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Multi-Drug and β-Lactam resistance in Escherichia Coli and Food-Borne Pathogens from animals and food in Portugal

2022-01Artigo científico Acesso aberto
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dc.contributor.authorCosta, Miguel Mendes
dc.contributor.authorCardo, Miguel
dc.contributor.authorSoares, Patricia
dc.contributor.authorD’anjo, Maria Cara
dc.contributor.authorLeite, Andreia
dc.contributor.institutionComprehensive Health Research Centre (CHRC) - Pólo ENSP
dc.contributor.institutionCentro de Investigação em Saúde Pública (CISP/PHRC)
dc.contributor.institutionEscola Nacional de Saúde Pública (ENSP)
dc.contributor.pblMDPI - Multidisciplinary Digital Publishing Institute
dc.date.accessioned2022-04-29T22:35:47Z
dc.date.available2022-04-29T22:35:47Z
dc.date.issued2022-01
dc.descriptionFunding Information: Funding: The present publication was funded by Fundação Ciência e Tecnologia, IP national support through CHRC (UIDP/04923/2020). Costa, M.M. was funded by Fundação para a Ciência e Tecnologia (PD/BD/135759/2018). Funding Information: The present publication was funded by Funda??o Ci?ncia e Tecnologia, IP national support through CHRC (UIDP/04923/2020). Costa, M.M. was funded by Funda??o para a Ci?ncia e Tecnologia (PD/BD/135759/2018). Publisher Copyright: © 2022 by the authors. Licensee MDPI, Basel, Switzerland.
dc.description.abstractAnimal and food sources are seen as a potential transmission pathway of antimicrobial resistance (AMR) to humans. The aim of this study is to describe Campylobacter, Salmonella, and commensal Escherichia coli multi-drug resistance (MDR) in the food chain between 2014 and 2019 in Portugal. AMR surveillance data from food-producing animals and food were assessed. MDR relative frequencies were estimated by bacterial genus and year. AMR profiles were created using ob-servations of resistance to antimicrobial classes from each isolate. Antimicrobial susceptibility testing results were clustered using k-modes. Clusters were described by population, AMR classification, β-lactamases, sample stage, sample type, season, and year. Overall, MDR was more prevalent for E. coli, ranging from 74–90% in animal and 94–100% in food samples. MDR was found to be more widespread in resistance profiles that were common among E. coli and Salmonella isolates and in those exclusively observed for E. coli, frequently including (fluoro)quinolones and cephalosporins resistance. β-lactam resistance was observed around 75% to 3rd/4th-generation cephalosporins in E. coli. Clusters suggest an escalating MDR behaviour from farm to post-farm stages in all bacteria and that Salmonella (fluoro)quinolones resistance may be associated with broilers. These findings support policy and decision making to tackle MDR in farm and post-farm stages.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent788014
dc.identifier.doi10.3390/antibiotics11010090
dc.identifier.issn2079-6382
dc.identifier.otherPURE: 43565339
dc.identifier.otherPURE UUID: 03ed6ca7-74a1-4599-afea-1eac95ab5c2b
dc.identifier.otherScopus: 85123264853
dc.identifier.otherPubMed: 35052967
dc.identifier.otherPubMedCentral: PMC8773433
dc.identifier.otherORCID: /0000-0003-0843-0630/work/112295031
dc.identifier.urihttp://hdl.handle.net/10362/137174
dc.identifier.urlhttps://www.scopus.com/pages/publications/85123264853
dc.language.isoeng
dc.peerreviewedyes
dc.subjectFood safety
dc.subjectFood-producing animals
dc.subjectMulti-drug resistance
dc.subjectSurveillance
dc.subjectZoonotic bacteria
dc.subjectMicrobiology
dc.subjectBiochemistry
dc.subjectPharmacology, Toxicology and Pharmaceutics(all)
dc.subjectMicrobiology (medical)
dc.subjectInfectious Diseases
dc.subjectPharmacology (medical)
dc.subjectSDG 3 - Good Health and Well-being
dc.titleMulti-Drug and β-Lactam resistance in Escherichia Coli and Food-Borne Pathogens from animals and food in Portugalen
dc.typejournal article
degois.publication.issue1
degois.publication.titleAntibiotics
degois.publication.volume11
dspace.entity.typePublication
rcaap.rightsopenAccess

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