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Childhood generalized specific phobia as an early marker of internalizing psychopathology across the lifespan

2019-05-24Artigo científico Acesso aberto
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dc.contributor.authorDe Vries, Ymkje Anna
dc.contributor.authorAl-Hamzawi, Ali
dc.contributor.authorAlonso, Jordi
dc.contributor.authorBorges, Guilherme
dc.contributor.authorBruffaerts, Ronny
dc.contributor.authorBunting, Brendan
dc.contributor.authorCaldas-De-Almeida, José Miguel
dc.contributor.authorJM, Caldas-de-Almeida
dc.contributor.authorCia, Alfredo H.
dc.contributor.authorDe Girolamo, Giovanni
dc.contributor.authorDinolova, Rumyana V.
dc.contributor.authorEsan, Oluyomi
dc.contributor.authorFlorescu, Silvia
dc.contributor.authorGureje, Oye
dc.contributor.authorHaro, Josep Maria
dc.contributor.authorHu, Chiyi
dc.contributor.authorKaram, Elie G.
dc.contributor.authorKaram, Aimee Nasser
dc.contributor.authorKawakami, Norito
dc.contributor.authorKiejna, Andrzej
dc.contributor.authorKovess-Masfety, Viviane
dc.contributor.authorLee, Sing
dc.contributor.authorMneimneh, Zeina
dc.contributor.authorNavarro-Mateu, Fernando
dc.contributor.authorPiazza, Marina
dc.contributor.authorScott, Kate M.
dc.contributor.authorTen Have, Margreet
dc.contributor.authorTorres, Yolanda
dc.contributor.authorViana, Maria Carmen
dc.contributor.authorKessler, Ronald C.
dc.contributor.authorKessler, Ronald
dc.contributor.authorDe Jonge, Peter
dc.contributor.authorAguilar-Gaxiola, Sergio
dc.contributor.authorAl-Kaisy, Mohammed Salih
dc.contributor.authorAndrade, Laura Helena
dc.contributor.authorBenjet, Corina
dc.contributor.authorBromet, Evelyn J.
dc.contributor.authorDe Almeida, Jose Miguel Caldas
dc.contributor.authorCardoso, Graça
dc.contributor.authorCardoso, Graca
dc.contributor.authorChatterji, Somnath
dc.contributor.authorDegenhardt, Louisa
dc.contributor.authorDemyttenaere, Koen
dc.contributor.authorHinkov, Hristo
dc.contributor.authorHu, Chi Yi
dc.contributor.authorKaram, Aimee Nasser
dc.contributor.authorLepine, Jean Pierre
dc.contributor.authorLevinson, Daphna
dc.contributor.authorMcGrath, John
dc.contributor.authorMedina-Mora, Maria Elena
dc.contributor.authorMoskalewicz, Jacek
dc.contributor.authorPennell, Beth Ellen
dc.contributor.authorPosada-Villa, Jose
dc.contributor.authorScott, Kate M.
dc.contributor.authorSlade, Tim
dc.contributor.authorStagnaro, Juan Carlos
dc.contributor.authorStein, Dan J.
dc.contributor.authorWhiteford, Harvey
dc.contributor.authorWilliams, David R.
dc.contributor.authorWojtyniak, Bogdan
dc.contributor.institutionNOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
dc.contributor.pblBioMed Central (BMC)
dc.date.accessioned2019-07-18T22:51:25Z
dc.date.available2019-07-18T22:51:25Z
dc.date.issued2019-05-24
dc.description.abstractBackground: Specific phobia (SP) is a relatively common disorder associated with high levels of psychiatric comorbidity. Because of its early onset, SP may be a useful early marker of internalizing psychopathology, especially if generalized to multiple situations. This study aimed to evaluate the association of childhood generalized SP with comorbid internalizing disorders. Methods: We conducted retrospective analyses of the cross-sectional population-based World Mental Health Surveys using the Composite International Diagnostic Interview. Outcomes were lifetime prevalence, age of onset, and persistence of internalizing disorders; past-month disability; lifetime suicidality; and 12-month serious mental illness. Logistic and linear regressions were used to assess the association of these outcomes with the number of subtypes of childhood-onset (< 13 years) SP. Results: Among 123,628 respondents from 25 countries, retrospectively reported prevalence of childhood SP was 5.9%, 56% of whom reported one, 25% two, 10% three, and 8% four or more subtypes. Lifetime prevalence of internalizing disorders increased from 18.2% among those without childhood SP to 46.3% among those with one and 75.6% those with 4+ subtypes (OR = 2.4, 95% CI 2.3-2.5, p < 0.001). Twelve-month persistence of lifetime internalizing comorbidity at interview increased from 47.9% among those without childhood SP to 59.0% and 79.1% among those with 1 and 4+ subtypes (OR = 1.4, 95% CI 1.4-1.5, p < 0.001). Respondents with 4+ subtypes also reported significantly more disability (3.5 days out of role in the past month) than those without childhood SP (1.1 days) or with only 1 subtype (1.8 days) (B = 0.56, SE 0.06, p < 0.001) and a much higher rate of lifetime suicide attempts (16.8%) than those without childhood SP (2.0%) or with only 1 subtype (6.5%) (OR = 1.7, 95% CI 1.7-1.8, p < 0.001). Conclusions: This large international study shows that childhood-onset generalized SP is related to adverse outcomes in the internalizing domain throughout the life course. Comorbidity, persistence, and severity of internalizing disorders all increased with the number of childhood SP subtypes. Although our study cannot establish whether SP is causally associated with these poor outcomes or whether other factors, such as a shared underlying vulnerability, explain the association, our findings clearly show that childhood generalized SP identifies an important target group for early intervention.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent724297
dc.identifier.doi10.1186/s12916-019-1328-3
dc.identifier.otherPURE: 13814981
dc.identifier.otherPURE UUID: f037b89e-8e3f-40be-a171-4f1fac308ece
dc.identifier.otherScopus: 85066396682
dc.identifier.otherPubMed: 31122269
dc.identifier.otherWOS: 000468897600001
dc.identifier.urihttp://www.scopus.com/inward/record.url?scp=85066396682&partnerID=8YFLogxK
dc.identifier.urlhttps://www.scopus.com/pages/publications/85066396682
dc.language.isoeng
dc.peerreviewedyes
dc.subjectComorbidity
dc.subjectEarly markers
dc.subjectInternalizing disorders
dc.subjectSpecific phobia
dc.subjectSuicidality
dc.subjectGeneral Medicine
dc.subjectSDG 3 - Good Health and Well-being
dc.titleChildhood generalized specific phobia as an early marker of internalizing psychopathology across the lifespanen
dc.title.subtitleResults from the World Mental Health Surveysen
dc.typejournal article
degois.publication.issue1
degois.publication.titleBMC Medicine
degois.publication.volume17
dspace.entity.typePublication
person.familyNamecaldas de almeida
person.familyNameKessler
person.familyNameCardoso
person.givenNamejosé miguel
person.givenNameRonald
person.givenNameGraça
person.identifier.ciencia-idA217-C270-9BA2
person.identifier.ciencia-id9F16-E03A-E150
person.identifier.orcid0000-0003-1902-6772
person.identifier.orcid0000-0003-4831-2305
person.identifier.orcid0000-0003-1756-0197
person.identifier.scopus-author-id6506787166
person.identifier.scopus-author-id7005057979
rcaap.rightsopenAccess
relation.isAuthorOfPublicationb48afbbc-5703-4b0f-8c88-6beb5432d327
relation.isAuthorOfPublication6c1a1bfc-ebea-4ec9-9e0b-ee83533fa86f
relation.isAuthorOfPublication1dadf86e-5bf3-44d4-a3a3-894f3558dba8
relation.isAuthorOfPublication.latestForDiscoveryb48afbbc-5703-4b0f-8c88-6beb5432d327

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