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Evaluation of tissue and circulating mir-21 as potential biomarker of response to chemoradiotherapy in rectal cancer

2020-09Artigo científico Acesso aberto
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dc.contributor.authorOurô, Susana
dc.contributor.authorMourato, Cláudia
dc.contributor.authorFerreira, Marisa P.
dc.contributor.authorAlbergaria, Diogo
dc.contributor.authorCardador, André
dc.contributor.authorCastro, Rui E.
dc.contributor.authorMaio, Rui
dc.contributor.authorRodrigues, Cecília M.P.
dc.contributor.institutionNOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
dc.contributor.pblMolecular Diversity Preservation International (MDPI)
dc.date.accessioned2020-11-03T23:59:11Z
dc.date.available2020-11-03T23:59:11Z
dc.date.issued2020-09
dc.descriptionThis research received funding from European Structural & Investment Funds through the COMPETE Programme—Programa Operacional Regional de Lisboa—Programme Grant LISBOA-01-0145-FEDER-016405,and from National Funds through FCT—Fundação para a Ciência e a Tecnologia—Programme Grant SAICTPAC/0019/2015.
dc.description.abstractResponse to chemoradiotherapy (CRT) in patients with locally advanced rectal cancer (RC) is quite variable and it is urgent to find predictive biomarkers of response. We investigated miR-21 as tissue and plasma biomarker of response to CRT in a prospective cohort of RC patients; The expression of miR-21 was analyzed in pre-and post-CRT rectal tissue and plasma in 37 patients with RC. Two groups were defined: Pathological responders (TRG 0, 1 and 2) and non-responders (TRG 3). The association between miR-21, clinical and oncological outcomes was assessed; miR-21 was upregulated in tumor tissue and we found increased odds of overexpression in pre-CRT tumor tissue (OR: 1.63; 95% CI: 0.40–6.63, p = 0.498) and pre-CRT plasma (OR: 1.79; 95% CI: 0.45–7.19, p = 0.414) of non-responders. The overall recurrence risk increased with miR-21 overexpression in pre-CRT tumor tissue (HR: 2.175, p = 0.37); Significantly higher miR-21 expression is observed in tumor tissue comparing with non-neoplastic. Increased odds of non-response is reported in patients expressing higher miR-21, although without statistical significance. This is one of the first studies on circulating miR-21 as a potential biomarker of response to CRT in RC patients.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent953461
dc.identifier.doi10.3390/ph13090246
dc.identifier.issn1424-8247
dc.identifier.otherPURE: 19928724
dc.identifier.otherPURE UUID: b64341ae-5c8b-4f36-8f1b-21c626ad560f
dc.identifier.otherScopus: 85090841569
dc.identifier.otherPubMed: 32937907
dc.identifier.otherWOS: 000581335800001
dc.identifier.urihttp://hdl.handle.net/10362/106592
dc.identifier.urlhttps://www.scopus.com/pages/publications/85090841569
dc.language.isoeng
dc.peerreviewedyes
dc.subjectBiomarkers
dc.subjectChemoradiotherapy
dc.subjectMiR-21
dc.subjectRectal cancer
dc.subjectTherapy response
dc.subjectTumor regression grade
dc.subjectMolecular Medicine
dc.subjectPharmaceutical Science
dc.subjectSDG 3 - Good Health and Well-being
dc.titleEvaluation of tissue and circulating mir-21 as potential biomarker of response to chemoradiotherapy in rectal canceren
dc.typejournal article
degois.publication.issue9
degois.publication.titlePharmaceuticals
degois.publication.volume13
dspace.entity.typePublication
rcaap.rightsopenAccess

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