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Enhancing the magnetic properties of superparamagnetic iron oxide nanoparticles using hydrothermal treatment for magnetic hyperthermia application

2025-02-10Artigo científico Acesso aberto
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dc.contributor.authorMartins, Carla
dc.contributor.authorRolo, Catarina
dc.contributor.authorCacho, Vanessa R. G.
dc.contributor.authorPereira, Laura C. J.
dc.contributor.authorBorges, João Paulo
dc.contributor.authorSilva, Jorge Carvalho
dc.contributor.authorVieira, Tânia
dc.contributor.authorSoares, Paula I. P.
dc.contributor.institutionCENIMAT-i3N - Centro de Investigação de Materiais (Lab. Associado I3N)
dc.contributor.institutionDCM - Departamento de Ciência dos Materiais
dc.contributor.institutionDF – Departamento de Física
dc.contributor.pblRSC - Royal Society of Chemistry
dc.date.accessioned2025-07-04T21:17:37Z
dc.date.available2025-07-04T21:17:37Z
dc.date.issued2025-02-10
dc.descriptionFunding Information: The authors acknowledge the support of FCT-Fundação para a Ciência e a Tecnologia, I. P., in the scope of project PTDC/BTM-MAT/2472/2021 and the projects LA/P/0037/2020, UIDP/50025/2020, and UIDB/50025/2020 of the Associate Laboratory Institute of Nanostructures, Nanomodelling and Nanofabrication-i3N, and projects UID/Multi/04349/2019 and LISBOA-01-0145-FEDER-022096 of Center of Sciences and Nuclear Technologies, C2TN. P. S. also acknowledges the individual contract CEECIND.03189.2020. Carla Martins and Catarina Rolo contributed equally to this work. Publisher Copyright: © 2025 RSC.
dc.description.abstractSuperparamagnetic iron oxide nanoparticles (SPIONs) are the most commonly used inorganic nanoparticles for magnetic hyperthermia in cancer treatment. In this technique, the temperature of the tumor is increased by applying an external alternating magnetic field, which induces heat release from magnetic nanoparticles located at the tumor site. In this study, SPIONs were produced using the chemical co-precipitation technique combined with hydrothermal treatment to reduce their size dispersibility and increase their crystallinity, which are directly related to their magnetic properties. The size of the SPIONs increased from 9 nm to 20 nm after hydrothermal treatment at 160 °C for 24 h. These NPs exhibit a cubic/rectangular shape with a structure composed of both magnetite and maghemite. Their superparamagnetic behavior was confirmed, and the magnetic saturation increased from 58 to 73 emu g−1 at RT and from 67 to 81 emu g−1 at 10 K. Magnetic hyperthermia measurements showed an increase in SAR values from 83 to about 160-200 W g−1, depending on the hydrothermal treatment conditions. Additionally, the exposure of normal and melanoma cells to SPIONs in the presence of an alternating magnetic field leads to a significant reduction in cell viability, with a more pronounced effect in melanoma cells. These results demonstrate the high potential of this synthesis technique for producing SPIONs for cancer treatment via magnetic hyperthermia.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent18
dc.format.extent5282316
dc.identifier.doi10.1039/d4ma01120a
dc.identifier.issn2633-5409
dc.identifier.otherPURE: 118407752
dc.identifier.otherPURE UUID: 28f810cf-36d4-4c49-9f79-c242c90aef3f
dc.identifier.otherScopus: 86000373297
dc.identifier.otherWOS: 001416538100001
dc.identifier.otherORCID: /0000-0001-9959-4272/work/187323240
dc.identifier.otherORCID: /0000-0002-3996-6545/work/187323675
dc.identifier.otherORCID: /0000-0001-8447-1886/work/187323734
dc.identifier.urihttp://hdl.handle.net/10362/184837
dc.identifier.urlhttps://www.scopus.com/pages/publications/86000373297
dc.identifier.urlhttps://www.webofscience.com/wos/woscc/full-record/WOS:001416538100001
dc.language.isoeng
dc.peerreviewedyes
dc.relationinfo:eu-repo/grantAgreement/FCT/Concurso de Projetos IC&DT em Todos os Domínios Científicos/PTDC%2FBTM-MAT%2F2472%2F2021/PT
dc.relationTowards the development of a nanoparticle for early diagnosis of Alzheimer’s Disease, based on the reversible translocation of the blood brain barrier.
dc.relationInstitute of Nanostructures, Nanomodelling and Nanofabrication
dc.relationInstitute of Nanostructures, Nanomodelling and Nanofabrication
dc.relationCentre for Nuclear Sciences and Technologies
dc.relationinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FMulti%2F04349%2F2019/PT
dc.subjectChemistry (miscellaneous)
dc.subjectGeneral Materials Science
dc.subjectSDG 3 - Good Health and Well-being
dc.titleEnhancing the magnetic properties of superparamagnetic iron oxide nanoparticles using hydrothermal treatment for magnetic hyperthermia applicationen
dc.typejournal article
degois.publication.firstPage1726
degois.publication.issue5
degois.publication.lastPage1743
degois.publication.titleMaterials Advances
degois.publication.volume6
dspace.entity.typePublication
oaire.awardNumberPTDC/BTM-MAT/2472/2021
oaire.awardNumberLA/P/0037/2020
oaire.awardNumberUIDP/50025/2020
oaire.awardNumberUIDB/50025/2020
oaire.awardNumberUID/Multi/04349/2019
oaire.awardTitleTowards the development of a nanoparticle for early diagnosis of Alzheimer’s Disease, based on the reversible translocation of the blood brain barrier.
oaire.awardTitleInstitute of Nanostructures, Nanomodelling and Nanofabrication
oaire.awardTitleInstitute of Nanostructures, Nanomodelling and Nanofabrication
oaire.awardTitleCentre for Nuclear Sciences and Technologies
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/Concurso de Projetos IC&DT em Todos os Domínios Científicos/PTDC%2FBTM-MAT%2F2472%2F2021/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/LA%2FP%2F0037%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F50025%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/Concurso de avaliação no âmbito do Programa Plurianual de Financiamento de Unidades de I&D (2017%2F2018) - Financiamento Base/UIDB%2F50025%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FMulti%2F04349%2F2019/PT
oaire.fundingStreamConcurso de Projetos IC&DT em Todos os Domínios Científicos
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamConcurso de avaliação no âmbito do Programa Plurianual de Financiamento de Unidades de I&D (2017/2018) - Financiamento Base
oaire.fundingStream6817 - DCRRNI ID
project.funder.identifierhttp://doi.org/10.13039/501100001871
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project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
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project.funder.nameFundação para a Ciência e a Tecnologia
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