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Antibiotic susceptibility pattern of Portuguese environmental Legionella isolates

2023-04-21Artigo científico Acesso aberto
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dc.contributor.authorCruz, Carolina
dc.contributor.authorRodrigues, Lúcia
dc.contributor.authorFernandes, Filipa
dc.contributor.authorSantos, Ricardo
dc.contributor.authorPaixão, Paulo
dc.contributor.authorPaixão, Paulo
dc.contributor.authorChasqueira, Maria Jesus
dc.contributor.authorChasqueira, Maria-Jesus
dc.contributor.institutionNOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
dc.contributor.institutionComprehensive Health Research Centre (CHRC) - pólo NMS
dc.contributor.pblFrontiers Media
dc.date.accessioned2023-05-22T22:18:29Z
dc.date.available2023-05-22T22:18:29Z
dc.date.issued2023-04-21
dc.descriptionPublisher Copyright: Copyright © 2023 Cruz, Rodrigues, Fernandes, Santos, Paixão and Chasqueira.
dc.description.abstractIntroduction: Legionnaires’ Disease is a pneumonia caused by Legionella spp., currently treated empirically with fluoroquinolones and macrolides. In this study, we aim to describe the antibiotic susceptibility pattern of environmental Legionella recovered in the south of Portugal. Methods: Minimal inhibitory concentration (MIC) determination of 57 Legionella isolates (10 Lp sg 1, 32, Lp sg 2-14 15 L. spp) was achieved by broth microdilution, as described by EUCAST, for azithromycin, clarithromycin, ciprofloxacin, levofloxacin, and doxycycline. Results: Fluoroquinolones were the most active antibiotic, displaying the lowest MIC values in contrast to doxycycline which had the highest. MIC90 and epidemiological cut-off (ECOFF) values were, respectively, 0.5/1 mg/L for azithromycin, 0.125/0.25 mg/L for clarithromycin, 0.064/0.125 mg/L for ciprofloxacin, 0.125/0.125 mg/L for levofloxacin and 16/32 mg/L for doxycycline. Discussion: MIC distributions were higher than reported by EUCAST for all antibiotics. Interestingly, two phenotypically resistant isolates with high-level quinolone resistance were identified. This is the first time that MIC distributions, lpeAB and tet56 genes have been investigated in Portuguese environmental isolates of Legionella.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent545109
dc.identifier.doi10.3389/fcimb.2023.1141115
dc.identifier.issn2235-2988
dc.identifier.otherPURE: 60958533
dc.identifier.otherPURE UUID: 84ae419e-8187-43ad-bbbe-8b415e52155c
dc.identifier.otherScopus: 85158028688
dc.identifier.otherPubMed: 37153155
dc.identifier.urihttp://hdl.handle.net/10362/153054
dc.identifier.urlhttps://www.scopus.com/pages/publications/85158028688
dc.language.isoeng
dc.peerreviewedyes
dc.subjectantibiotic susceptibility
dc.subjectbroth microdilution
dc.subjectenvironmental
dc.subjectfluoroquinolones
dc.subjectLegionella
dc.subjectmacrolides
dc.subjectMIC
dc.subjectMicrobiology
dc.subjectImmunology
dc.subjectMicrobiology (medical)
dc.subjectInfectious Diseases
dc.subjectSDG 3 - Good Health and Well-being
dc.titleAntibiotic susceptibility pattern of Portuguese environmental Legionella isolatesen
dc.typejournal article
degois.publication.titleFrontiers in Cellular and Infection Microbiology
degois.publication.volume13
dspace.entity.typePublication
person.familyNamePaixão
person.familyNameChasqueira
person.givenNamePaulo
person.givenNameMaria-Jesus
person.identifier.orcid0000-0002-4294-0872
person.identifier.orcid0000-0002-8015-7109
person.identifier.scopus-author-id6508103792
rcaap.rightsopenAccess
relation.isAuthorOfPublication05b765bd-f025-43ee-8cf5-2e54ceb007cb
relation.isAuthorOfPublication072ec2a7-7dea-429d-bdb3-2d9fa3f1e79d
relation.isAuthorOfPublication.latestForDiscovery072ec2a7-7dea-429d-bdb3-2d9fa3f1e79d

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