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Torquetenovirus viral load is associated with anti-spike antibody response in SARS-CoV-2 mRNA BNT162b2 vaccinated kidney transplant patients

2022-12Artigo científico Acesso aberto
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dc.contributor.authorQuerido, Sara
dc.contributor.authorAdragão, Teresa
dc.contributor.authorPinto, Iola
dc.contributor.authorOrmonde, Carolina
dc.contributor.authorPapoila, Ana Luísa
dc.contributor.authorPapoila, A.L.
dc.contributor.authorPessanha, Maria Ana
dc.contributor.authorGomes, Perpétua
dc.contributor.authorFerreira, Sílvia
dc.contributor.authorFigueira, João Mário
dc.contributor.authorCardoso, Conceição
dc.contributor.authorViana, João Faro
dc.contributor.authorWeigert, André
dc.contributor.institutionFaculdade de Ciências e Tecnologia (FCT)
dc.contributor.institutionNOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
dc.contributor.pblBlackwell Publishing Ltd
dc.date.accessioned2023-03-31T22:18:41Z
dc.date.available2023-03-31T22:18:41Z
dc.date.issued2022-12
dc.description.abstractIntroduction: Kidney transplant patients (KT) are at high risk for severe COVID-19 and presented attenuated antibody responses to vaccination when compared to immunocompetent individuals. Torquetenovirus (TTV) has recently gained attention as a potential surrogate marker of the net state of immunosuppression. We evaluated the association between pre-vaccination TTV viral load and anti-spike total antibody response to SARS-CoV-2 vaccination in KT. Material and Methods: The 114 adult KT recipients enrolled in this prospective single-center cohort study received two doses of SARS-CoV-2 mRNA BNT162b2 vaccine. Serum samples were collected immediately before vaccination at the days when patients received both the first (T0) and the second dose (T1) and 16–45 days after the second dose (T2). Primary endpoint was the development of anti-spike total antibodies after vaccination. Demographic, clinical, and laboratorial parameters were compared between patients with and without detectable SARS-CoV-2 antibodies at T2. Results: Ninety-nine patients (86.8%) were naïve for SARS-CoV-2 before vaccination. Fifty-six (56.6%) patients developed anti-spike total antibodies at T2. The use of mTOR inhibitors was associated with a favorable response (p =.005); conversely, mycophenolic acid (MPA) was associated with a negative response (p =.006). In a multivariable model, the presence of TTV at T0 ≥ 3.36 log10 cp/ml was associated with unfavorable vaccine response (OR: 5.40; 95% CI: 1.47–19.80; p =.011), after adjusting for age and eGFR at T0. Conclusions: Higher TTV viral loads before vaccination are associated with reduced anti-spike total antibody response in SARS-CoV-2 mRNA BNT162b2 vaccinated KT patients. The association between TTV viral load and vaccine response may be an added-value in the optimization of vaccination regimens in KT.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent416926
dc.identifier.doi10.1111/ctr.14825
dc.identifier.issn0902-0063
dc.identifier.otherPURE: 48188627
dc.identifier.otherPURE UUID: afe8b8dd-6044-4e3f-a6cb-66bd7990f93c
dc.identifier.otherScopus: 85142601411
dc.identifier.otherPubMed: 36301197
dc.identifier.otherWOS: 000889241500001
dc.identifier.urihttp://hdl.handle.net/10362/151469
dc.identifier.urlhttps://www.scopus.com/pages/publications/85142601411
dc.language.isoeng
dc.peerreviewedyes
dc.subjectkidney transplantation
dc.subjectSARS-CoV-2
dc.subjecttorquetenovirus
dc.subjectvaccine
dc.subjectTransplantation
dc.subjectSDG 3 - Good Health and Well-being
dc.titleTorquetenovirus viral load is associated with anti-spike antibody response in SARS-CoV-2 mRNA BNT162b2 vaccinated kidney transplant patientsen
dc.typejournal article
degois.publication.issue12
degois.publication.titleClinical Transplantation
degois.publication.volume36
dspace.entity.typePublication
person.familyNamePapoila
person.givenNameAna Luisa
person.identifier.ciencia-id251C-0273-1068
person.identifier.orcid0000-0002-2918-8364
person.identifier.ridS-2515-2016
person.identifier.scopus-author-id6507532321
rcaap.rightsopenAccess
relation.isAuthorOfPublication5ce1bd05-e7a4-4bd0-9527-f511c0889095
relation.isAuthorOfPublication.latestForDiscovery5ce1bd05-e7a4-4bd0-9527-f511c0889095

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