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Reduction of mosquito survival in mice vaccinated with Anopheles stephensi glucose transporter

2017Artigo científico Acesso aberto
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dc.contributor.authorCouto, J.
dc.contributor.authorAntunes, S.
dc.contributor.authorFerrolho, J.
dc.contributor.authorDe La Fuente, J.
dc.contributor.authorDomingos, A.
dc.contributor.institutionInstituto de Higiene e Medicina Tropical (IHMT)
dc.contributor.institutionGlobal Health and Tropical Medicine (GHTM)
dc.contributor.institutionVector borne diseases and pathogens (VBD)
dc.contributor.pblHindawi
dc.date.accessioned2018-05-11T22:09:51Z
dc.date.available2018-05-11T22:09:51Z
dc.date.issued2017
dc.description.abstractDespite the fact that recent efforts to control/eradicate malaria have contributed to a significant decrease in the number of cases and deaths, the disease remains a global health challenge. Vaccines based on mosquito salivary gland antigens are a potential approach for reducing vector populations and malaria parasites. The Anopheles AGAP007752 gene encodes for a glucose transporter that is upregulated during Plasmodium infection, and its knockdown decreases the number of sporozoites in mosquito salivary glands. These results together with the fact that glucose is a vital source of energy suggested that a glucose transporter is a candidate protective antigen for the control of mosquito infestations and Plasmodium infection. To address this hypothesis, herein we investigate the effect of mice vaccination with an immunogenic peptide from mosquito glucose transporter on Anopheles stephensi fitness and Plasmodium berghei infection. We showed that vaccination with a peptide of glucose transporter reduced mosquito survival by 5% when compared to controls. However, the reduction in Plasmodium infection was not significant in mosquitoes fed on vaccinated mice. The effect of the peptide vaccination on mosquito survival is important to reduce infestation by malaria vectors. These results support further research on developing glucose transporter-based vaccines to reduce mosquito fitness.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent9
dc.format.extent1329958
dc.identifier.doi10.1155/2017/3428186
dc.identifier.issn2314-6133
dc.identifier.otherPURE: 3207487
dc.identifier.otherPURE UUID: 46c56448-9df2-4ef1-9108-431e64bff96b
dc.identifier.otherScopus: 85027218439
dc.identifier.otherWOS: 000405771200001
dc.identifier.otherPubMed: 28804714
dc.identifier.otherPubMedCentral: PMC5540378
dc.identifier.otherORCID: /0000-0002-5512-9093/work/70243434
dc.identifier.urihttp://www.scopus.com/inward/record.url?scp=85027218439&partnerID=8YFLogxK
dc.identifier.urlhttps://www.scopus.com/pages/publications/85027218439
dc.language.isoeng
dc.peerreviewedyes
dc.subjectTransmission-blocking vaccines
dc.subjectPlasmodium vivax
dc.subjectSalivary-glands
dc.subjectAedes aegypyi
dc.subjectMalaria
dc.subjectProtein
dc.subjectSporozoites
dc.subjectFalciparum
dc.subjectResistance
dc.subjectAlignment
dc.subjectGeneral Immunology and Microbiology
dc.subjectGeneral Biochemistry,Genetics and Molecular Biology
dc.subjectInfectious Diseases
dc.subjectInsect Science
dc.subjectSDG 3 - Good Health and Well-being
dc.titleReduction of mosquito survival in mice vaccinated with Anopheles stephensi glucose transporteren
dc.typejournal article
degois.publication.titleBioMed Research International
degois.publication.volume2017
dspace.entity.typePublication
rcaap.rightsopenAccess

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