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Population genomic evidence of structured and connected Plasmodium vivax populations under host selection in Latin America

2024-03-24Artigo científico Acesso aberto
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dc.contributor.authorKattenberg, Johanna Helena
dc.contributor.authorMonsieurs, Pieter
dc.contributor.authorde Meyer, Julie
dc.contributor.authorDe Meulenaere, Katlijn
dc.contributor.authorSauve, Erin
dc.contributor.authorde Oliveira, Thaís C.
dc.contributor.authorFerreira, Marcelo U.
dc.contributor.authorGamboa, Dionicia
dc.contributor.authorRosanas-Urgell, Anna
dc.contributor.institutionInstituto de Higiene e Medicina Tropical (IHMT)
dc.contributor.institutionGlobal Health and Tropical Medicine (GHTM)
dc.contributor.institutionIndividual Health Care (IHC)
dc.contributor.pblWiley-Blackwell
dc.date.accessioned2024-06-19T00:47:15Z
dc.date.available2024-06-19T00:47:15Z
dc.date.issued2024-03-24
dc.descriptionConselho Nacional de Desenvolvimento Cientifico e Tecnologico; Department of Economy, Science and Innovation in Flanders; Fundacaco de Amparo ac Pesquisa do Estado de Saco Paulo, Grant/Award Number: 2016/187409; Fonds Wetenschappelijk Onderzoek,Grant/Award Number: 1S48419N and 1SC5522N; the Belgium Development Cooperation (DGD) under the Framework Agreement Program, Grant/Award Number: FA3III 2014 2016, FA4 2017 2021 and FA5 2022 2026; Research Foundation Flanders (FWO) and the Flemish Government; Foundation for the National Institutes of Health, Grant/Award Number: U19 AI089681; Fundacaco para a Ciencia e a Tecnologia, Portugal, Grant/Award Number: UID/04413/2020 © 2024 The Authors. Ecology and Evolution published by John Wiley & Sons Ltd.
dc.description.abstractPathogen genomic epidemiology has the potential to provide a deep understanding of population dynamics, facilitating strategic planning of interventions, monitoring their impact, and enabling timely responses, and thereby supporting control and elimination efforts of parasitic tropical diseases. Plasmodium vivax, responsible for most malaria cases outside Africa, shows high genetic diversity at the population level, driven by factors like sub-patent infections, a hidden reservoir of hypnozoites, and early transmission to mosquitoes. While Latin America has made significant progress in controlling Plasmodium falciparum, it faces challenges with residual P. vivax. To characterize genetic diversity and population structure and dynamics, we have analyzed the largest collection of P. vivax genomes to date, including 1474 high-quality genomes from 31 countries across Asia, Africa, Oceania, and America. While P. vivax shows high genetic diversity globally, Latin American isolates form a distinctive population, which is further divided into sub-populations and occasional clonal pockets. Genetic diversity within the continent was associated with the intensity of transmission. Population differentiation exists between Central America and the North Coast of South America, vs. the Amazon Basin, with significant gene flow within the Amazon Basin, but limited connectivity between the Northwest Coast and the Amazon Basin. Shared genomic regions in these parasite populations indicate adaptive evolution, particularly in genes related to DNA replication, RNA processing, invasion, and motility - crucial for the parasite's survival in diverse environments. Understanding these population-level adaptations is crucial for effective control efforts, offering insights into potential mechanisms behind drug resistance, immune evasion, and transmission dynamics.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent7847185
dc.identifier.doi10.1002/ece3.11103
dc.identifier.issn2045-7758
dc.identifier.otherPURE: 91565080
dc.identifier.otherPURE UUID: 7fa66cb9-e45a-4215-945e-97d4de010658
dc.identifier.otherPubMed: 38529021
dc.identifier.otherScopus: 85188647250
dc.identifier.otherWOS: 001189896800001
dc.identifier.otherPubMedCentral: PMC10961478
dc.identifier.otherORCID: /0000-0002-5293-9090/work/161898430
dc.identifier.urihttp://hdl.handle.net/10362/168751
dc.language.isoeng
dc.peerreviewedyes
dc.subjectPlasmodium vivax
dc.subjectgenomic epidemiology
dc.subjectnatural selection
dc.subjectparasitology
dc.subjectphylogeography
dc.subjectpopulation dynamics
dc.subjectInfectious Diseases
dc.subjectGeneral Biochemistry,Genetics and Molecular Biology
dc.subjectMicrobiology (medical)
dc.subjectParasitology
dc.subjectSDG 3 - Good Health and Well-being
dc.titlePopulation genomic evidence of structured and connected Plasmodium vivax populations under host selection in Latin Americaen
dc.typejournal article
degois.publication.issue3
degois.publication.titleEcology and Evolution
degois.publication.volume14
dspace.entity.typePublication
rcaap.rightsopenAccess

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