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Functionalisation of Electrospun Cellulose Acetate Membranes with PEDOT and PPy for Electronic Controlled Drug Release

2023-04-27Artigo científico Acesso aberto
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dc.contributor.authorLago, Beatriz
dc.contributor.authorBrito, Miguel
dc.contributor.authorAlmeida, Cristina M. M.
dc.contributor.authorFerreira, Isabel
dc.contributor.authorBaptista, Ana Catarina
dc.contributor.institutionDCM - Departamento de Ciência dos Materiais
dc.contributor.institutionCENIMAT-i3N - Centro de Investigação de Materiais (Lab. Associado I3N)
dc.contributor.pblMDPI AG
dc.date.accessioned2023-07-06T22:17:32Z
dc.date.available2023-07-06T22:17:32Z
dc.date.issued2023-04-27
dc.descriptionFunding Information: This work was also supported by ERC-CoG-2014, CapTherPV, 647596. Publisher Copyright: © 2023 by the authors.
dc.description.abstractControlled drug release via electrical stimulation from drug-impregnated fibres was studied using electrospun cellulose acetate (CA) membranes and encapsulated ibuprofen (IBU). This research outlines the influence of polypyrrole (PPy) and poly(3,4-ethylenedioxythiophene) (PEDOT)-functionalised CA membranes and their suitability for dermal electronic-controlled drug release. Micro Raman analysis confirmed polymer functionalisation of CA membranes and drug incorporation. Scanning electron microscopy (SEM) images evidenced the presence of PPy and PEDOT coatings. The kinetic of drug release was analysed, and the passive and active release was compared. In the proposed systems, the drug release is controlled by very low electrical potentials. A potential of −0.3 V applied to membranes showed the ibuprofen retention, and a positive potential of +0.3 V, +0.5 V, or +0.8 V, depending on the conductive polymer and membrane configuration, enhanced the drug release. A small adhesive patch was constructed to validate this system for cutaneous application and verified an “ON/OFF” ibuprofen release pattern from membranes.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent18
dc.format.extent3824211
dc.identifier.doi10.3390/nano13091493
dc.identifier.issn2079-4991
dc.identifier.otherPURE: 65374145
dc.identifier.otherPURE UUID: 07b80720-edf9-49b7-8c72-3f1ecfff5acd
dc.identifier.otherScopus: 85159174355
dc.identifier.otherWOS: 000987330800001
dc.identifier.otherPubMed: 37177038
dc.identifier.otherPubMedCentral: PMC10180495
dc.identifier.otherORCID: /0000-0002-8838-0364/work/151368134
dc.identifier.otherORCID: /0000-0003-1631-6248/work/151427093
dc.identifier.urihttp://hdl.handle.net/10362/154939
dc.identifier.urlhttps://www.scopus.com/pages/publications/85159174355
dc.language.isoeng
dc.peerreviewedyes
dc.relationinfo:eu-repo/grantAgreement/FCT/Concurso para Financiamento de Projetos de Investigação Científica e Desenvolvimento Tecnológico em Todos os Domínios Científicos - 2020/PTDC%2FCTM-CTM%2F1571%2F2020/PT
dc.relationinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/LA%2FP%2F0037%2F2020/PT
dc.relationInstitute of Nanostructures, Nanomodelling and Nanofabrication
dc.relationInstitute of Nanostructures, Nanomodelling and Nanofabrication
dc.relationInstitute of Nanostructures, Nanomodelling and Nanofabrication
dc.subjectcellulose acetate
dc.subjectconducting polymers
dc.subjectcontrolled drug release system
dc.subjectelectrical stimuli
dc.subjectelectrospinning
dc.subjectPEDOT
dc.subjectpolypyrrole
dc.subjectGeneral Chemical Engineering
dc.subjectGeneral Materials Science
dc.titleFunctionalisation of Electrospun Cellulose Acetate Membranes with PEDOT and PPy for Electronic Controlled Drug Releaseen
dc.typejournal article
degois.publication.issue9
degois.publication.titleNanomaterials
degois.publication.volume13
dspace.entity.typePublication
oaire.awardNumberPTDC/CTM-CTM/1571/2020
oaire.awardNumberLA/P/0037/2020
oaire.awardNumberUIDP/50025/2020
oaire.awardNumberUIDB/50025/2020
oaire.awardTitleInstitute of Nanostructures, Nanomodelling and Nanofabrication
oaire.awardTitleInstitute of Nanostructures, Nanomodelling and Nanofabrication
oaire.awardTitleInstitute of Nanostructures, Nanomodelling and Nanofabrication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/Concurso para Financiamento de Projetos de Investigação Científica e Desenvolvimento Tecnológico em Todos os Domínios Científicos - 2020/PTDC%2FCTM-CTM%2F1571%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/LA%2FP%2F0037%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F50025%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F50025%2F2020/PT
oaire.fundingStreamConcurso para Financiamento de Projetos de Investigação Científica e Desenvolvimento Tecnológico em Todos os Domínios Científicos - 2020
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
project.funder.identifierhttp://doi.org/10.13039/501100001871
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project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccess
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