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Cytokine Dynamics in Acute Pancreatitis

2024-04Artigo científico Acesso aberto
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dc.contributor.authorMalheiro, Filipa
dc.contributor.authorÂngelo-Dias, Miguel
dc.contributor.authorMalheiro, Filipa
dc.contributor.authorLopes, Teresa
dc.contributor.authorMartins, Catarina Gregório
dc.contributor.authorÂngelo-Dias, Miguel
dc.contributor.authorBorrego, Luis Miguel
dc.contributor.authorMartins, Catarina
dc.contributor.authorBORREGO, LUIS MIGUEL
dc.contributor.institutionNOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
dc.contributor.institutionComprehensive Health Research Centre (CHRC) - pólo NMS
dc.contributor.pblMDPI - Multidisciplinary Digital Publishing Institute
dc.date.accessioned2024-05-07T00:33:13Z
dc.date.available2024-05-07T00:33:13Z
dc.date.issued2024-04
dc.description.abstractBackground: Acute pancreatitis (AP) is an inflammatory disease of the pancreas with incompletely known pathogenic mechanisms. This study aimed to explore the temporal changes in serum cytokines in patients with AP and to assess the association of these changes with disease severity. Methods: Fifty patients hospitalized with AP were enrolled, and their serum cytokine levels were analyzed at four different time points. A healthy control (HC) group of 30 outpatients was included. Results: AP patients showed increased levels of interleukin (IL)-6, IL-8, IL-10, vascular endothelial growth factor (VEGF), tumor necrosis factor (TNF)-alpha, and monocyte chemoattractant protein (MCP)-1 at admission when compared with HC. IL-6, VEGF, and EGF remained elevated 1 month after hospitalization and 6 months after discharge. Conclusions the Bedside Index of Severity in Acute Pancreatitis (BISAP) and severity classification of the revised Atlanta classification system, IL-6 and VEGF, determined 48 h after hospitalization, were the two cytokines consistently elevated in the most severe patients. Increased levels of IL-4, IL-6, IL-10, and TNF-alpha at admission and MCP-1 48 h after admission are also related to the length of hospital stay. Conclusions: Our study highlights the role cytokines play in the pathogenesis of AP and can be useful in the development of future drug trials for AP.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent4872642
dc.identifier.doi10.3390/jcm13082287
dc.identifier.issn2077-0383
dc.identifier.otherPURE: 89928102
dc.identifier.otherPURE UUID: a6dd4d16-d9ba-4b1f-a0a2-d549df90cc29
dc.identifier.otherScopus: 85191293249
dc.identifier.otherPubMed: 38673560
dc.identifier.otherORCID: /0000-0003-4708-438X/work/159104581
dc.identifier.otherORCID: /0000-0003-0353-0421/work/159104897
dc.identifier.otherORCID: /0000-0001-9933-4075/work/206216929
dc.identifier.urihttp://hdl.handle.net/10362/167071
dc.identifier.urlhttps://www.scopus.com/pages/publications/85191293249
dc.identifier.urlhttps://pubmed.ncbi.nlm.nih.gov/38673560/
dc.language.isoeng
dc.peerreviewedyes
dc.subjectacute pancreatitis
dc.subjectbiomarker
dc.subjectcytokines
dc.subjectepidermal growth factor
dc.subjectIL-6
dc.subjectmonocyte chemoattractant protein-1
dc.subjectseverity
dc.subjectvascular endothelial growth factor
dc.subjectGeneral Medicine
dc.titleCytokine Dynamics in Acute Pancreatitisen
dc.title.subtitleThe Quest for Biomarkers from Acute Disease to Disease Resolutionen
dc.typejournal article
degois.publication.issue8
degois.publication.titleJournal of Clinical Medicine
degois.publication.volume13
dspace.entity.typePublication
person.familyNameMalheiro
person.familyNameDias
person.familyNameMartins
person.familyNameBORREGO
person.givenNameFilipa
person.givenNameMiguel
person.givenNameCatarina
person.givenNameLUIS MIGUEL
person.identifier2615881
person.identifier.ciencia-idB51E-B9D5-3AA5
person.identifier.ciencia-id411B-1E08-D4F7
person.identifier.ciencia-id4119-915F-EF0F
person.identifier.orcid0000-0003-0664-2576
person.identifier.orcid0000-0001-9933-4075
person.identifier.orcid0000-0003-0353-0421
person.identifier.orcid0000-0003-4708-438X
person.identifier.scopus-author-id8346933500
rcaap.rightsopenAccess
relation.isAuthorOfPublication86545a90-e3eb-40ee-bd9e-acbf048bbbd2
relation.isAuthorOfPublication34f362b7-efa5-4259-a91e-f5f6dc6e0b95
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relation.isAuthorOfPublication027a8b74-0ce7-4daa-9ef4-917b9ec6f95a
relation.isAuthorOfPublication.latestForDiscovery86545a90-e3eb-40ee-bd9e-acbf048bbbd2

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