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Zoonotic Visceral Leishmaniasis

2022-01Artigo científico Acesso aberto
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dc.contributor.authorRodrigues, Armanda Viana
dc.contributor.authorValério-Bolas, Ana
dc.contributor.authorAlexandre-Pires, Graça
dc.contributor.authorPereira, Maria Aires
dc.contributor.authorNunes, Telmo
dc.contributor.authorLigeiro, Dário
dc.contributor.authorda Fonseca, Isabel Pereira
dc.contributor.authorSantos-Gomes, Gabriela
dc.contributor.institutionVector borne diseases and pathogens (VBD)
dc.contributor.institutionGlobal Health and Tropical Medicine (GHTM)
dc.contributor.institutionInstituto de Higiene e Medicina Tropical (IHMT)
dc.contributor.pblMDPI - Multidisciplinary Digital Publishing Institute
dc.date.accessioned2022-11-03T22:13:10Z
dc.date.available2022-11-03T22:13:10Z
dc.date.issued2022-01
dc.descriptionFunding Information: Funding: This study was supported by FCT-Foundation for Science and Technology, I.P., through research grant PTDC/CVT-CVT/28908/2017 and PTDC/CVT-CVT/0228/2020, and by national funds within the scope of Centro de Investigação Interdisciplinar em Sanidade Animal (CIISA, UIDB/00276/2020) and Global Health and Tropical Medicine (GHTM, UID/04413/2020). Publisher Copyright: © 2022 by the authors. Licensee MDPI, Basel, Switzerland.
dc.description.abstractL. infantum is the aetiological agent of zoonotic visceral leishmaniasis (ZVL), a disease that affects humans and dogs. Leishmania parasites are well adapted to aggressive conditions inside the phagolysosome and can control the immune activation of macrophages (MØs). Although MØs are highly active phagocytic cells with the capacity to destroy pathogens, they additionally comprise the host cells for Leishmania infection, replication, and stable establishment in the mammal host. The present study compares, for the first time, the innate immune response to L. infantum infection of two different macrophage lineages: the blood macrophages and the liver macrophages (Kupffer cells, KC). Our findings showed that L. infantum takes advantage of the natural predisposition of blood-MØs to phagocyte pathogens. However, parasites rapidly subvert the mechanisms of MØs immune activation. On the other hand, KCs, which are primed for immune tolerance, are not extensively activated and can overcome the dormancy induced by the parasite, exhibiting a selection of immune mechanisms, such as extracellular trap formation. Altogether, KCs reveal a different pattern of response in contrast with blood-MØs when confronting L. infantum parasites. In addition, KCs response appears to be more efficient in managing parasite infection, thus contributing to the ability of the liver to naturally restrain Leishmania dissemination.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent3962814
dc.identifier.doi10.3390/biology11010100
dc.identifier.otherPURE: 46705282
dc.identifier.otherPURE UUID: 3a590839-590c-4016-b595-8f4e1e507b33
dc.identifier.otherScopus: 85122804438
dc.identifier.otherPubMed: 35053098
dc.identifier.otherPubMedCentral: PMC8773027
dc.identifier.otherORCID: /0000-0001-9264-3887/work/125066202
dc.identifier.otherORCID: /0000-0002-7080-5512/work/126583865
dc.identifier.otherORCID: /0000-0003-4261-3879/work/165069336
dc.identifier.urihttp://hdl.handle.net/10362/145212
dc.identifier.urlhttps://www.scopus.com/pages/publications/85122804438
dc.language.isoeng
dc.peerreviewedyes
dc.subjectBlood macrophages
dc.subjectInnate immunity
dc.subjectKupffer cells
dc.subjectLeishmania infantum
dc.subjectZoonotic visceral leishmaniasis
dc.subjectGeneral Biochemistry,Genetics and Molecular Biology
dc.subjectGeneral Immunology and Microbiology
dc.subjectGeneral Agricultural and Biological Sciences
dc.subjectSDG 3 - Good Health and Well-being
dc.titleZoonotic Visceral Leishmaniasisen
dc.title.subtitleNew Insights on Innate Immune Response by Blood Macrophages and Liver Kupffer Cells to Leishmania infantum Parasitesen
dc.typejournal article
degois.publication.issue1
degois.publication.titleBiology
degois.publication.volume11
dspace.entity.typePublication
rcaap.rightsopenAccess

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