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Attrition, physical integrity and insecticidal activity of long-lasting insecticidal nets in sub-Saharan Africa and modelling of their impact on vectorial capacity

2020-08-28Artigo científico Acesso aberto
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dc.contributor.authorBriet, Olivier
dc.contributor.authorKoenker, Hannah
dc.contributor.authorNorris, Laura
dc.contributor.authorWiegand, Ryan
dc.contributor.authorVanden Eng, Jodi
dc.contributor.authorThackeray, Alex
dc.contributor.authorWilliamson, John
dc.contributor.authorGimnig, John E.
dc.contributor.authorFortes, Filomeno
dc.contributor.authorAkogbeto, Martin
dc.contributor.authorYadouleton, Anges W.
dc.contributor.authorOmbok, Maurice
dc.contributor.authorBayoh, M. Nabie
dc.contributor.authorMzilahowa, Themba
dc.contributor.authorAbílio, Ana Paula
dc.contributor.authorMabunda, Samuel
dc.contributor.authorCuamba, Nelson
dc.contributor.authorDiouf, Elhadji
dc.contributor.authorKonaté, Lassana
dc.contributor.authorHamainza, Busiku
dc.contributor.authorKatebe-Sakala, Cecilia
dc.contributor.authorPonce De León, Gabriel
dc.contributor.authorAsamoa, Kwame
dc.contributor.authorWolkon, Adam
dc.contributor.authorSmith, Stephen C.
dc.contributor.authorSwamidoss, Isabel
dc.contributor.authorGreen, Mike
dc.contributor.authorGueye, Salam
dc.contributor.authorMihigo, Jules
dc.contributor.authorMorgan, Juliette
dc.contributor.authorDotson, Ellen
dc.contributor.authorCraig, Allen S.
dc.contributor.authorTan, Kathrine R.
dc.contributor.authorWirtz, Robert A.
dc.contributor.authorSmith, Tom
dc.contributor.institutionIndividual Health Care (IHC)
dc.contributor.institutionGlobal Health and Tropical Medicine (GHTM)
dc.contributor.institutionInstituto de Higiene e Medicina Tropical (IHMT)
dc.contributor.pblBioMed Central (BMC)
dc.date.accessioned2025-03-17T21:08:05Z
dc.date.available2025-03-17T21:08:05Z
dc.date.issued2020-08-28
dc.descriptionFunding information: This study was made possible by the generous support of the American people through the United States Agency for International Development (USAID) under the terms of USAID/JHU Cooperative Agreement No: AID-OAA-A-14-00057 for the VectorWorks Project. Additional funding for Tom Smith was provided by the Bill & Melinda Gates Foundation project OPP1032350.
dc.description.abstractBackground: Long-lasting insecticidal nets (LLINs) are the primary malaria prevention and control intervention in many parts of sub-Saharan Africa. While LLINs are expected to last at least 3 years under normal use conditions, they can lose effectiveness because they fall out of use, are discarded, repurposed, physically damaged, or lose insecticidal activity. The contributions of these different interrelated factors to durability of nets and their protection against malaria have been unclear. Methods: Starting in 2009, LLIN durability studies were conducted in seven countries in Africa over 5 years. WHO-recommended measures of attrition, LLIN use, insecticidal activity, and physical integrity were recorded for eight different net brands. These data were combined with analyses of experimental hut data on feeding inhibition and killing effects of LLINs on both susceptible and pyrethroid resistant malaria vectors to estimate the protection against malaria transmission - in terms of vectorial capacity (VC) - provided by each net cohort over time. Impact on VC was then compared in hypothetical scenarios where one durability outcome measure was set at the best possible level while keeping the others at the observed levels. Results: There was more variability in decay of protection over time by country than by net brand for three measures of durability (ratios of variance components 4.6, 4.4, and 1.8 times for LLIN survival, use, and integrity, respectively). In some countries, LLIN attrition was slow, but use declined rapidly. Non-use of LLINs generally had more effect on LLIN impact on VC than did attrition, hole formation, or insecticide loss. Conclusions: There is much more variation in LLIN durability among countries than among net brands. Low levels of use may have a larger impact on effectiveness than does variation in attrition or LLIN degradation. The estimated entomological effects of chemical decay are relatively small, with physical decay probably more important as a driver of attrition and non-use than as a direct cause of loss of effect. Efforts to maximize LLIN impact in operational settings should focus on increasing LLIN usage, including through improvements in LLIN physical integrity. Further research is needed to understand household decisions related to LLIN use, including the influence of net durability and the presence of other nets in the household.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent15
dc.format.extent3363364
dc.identifier.doi10.1186/s12936-020-03383-6
dc.identifier.issn1475-2875
dc.identifier.otherPURE: 26669000
dc.identifier.otherPURE UUID: 8a970979-a5b0-4b01-af20-a0887ea3a8ce
dc.identifier.otherScopus: 85090169569
dc.identifier.otherWOS: 000566955200002
dc.identifier.otherPubMed: 32859210
dc.identifier.otherPubMedCentral: PMC7456088
dc.identifier.urihttp://hdl.handle.net/10362/180747
dc.identifier.urlhttps://www.scopus.com/pages/publications/85090169569
dc.language.isoeng
dc.peerreviewedyes
dc.subjectDurability monitoring
dc.subjectLong-lasting insecticidal nets
dc.subjectMalaria
dc.subjectVectorial capacity
dc.subjectParasitology
dc.subjectInfectious Diseases
dc.subjectSDG 3 - Good Health and Well-being
dc.titleAttrition, physical integrity and insecticidal activity of long-lasting insecticidal nets in sub-Saharan Africa and modelling of their impact on vectorial capacityen
dc.typejournal article
degois.publication.firstPage310
degois.publication.issue1
degois.publication.lastPage325
degois.publication.titleMalaria Journal
degois.publication.volume19
dspace.entity.typePublication
rcaap.rightsopenAccess

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