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Validation of Serum Calprotectin Relative to Other Biomarkers of Infection in Febrile Infants Presenting to the Emergency Department

2024-05Artigo científico Acesso aberto
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dc.contributor.authorBohn, Mary Kathryn
dc.contributor.authorHavelka, Aleksandra
dc.contributor.authorEriksson, Mats
dc.contributor.authorAdeli, Khosrow
dc.contributor.institutionNOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
dc.contributor.pblMDPI - Multidisciplinary Digital Publishing Institute
dc.date.accessioned2024-06-18T01:29:53Z
dc.date.available2024-06-18T01:29:53Z
dc.date.issued2024-05
dc.descriptionFunding Information: This research was funded by a Foundation Grant from the Canadian Institutes for Health Research, as well as reagent/grant support from Gentian Diagnostics. The funding bodies had no role in the design of the study, data collection, interpretation, or in the writing of the manuscript. Publisher Copyright: © 2024 by the authors.
dc.description.abstractAntimicrobial stewardship involves a delicate balance between the risk of undertreating individuals and the potential societal burden of overprescribing antimicrobials. This balance is especially crucial in neonatal care. In this observational study, the usefulness of biomarkers of infectious diseases (calprotectin, procalcitonin (PCT), C-reactive protein (CRP), and white blood cells (WBCs) were evaluated in 141 febrile infants aged 28–90 days presenting to an emergency department. Since our focus was on the usefulness of serum calprotectin, this biomarker was not part of clinical decision-making. A significant difference was observed in the levels of all biomarkers, related to final discharge diagnosis and disposition status. The difference in levels related to antibiotic prescription was significant for all biomarkers but WBCs. The performance of calprotectin in the detection of bacterial infections (AUC (95% CI): 0.804 (0.691, 0.916)) was comparable to the performance of both PCT (0.901 (0.823, 0.980)) and CRP (0.859 (0.764, 0.953)) and superior to the WBC count (0.684 (0.544, 0.823)). Procalcitonin and CRP demonstrated a statistically significantly higher specificity relative to calprotectin. In this cohort, antibiotic use did not always correlate to a definite diagnosis of confirmed bacterial infection. The sample size was limited due to associated challenges with recruiting febrile infants. Hence, there is a need for adequate diagnostic tools to help discriminate between various kinds of infections. This study suggests serum calprotectin, procalcitonin, and CRP may serve as valuable biomarkers to differentiate between types of infection, in addition to clinical input and decision-making.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent2549285
dc.identifier.doi10.3390/antibiotics13050425
dc.identifier.issn2079-6382
dc.identifier.otherPURE: 92754788
dc.identifier.otherPURE UUID: 2ba19462-ffe7-466c-a233-fd680772dfe1
dc.identifier.otherScopus: 85194184311
dc.identifier.urihttp://hdl.handle.net/10362/168695
dc.identifier.urlhttps://www.scopus.com/pages/publications/85194184311
dc.language.isoeng
dc.peerreviewedyes
dc.subjectantibiotic
dc.subjectbiomarker
dc.subjectcalprotectin
dc.subjectemergency department
dc.subjectinfection
dc.subjectneonate
dc.subjectMicrobiology
dc.subjectBiochemistry
dc.subjectPharmacology, Toxicology and Pharmaceutics(all)
dc.subjectMicrobiology (medical)
dc.subjectInfectious Diseases
dc.subjectPharmacology (medical)
dc.subjectSDG 3 - Good Health and Well-being
dc.titleValidation of Serum Calprotectin Relative to Other Biomarkers of Infection in Febrile Infants Presenting to the Emergency Departmenten
dc.typejournal article
degois.publication.issue5
degois.publication.titleAntibiotics
degois.publication.volume13
dspace.entity.typePublication
rcaap.rightsopenAccess

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