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Differential Effects of the Human Digestive Process on Petroleum- and Bio-Based Microplastics Following an In Vitro Approach to Determine Polymer Integrity and Seafood Digestibility

2025-11-03Artigo científico Acesso aberto
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dc.contributor.authorBolotas, Daniel
dc.contributor.authorGomes, Rita V. C.
dc.contributor.authorAmbrosino, Ana C.
dc.contributor.authorLopes, Clara
dc.contributor.authorRaimundo, Joana
dc.contributor.authorLoureiro, Mónica V.
dc.contributor.authorPereira, Alda S.
dc.contributor.authorSantana, Pedro
dc.contributor.authorMarques, António
dc.contributor.authorRepolho, Tiago
dc.contributor.authorMaulvault, Ana Luísa
dc.contributor.institutionDQ - Departamento de Química
dc.contributor.institutionUCIBIO - Applied Molecular Biosciences Unit
dc.contributor.pblMDPI - Multidisciplinary Digital Publishing Institute
dc.date.accessioned2026-02-11T17:22:01Z
dc.date.available2026-02-11T17:22:01Z
dc.date.issued2025-11-03
dc.descriptionPublisher Copyright: © 2025 by the authors.
dc.description.abstractPlastic pollution is a major environmental concern. In humans, ingestion through contaminated seafood is a recognized exposure route to microplastics, which may impact gut health. However, the extent to which microplastics interfere with digestion and nutrient absorption remains unclear. To this end, the present work aimed to assess, for the first time, the influence of microplastic particles (polyethylene terephthalate, PET, and polylactic acid, PLA) on the digestibility of three selected seafood species (gilthead seabream, Sparus aurata; Atlantic salmon, Salmo salar; and hard clam, Mercenaria mercenaria) using an in vitro human digestion model. Furthermore, this study evaluated the potential degradability of microplastics along the gastrointestinal tract and examined how particle type and exposure level (10 or 20 particles) may influence seafood digestibility. Protein digestibility in S. aurata and S. salar filets was ~86%, while in M. mercenaria it was ~73%, regardless of microplastic presence or quantity. PET and PLA integrity was affected differently by digestion, with PLA showing greater surface degradation. These findings provide preliminary insight into the mutual interactions between microplastics and the human digestive process, highlighting the importance for further research into how the leaching of plastics additives may or may not influence the bioaccessibility of essential nutrients.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent16
dc.format.extent5874277
dc.identifier.doi10.3390/microplastics4040083
dc.identifier.issn2673-8929
dc.identifier.otherPURE: 152888985
dc.identifier.otherPURE UUID: 7f23c156-1485-46da-b478-f13464c81e5b
dc.identifier.otherScopus: 105025922400
dc.identifier.otherWOS: 001648384800001
dc.identifier.urihttp://hdl.handle.net/10362/200304
dc.identifier.urlhttps://www.scopus.com/pages/publications/105025922400
dc.identifier.urlhttps://www.webofscience.com/wos/woscc/full-record/WOS:001648384800001
dc.language.isoeng
dc.peerreviewedyes
dc.subjectMicroplastics
dc.subjectPlastic pollution
dc.subjectPolyethylene terephthalate
dc.subjectPolylactic acid
dc.subjectProtein bioaccessibility
dc.subjectSeafood safety
dc.subjectEnvironmental Science (miscellaneous)
dc.subjectSDG 3 - Good Health and Well-being
dc.titleDifferential Effects of the Human Digestive Process on Petroleum- and Bio-Based Microplastics Following an In Vitro Approach to Determine Polymer Integrity and Seafood Digestibilityen
dc.typejournal article
degois.publication.firstPage1
degois.publication.issue4
degois.publication.lastPage16
degois.publication.titleMicroplastics
degois.publication.volume4
dspace.entity.typePublication
rcaap.rightsopenAccess

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