.language.isoeng
dc.peerreviewedyes
dc.subjectbioactive properties
dc.subjectCabo Verde
dc.subjectendemic medicinal plants
dc.subjecttraditional medicine
dc.subjectRM Therapeutics. Pharmacology
dc.subjectRS Pharmacy and materia medica
dc.subjectRV Botanic, Thomsonian, and eclectic medicine
dc.subjectMolecular Medicine
dc.subjectPharmaceutical Science
dc.subjectDrug Discovery
dc.subjectSDG 3 - Good Health and Well-being
dc.subjectSDG 12 - Responsible Consumption and Production
dc.titleEvaluation of the Polyphenolic Composition and Bioactivities of Three Native Cabo Verde Medicinal Plantsen
dc.typejournal article
degois.publication.issue9
degois.publication.titlePharmaceuticals
degois.publication.volume15
dspace.entity.typePublication
rcaap.rightsopenAccess

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