Logo do repositório
 
Publicação

Impact of patient characteristics on ASDAS disease activity state cut-offs in axial spondyloarthritis

2024-11-02Artigo científico Acesso aberto
Ver registo simples
dc.contributor.authorØrnbjerg, Lykke M.
dc.contributor.authorGeorgiadis, Stylianos
dc.contributor.authorKvien, Tore K.
dc.contributor.authorMichelsen, Brigitte
dc.contributor.authorRasmussen, Simon
dc.contributor.authorPavelka, Karel
dc.contributor.authorZavada, Jakub
dc.contributor.authorLoft, Anne Gitte
dc.contributor.authorKenar, Gokce
dc.contributor.authorSolmaz, Dilek
dc.contributor.authorGlintborg, Bente
dc.contributor.authorRodrigues, Ana
dc.contributor.authorSantos, Maria Jose
dc.contributor.authorDi Guiseppe, Daniela
dc.contributor.authorWallman, Johan K.
dc.contributor.authorCiurea, Adrian
dc.contributor.authorNissen, Michael J.
dc.contributor.authorRotar, Ziga
dc.contributor.authorPirkmajer, Katja Perdan
dc.contributor.authorNordström, Dan
dc.contributor.authorHokkanen, Anna Mari
dc.contributor.authorGudbjornsson, Bjorn
dc.contributor.authorPalsson, Olafur
dc.contributor.authorHetland, Merete Lund
dc.contributor.authorØstergaard, Mikkel
dc.contributor.institutionNOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
dc.contributor.pblBMJ Publishing Group
dc.date.accessioned2024-11-15T23:33:00Z
dc.date.available2024-11-15T23:33:00Z
dc.date.issued2024-11-02
dc.descriptionPublisher Copyright: © Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
dc.description.abstractOBJECTIVES: To re-evaluate cut-offs for disease activity states according to the Axial Spondyloarthritis Disease Activity Score (ASDAS), and study the impact of sex, age, calendar time, disease and symptom duration on ASDAS and ASDAS cut-offs in a large contemporary cohort. METHODS: Data from 2939 patients with axial spondyloarthritis (axSpA) starting their first tumour necrosis factor inhibitor in nine European registries were pooled and analysed. Receiver operating characteristic analyses were performed to identify cut-offs against external criteria. Six-month data including patient and physician global assessments, both ≤1 (0-10 integer scale), and Assessment of SpondyloArthritis International Society partial remission were used for separation of inactive disease (ID) from low disease activity (LDA), while patient and physician global ≤3 were applied as external criteria to separate LDA from high disease activity (HDA). Patient and physician global ≥6 were applied to separate HDA from very high disease activity in baseline data. RESULTS: The three ASDAS cut-offs identified to separate the four disease activity states in the overall patient population were <1.3, <2.0 and >3.5. Cut-offs for ID and LDA in women were higher (<1.5 and <2.0, respectively) than in men (<1.3 and <1.9), as were cut-offs in patients ≥45 years (<1.5 and <2.2) versus ≤34 years (<1.2 and <1.9) and 35-44 years (<1.3 and <1.8). Cut-offs were independent of calendar time and disease duration. CONCLUSIONS: Re-evaluation of ASDAS cut-offs for disease activity states in a large multi-national axSpA cohort resulted in cut-offs similar to those currently endorsed. Differences in cut-offs between sex and age groups for ID and LDA were observed, but the differences were minor.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent623916
dc.identifier.doi10.1136/rmdopen-2024-004644
dc.identifier.issn2044-6055
dc.identifier.otherPURE: 103072022
dc.identifier.otherPURE UUID: ff28f898-b215-4dde-9714-befbe865d81d
dc.identifier.otherScopus: 85208475783
dc.identifier.otherPubMed: 39489531
dc.identifier.urihttp://hdl.handle.net/10362/175365
dc.identifier.urlhttps://www.scopus.com/pages/publications/85208475783
dc.language.isoeng
dc.peerreviewedyes
dc.subjectAxial Spondyloarthritis
dc.subjectDisease Activity
dc.subjectEpidemiology
dc.subjectRheumatology
dc.subjectImmunology and Allergy
dc.subjectImmunology
dc.titleImpact of patient characteristics on ASDAS disease activity state cut-offs in axial spondyloarthritisen
dc.title.subtitleresults from nine European rheumatology registriesen
dc.typejournal article
degois.publication.issue4
degois.publication.titleRMD Open
degois.publication.volume10
dspace.entity.typePublication
rcaap.rightsopenAccess

Ficheiros

Principais
A mostrar 1 - 1 de 1
Miniatura
Nome:
e004644.full.pdf
Tamanho:
609.29 KB
Formato:
Adobe Portable Document Format
Ver/Abrir

Coleções

NMS: CHRC - Artigos em revista internacional com arbitragem científica