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Rapid determination of anti-tuberculosis drug resistance from whole-genome sequences

2015-05-27Artigo científico Acesso aberto
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dc.contributor.authorColl, Francesc
dc.contributor.authorMcNerney, Ruth
dc.contributor.authorPreston, Mark D.
dc.contributor.authorGuerra-Assunção, José Afonso
dc.contributor.authorWarry, Andrew
dc.contributor.authorHill-Cawthorne, Grant
dc.contributor.authorMallard, Kim
dc.contributor.authorNair, Mridul
dc.contributor.authorMiranda, Anabela
dc.contributor.authorAlves, Adriana
dc.contributor.authorPerdigão, João
dc.contributor.authorViveiros, Miguel
dc.contributor.authorPortugal, Isabel
dc.contributor.authorHasan, Zahra
dc.contributor.authorHasan, Rumina
dc.contributor.authorGlynn, Judith R.
dc.contributor.authorMartin, Nigel
dc.contributor.authorPain, Arnab
dc.contributor.authorClark, Taane G.
dc.contributor.institutionInstituto de Higiene e Medicina Tropical (IHMT)
dc.contributor.institutionTB, HIV and opportunistic diseases and pathogens (THOP)
dc.contributor.institutionGlobal Health and Tropical Medicine (GHTM)
dc.contributor.pblBioMed Central (BMC)
dc.date.accessioned2018-05-14T22:01:34Z
dc.date.available2018-05-14T22:01:34Z
dc.date.issued2015-05-27
dc.descriptionPMID: 26019726 WOS:000355073700001
dc.description.abstractMycobacterium tuberculosis drug resistance (DR) challenges effective tuberculosis disease control. Current molecular tests examine limited numbers of mutations, and although whole genome sequencing approaches could fully characterise DR, data complexity has restricted their clinical application. A library (1,325 mutations) predictive of DR for 15 anti-tuberculosis drugs was compiled and validated for 11 of them using genomic-phenotypic data from 792 strains. A rapid online 'TB-Profiler' tool was developed to report DR and strain-type profiles directly from raw sequences. Using our DR mutation library, in silico diagnostic accuracy was superior to some commercial diagnostics and alternative databases. The library will facilitate sequence-based drug-susceptibility testing.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent1200673
dc.identifier.doi10.1186/s13073-015-0164-0
dc.identifier.otherPURE: 1645018
dc.identifier.otherPURE UUID: d8f4e4e6-76c2-4f7c-bb4f-15e9c0e8e9ab
dc.identifier.otherScopus: 84939257684
dc.identifier.otherWOS: 000355073700001
dc.identifier.otherPubMed: 26019726
dc.identifier.otherORCID: /0000-0001-9676-6251/work/45270609
dc.identifier.urihttp://www.scopus.com/inward/record.url?scp=84939257684&partnerID=8YFLogxK
dc.identifier.urlhttps://www.scopus.com/pages/publications/84939257684
dc.language.isoeng
dc.peerreviewedyes
dc.subjectGenetics(clinical)
dc.subjectGenetics
dc.subjectMolecular Biology
dc.subjectMolecular Medicine
dc.subjectSDG 3 - Good Health and Well-being
dc.titleRapid determination of anti-tuberculosis drug resistance from whole-genome sequencesen
dc.typejournal article
degois.publication.issue1
degois.publication.titleGenome Medicine
degois.publication.volume7
dspace.entity.typePublication
rcaap.rightsopenAccess

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