Logo do repositório
 
Publicação

Tick-pathogen interactions and vector competence:

2017-04-07Recensão Acesso aberto
Ver registo simples
dc.contributor.authorde la Fuente, José
dc.contributor.authorAntunes, Sandra
dc.contributor.authorBonnet, Sarah
dc.contributor.authorCabezas-Cruz, Alejandro
dc.contributor.authorDomingos, Ana G.
dc.contributor.authorEstrada-Peña, Agustín
dc.contributor.authorJohnson, Nicholas
dc.contributor.authorKocan, Katherine M.
dc.contributor.authorMansfield, Karen L.
dc.contributor.authorNijhof, Ard M.
dc.contributor.authorPapa, Anna
dc.contributor.authorRudenko, Nataliia
dc.contributor.authorVillar, Margarita
dc.contributor.authorAlberdi, Pilar
dc.contributor.authorTorina, Alessandra
dc.contributor.authorAyllón, Nieves
dc.contributor.authorVancova, Marie
dc.contributor.authorGolovchenko, Maryna
dc.contributor.authorGrubhoffer, Libor
dc.contributor.authorCaracappa, Santo
dc.contributor.authorFooks, Anthony R.
dc.contributor.authorGortazar, Christian
dc.contributor.authorRego, Ryan O.M.
dc.contributor.institutionInstituto de Higiene e Medicina Tropical (IHMT)
dc.contributor.institutionGlobal Health and Tropical Medicine (GHTM)
dc.contributor.institutionVector borne diseases and pathogens (VBD)
dc.contributor.pblFrontiers Media
dc.date.accessioned2018-05-10T22:15:40Z
dc.date.available2018-05-10T22:15:40Z
dc.date.issued2017-04-07
dc.description.abstractTicks and the pathogens they transmit constitute a growing burden for human and animal health worldwide. Vector competence is a component of vectorial capacity and depends on genetic determinants affecting the ability of a vector to transmit a pathogen. These determinants affect traits such as tick-host-pathogen and susceptibility to pathogen infection. Therefore, the elucidation of the mechanisms involved in tick-pathogen interactions that affect vector competence is essential for the identification of molecular drivers for tick-borne diseases. In this review, we provide a comprehensive overview of tick-pathogen molecular interactions for bacteria, viruses, and protozoa affecting human and animal health. Additionally, the impact of tick microbiome on these interactions was considered. Results show that different pathogens evolved similar strategies such as manipulation of the immune response to infect vectors and facilitate multiplication and transmission. Furthermore, some of these strategies may be used by pathogens to infect both tick and mammalian hosts. Identification of interactions that promote tick survival, spread, and pathogen transmission provides the opportunity to disrupt these interactions and lead to a reduction in tick burden and the prevalence of tick-borne diseases. Targeting some of the similar mechanisms used by the pathogens for infection and transmission by ticks may assist in development of preventative strategies against multiple tick-borne diseases.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent13
dc.format.extent1608776
dc.identifier.doi10.3389/fcimb.2017.00114
dc.identifier.issn2235-2988
dc.identifier.otherPURE: 3198274
dc.identifier.otherPURE UUID: 148cda41-b849-4462-a21c-9bb5d34c027b
dc.identifier.otherScopus: 85027443270
dc.identifier.otherPubMed: 28439499
dc.identifier.otherWOS: 000398625000001
dc.identifier.otherPubMedCentral: PMC5383669
dc.identifier.urihttp://www.scopus.com/inward/record.url?scp=85027443270&partnerID=8YFLogxK
dc.identifier.urlhttps://www.scopus.com/pages/publications/85027443270
dc.language.isoeng
dc.peerreviewedyes
dc.subjectAnaplasma
dc.subjectBabesia
dc.subjectBorrelia
dc.subjectFlavivirus
dc.subjectImmunology
dc.subjectMicrobiome
dc.subjectTick
dc.subjectVaccine
dc.subjectMicrobiology
dc.subjectImmunology
dc.subjectMicrobiology (medical)
dc.subjectInfectious Diseases
dc.subjectSDG 3 - Good Health and Well-being
dc.titleTick-pathogen interactions and vector competence:en
dc.title.subtitleidentification of molecular drivers for tick-borne diseasesen
dc.typereview
degois.publication.firstPage114
degois.publication.issueAPR
degois.publication.lastPage127
degois.publication.titleFrontiers in Cellular and Infection Microbiology
degois.publication.volume7
dspace.entity.typePublication
rcaap.rightsopenAccess

Ficheiros

Principais
A mostrar 1 - 1 de 1
Miniatura
Nome:
Tick_Pathogen_Interactions_and_Vector_Competence.pdf
Tamanho:
1.53 MB
Formato:
Adobe Portable Document Format
Ver/Abrir

Coleções

IHMT: PM - Artigos em revista internacional com arbitragem científica