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The Importance of Zebrafish in Biomedical Research

2013-09Artigo científico Acesso aberto
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dc.contributor.authorSantos, Ana Bárbara Tavares dos
dc.contributor.authorLopes, Susana Santos
dc.contributor.institutionCentro de Estudos de Doenças Crónicas (CEDOC)
dc.contributor.institutionNOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
dc.contributor.pblBiblioteca Nacional de Portugal, Centro de Estudos Históricos, CELOM
dc.date.accessioned2017-06-21T22:01:05Z
dc.date.available2017-06-21T22:01:05Z
dc.date.issued2013-09
dc.descriptionFUNDING SOURCE - PTDC/SAU-OBD/103981/2008 and SFRH/BPD/772587/2011
dc.description.abstractIntroduction: Zebrafish (Danio rerio) is an ideal model organism for the study of vertebrate development. This is due to the large clutches that each couple produces, with up to 200 embryos every 7 days, and to the fact that the embryos and larvae are small, transparent and undergo rapid external development. Material and Methods: Using scientific literature research tools available online and the keywords Zebrafish, biomedical research, human disease, and drug screening, we reviewed original studies and reviews indexed in PubMed. Results: In this review we summarized work conducted with this model for the advancement of our knowledge related to several human diseases. We also focused on the biomedical research being performed in Portugal with the zebrafish model. Discussion: Powerful live imaging and genetic tools are currently available for zebrafish making it a valuable model in biomedical research. The combination of these properties with the optimization of automated systems for drug screening has transformed the zebrafish into "a top model" in biomedical research, drug discovery and toxicity testing. Furthermore, with the optimization of xenografts technology it will be possible to use zebrafish to aide in the choice of the best therapy for each patient. Conclusion: Zebrafish is an excellent model organism in biomedical research, drug development and in clinical therapy.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent10
dc.format.extent545178
dc.identifier.issn1646-0758
dc.identifier.otherPURE: 297200
dc.identifier.otherPURE UUID: e00fac8e-b18b-45a0-b2cf-b3faa8e3b522
dc.identifier.otherresearchoutputwizard: 39964
dc.identifier.otherPubMed: 24192099
dc.identifier.otherWOS: 000327481500019
dc.identifier.otherScopus: 84887158160
dc.identifier.urihttp://hdl.handle.net/10362/21647
dc.language.isoeng
dc.peerreviewedyes
dc.relationinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/103981/PT
dc.subjectTUMOR ANGIOGENESIS
dc.subjectDisease Models, Animal
dc.subjectT-CELL LEUKEMIA
dc.subjectDANIO-RERIO
dc.subjectDrug Evaluation, Preclinical
dc.subjectDIFFERENT DEVELOPMENTAL-STAGES
dc.subjectMODEL ORGANISM
dc.subjectDRUG SCREENS
dc.subjectLIVER DEVELOPMENT
dc.subjectEXPOSURE ROUTES
dc.subjectBiomedical Research
dc.subjectZebrafish
dc.subjectIN-VIVO
dc.subjectTRANSGENIC ZEBRAFISH
dc.subjectSDG 3 - Good Health and Well-being
dc.titleThe Importance of Zebrafish in Biomedical Researchen
dc.typejournal article
degois.publication.firstPage583
degois.publication.issue5
degois.publication.lastPage592
degois.publication.titleActa Médica Portuguesa
degois.publication.volume26
dspace.entity.typePublication
oaire.awardNumberPTDC/SAU-OBD/103981/2008
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FSAU-OBD%2F103981%2F2008/PT
oaire.fundingStream3599-PPCDT
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccess
relation.isProjectOfPublication795220c5-819b-4773-a8ca-f4fcd6305925
relation.isProjectOfPublication.latestForDiscovery795220c5-819b-4773-a8ca-f4fcd6305925

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