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Defining Bath Ankylosing Spondylitis Disease Activity Index Cut-off Values for Disease Activity States in a Multinational European Cohort of Patients With Axial Spondyloarthritis

2025-12Artigo científico Acesso aberto
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dc.contributor.authorGeorgiadis, Stylianos
dc.contributor.authorØrnbjerg, Lykke Midtbøll
dc.contributor.authorMichelsen, Brigitte
dc.contributor.authorKvien, Tore K.
dc.contributor.authorShoae Kazemi, Mehrdad
dc.contributor.authorZávada, Jakub
dc.contributor.authorPavelka, Karel
dc.contributor.authorGlintborg, Bente
dc.contributor.authorLoft, Anne Gitte
dc.contributor.authorReich, Andreas
dc.contributor.authorRegierer, Anne C.
dc.contributor.authorRodrigues, Ana Maria
dc.contributor.authorSantos, Maria José
dc.contributor.authorRutanen, Jarno
dc.contributor.authorKuusalo, Laura
dc.contributor.authorCiurea, Adrian
dc.contributor.authorNissen, Michael J.
dc.contributor.authorGudbjornsson, Bjorn
dc.contributor.authorPálsson, Ólafur
dc.contributor.authorRotar, Žiga
dc.contributor.authorPerdan Pirkmajer, Katja
dc.contributor.authorDi Giuseppe, Daniela
dc.contributor.authorØstergaard, Mikkel
dc.contributor.authorHetland, Merete Lund
dc.contributor.institutionNOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
dc.contributor.institutionComprehensive Health Research Centre (CHRC) - pólo NMS
dc.contributor.pblJohn Wiley and Sons Inc.
dc.date.accessioned2026-01-14T15:52:11Z
dc.date.available2026-01-14T15:52:11Z
dc.date.issued2025-12
dc.descriptionPublisher Copyright: © 2025 The Author(s). ACR Open Rheumatology published by Wiley Periodicals LLC on behalf of American College of Rheumatology.
dc.description.abstractObjective: The Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) is widely used for assessing disease activity in patients with axial spondyloarthritis (axSpA), particularly in settings where markers of inflammation are unavailable. As no consensus on BASDAI cut-off values exists for disease activity states in axSpA, we aimed to develop and validate such cut-offs against external criteria. Methods: Routine care patients with axSpA initiating a biologic disease-modifying antirheumatic drug in eight European registries were included. Receiver operating characteristic analyses against external criteria were performed to determine optimal BASDAI values for separating remission, low disease activity (LDA), high disease activity (HDA), and very high disease activity (VHDA). Follow-up data at 6 months were used to select BASDAI cut-off values between remission and LDA and between LDA and HDA, whereas baseline data were used to select the cut-off for VHDA. The level of agreement between disease activity states based on BASDAI and Axial Spondyloarthritis Disease Activity Score (ASDAS) cut-off values was assessed using the proportion of discordance and weighted kappa. Results: In this cohort of 4,633 patients, the optimal BASDAI cut-off values between remission, LDA, HDA and VHDA were estimated to be <1.3, <2.5, and >5.3. The proportions of discordance between BASDAI and ASDAS disease activity states were 27.6% (weighted κ = 0.48) in baseline data and 37.6% (weighted κ = 0.28) in 6-month data. Conclusion: BASDAI cut-off values for separating remission, LDA, HDA and VHDA were estimated in >4,600 patients. These cut-off values can be used for assessing disease activity and monitoring patients with axSpA, particularly when laboratory markers are unavailable.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent1204745
dc.identifier.doi10.1002/acr2.70125
dc.identifier.issn2578-5745
dc.identifier.otherPURE: 147373545
dc.identifier.otherPURE UUID: 131aac6e-3deb-46db-acad-056079c926d8
dc.identifier.otherScopus: 105023665258
dc.identifier.urihttp://hdl.handle.net/10362/199002
dc.identifier.urlhttps://www.scopus.com/pages/publications/105023665258
dc.language.isoeng
dc.peerreviewedyes
dc.subjectRheumatology
dc.titleDefining Bath Ankylosing Spondylitis Disease Activity Index Cut-off Values for Disease Activity States in a Multinational European Cohort of Patients With Axial Spondyloarthritisen
dc.typejournal article
degois.publication.issue12
degois.publication.titleACR Open Rheumatology
degois.publication.volume7
dspace.entity.typePublication
rcaap.rightsopenAccess

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