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Diffusion tensor imaging and diffusion kurtosis imaging of the pancreas - feasibility, robustness and protocol comparison in a healthy population

2025-10Artigo científico Acesso aberto
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dc.contributor.authorBilreiro, Carlos
dc.contributor.authorAndrade, Luisa
dc.contributor.authorBilreiro, Carlos
dc.contributor.authorHenriques, Rafael
dc.contributor.authorLoução, Nuno
dc.contributor.authorMatos, Celso
dc.contributor.authorShemesh, Noam
dc.contributor.institutionNOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
dc.contributor.pblSpringer
dc.date.accessioned2025-04-24T21:11:17Z
dc.date.available2025-04-24T21:11:17Z
dc.date.issued2025-10
dc.descriptionPublisher Copyright: © The Author(s) 2025.
dc.description.abstractPurpose: This study aims to determine the feasibility, image quality, intra-subject repeatability and inter-reader variability of Diffusion tensor (DTI) and Diffusion kurtosis imaging (DKI) for pancreatic imaging using different protocols and report normative values in healthy individuals. Methods: Single-institution prospective study performed on healthy volunteers in a clinical 3T scanner, using two different protocols (6/16 diffusion directions). Acquisitions were repeated twice to assess intra-subject repeatability. To assess inter-reader variability, Mean diffusivity (MD), Axial diffusivity (AD), Radial diffusivity (RD), Apparent diffusion coefficient (ADC) and Mean kurtosis (MK) values were extracted from segmented pancreas by two radiologists. A Likert scale was used by both readers to assess subjective image quality. Results: Twelve healthy volunteers were recruited for each MRI protocol. The 6 diffusion directions protocol was shorter: 7 min vs. 14 min (corresponding to 4 min vs. 7.5 min for a DTI only reconstruction). No differences in image quality were found between protocols. Only MK maps showed implausible estimates, leading to the exclusion of median 16% and 17.7% pixels for the 6- and 16-direction protocols, respectively. Intra-subject repeatability was determined with negligible coefficients of repeatability for DTI; however, MK presented slightly higher values. Inter-reader agreement was excellent for all maps (ICC > 0.9). Conclusions: DTI and DKI of the pancreas are feasible in clinical settings, with excellent inter-observer agreement and good image quality. Intra-subject repeatability is excellent for DTI, but some variability was observed with DKI. A 6-directions protocol may be preferred due to faster acquisition without quantitatively compromising estimates. MK inaccuracies prompt further research for improving artifact correction.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent2296526
dc.identifier.doi10.1007/s00261-025-04889-w
dc.identifier.issn2366-004X
dc.identifier.otherPURE: 115327557
dc.identifier.otherPURE UUID: afff5099-353f-4edb-8e37-77dca2c0829d
dc.identifier.otherScopus: 105001481916
dc.identifier.urihttp://hdl.handle.net/10362/182600
dc.identifier.urlhttps://www.scopus.com/pages/publications/105001481916
dc.language.isoeng
dc.peerreviewedyes
dc.subjectAbdomen
dc.subjectDiffusion kurtosis imaging
dc.subjectDiffusion tensor imaging
dc.subjectFeasibility studies
dc.subjectHealthy volunteers
dc.subjectPancreas
dc.subjectRadiological and Ultrasound Technology
dc.subjectRadiology Nuclear Medicine and imaging
dc.subjectGastroenterology
dc.subjectUrology
dc.titleDiffusion tensor imaging and diffusion kurtosis imaging of the pancreas - feasibility, robustness and protocol comparison in a healthy populationen
dc.typejournal article
degois.publication.firstPage4563
degois.publication.issue10
degois.publication.lastPage4574
degois.publication.titleAbdominal Radiology
degois.publication.volume50
dspace.entity.typePublication
person.familyNameBilreiro
person.givenNameCarlos
person.identifier1767919
person.identifier.ciencia-id1A1D-0AF3-DFE9
person.identifier.orcid0000-0001-7755-0842
person.identifier.scopus-author-id56766208700
rcaap.rightsopenAccess
relation.isAuthorOfPublicationae4eb973-9d69-4f8a-a2f0-f89a3c8a04be
relation.isAuthorOfPublication.latestForDiscoveryae4eb973-9d69-4f8a-a2f0-f89a3c8a04be

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