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Preliminary structural characterization of human SOUL, a haem-binding protein

2009-01-01Artigo científico Acesso aberto
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dc.contributor.authorFreire, Filipe
dc.contributor.authorRomão, Maria João
dc.contributor.authorMacEdo, Anjos L.
dc.contributor.authorAveiro, Susana S.
dc.contributor.authorGoodfellow, Brian J.
dc.contributor.authorCarvalho, Ana Luísa
dc.contributor.institutionDQ - Departamento de Química
dc.contributor.institutionCQFB-REQUIMTE - Centro de Química Fina e Biotecnologia (Lab. Associado REQUIMTE)
dc.contributor.pblBlackwell Publishing Ltd
dc.date.accessioned2019-03-11T23:15:21Z
dc.date.available2019-03-11T23:15:21Z
dc.date.issued2009-01-01
dc.descriptionThe authors acknowledge financial support from Fundacao para a Ciencia e Tecnologia, Portugal through grant SFRH/BPD/30239/2006. The authors also acknowledge the ESRF, Grenoble (beamlines ID14- EH2, ID14- EH4, ID23- EH1 and ID-29) for access and technical support during data collection.
dc.description.abstractHuman SOUL (hSOUL) is a 23 kDa haem-binding protein that was first identified as the PP23 protein isolated from human full-term placentas. Here, the overexpression, purification and crystallization of hSOUL are reported. The crystals belonged to space group P6422, with unit-cell parameters a = b = 145, c = 60 Å and one protein molecule in the asymmetric unit. X-ray diffraction data were collected to 3.5 Å resolution at the ESRF. A preliminary model of the three-dimensional structure of hSOUL was obtained by molecular replacement using the structures of murine p22HBP (PDB codes 2gov and 2hva), obtained by solution NMR, as search models.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent4
dc.format.extent242672
dc.identifier.doi10.1107/S174430910902291X
dc.identifier.issn1744-3091
dc.identifier.otherPURE: 12011100
dc.identifier.otherPURE UUID: a3aaaaf8-7787-43e1-8cf9-4d87e6199ed6
dc.identifier.otherScopus: 68149089746
dc.identifier.otherPubMed: 19574650
dc.identifier.otherPubMedCentral: PMC2705645
dc.identifier.otherWOS: 000267530000018
dc.identifier.otherORCID: /0000-0002-3004-0543/work/55386355
dc.identifier.otherORCID: /0000-0002-3824-0240/work/55386447
dc.identifier.urihttp://www.scopus.com/inward/record.url?scp=68149089746&partnerID=8YFLogxK
dc.identifier.urlhttps://www.scopus.com/pages/publications/68149089746
dc.language.isoeng
dc.peerreviewedyes
dc.relationinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F30239%2F2006/PT
dc.relationinfo:eu-repo/grantAgreement/FCT/5876-PPCDTI/64203/PT
dc.relationinfo:eu-repo/grantAgreement/FCT/Concurso para Projectos de I&D em todos os Domínios Científicos - 2006/PTDC%2FQUI%2F64203%2F2006/PT
dc.relationStructural and functional studies of the SOUL/HBP family of heme binding proteins
dc.subjectHaem-binding proteins
dc.subjectSOUL
dc.subjectBiophysics
dc.subjectStructural Biology
dc.subjectBiochemistry
dc.subjectGenetics
dc.subjectCondensed Matter Physics
dc.titlePreliminary structural characterization of human SOUL, a haem-binding proteinen
dc.typejournal article
degois.publication.firstPage723
degois.publication.issue7
degois.publication.lastPage726
degois.publication.titleActa Crystallographica Section F: Structural Biology and Crystallization Communications
degois.publication.volume65
dspace.entity.typePublication
oaire.awardNumberSFRH/BD/30239/2006
oaire.awardNumber64203
oaire.awardNumberPTDC/QUI/64203/2006
oaire.awardTitleStructural and functional studies of the SOUL/HBP family of heme binding proteins
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F30239%2F2006/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876-PPCDTI/64203/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/Concurso para Projectos de I&D em todos os Domínios Científicos - 2006/PTDC%2FQUI%2F64203%2F2006/PT
oaire.fundingStreamSFRH
oaire.fundingStream5876-PPCDTI
oaire.fundingStreamConcurso para Projectos de I&D em todos os Domínios Científicos - 2006
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccess
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relation.isProjectOfPublication78c14e00-143b-416a-ae2f-ea3f8dfa0e17
relation.isProjectOfPublication58c8417b-4b88-4a75-a4ab-f3d0ddc0a9a7
relation.isProjectOfPublication.latestForDiscoverya594d15d-ba11-416b-b35d-931b31f90494

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