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Activated Carbon/Pectin Composite Enterosorbent for Human Protection from Intoxication with Xenobiotics Pb(II) and Sodium Diclofenac

2022-04-01Artigo científico Acesso aberto
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dc.contributor.authorJandosov, Jakpar
dc.contributor.authorAlavijeh, Mo
dc.contributor.authorSultakhan, Shynggyskhan
dc.contributor.authorBaimenov, Alzhan
dc.contributor.authorBernardo, Maria
dc.contributor.authorSakipova, Zuriyadda
dc.contributor.authorAzat, Seytkhan
dc.contributor.authorLyubchyk, Svitlana
dc.contributor.authorZhylybayeva, Nurzhamal
dc.contributor.authorNaurzbayeva, Gulmira
dc.contributor.authorMansurov, Zulkhair
dc.contributor.authorMikhalovsky, Sergey
dc.contributor.authorBerillo, Dmitriy
dc.contributor.institutionLAQV@REQUIMTE
dc.contributor.institutionDQ - Departamento de Química
dc.contributor.pblMDPI - Multidisciplinary Digital Publishing Institute
dc.date.accessioned2022-08-02T22:24:53Z
dc.date.available2022-08-02T22:24:53Z
dc.date.issued2022-04-01
dc.descriptionFunding Information: Funding: IRN AP09562399 «Biomedical product based on nanoporous active carbon and low-esterified pectin for gastrointestinal sorption in case of intoxication caused by xenobiotics» grant funded by the Committee of Science at the Ministry of Education and Science of the Republic of Kazakhstan. Publisher Copyright: © 2022 by the authors. Licensee MDPI, Basel, Switzerland.
dc.description.abstractThe use of enterosorbents—materials which can be administered orally and eliminate toxic substances from the gastrointestinal tract (GIT) by sorption—offers an attractive complementary protection of humans against acute and chronic poisoning. In this study, we report the results of developing a microgranulated binary biomedical preparation for oral use. It was designed with a core-shell structure based on pectin with low degree of esterification as the core, and nanoporous activated carbon produced from rice husk, AC-RH, as the shell, designated as AC-RH@pectin. The adsorption properties of the synthesized materials were studied in aqueous solutions for the removal of lead (II) nitrate as a representative of toxic polyvalent metals and sodium diclofenac as an example of a medicinal drug. The composite enterosorbent demonstrated high adsorption capacity for both adsorbates studied. Adsorption kinetics of lead and diclofenac adsorption by AC-RH, pectin, and AC-RH@pectin, fitted well a pseudo-second-order model. According to the Langmuir adsorption isotherm model, the best fitted isotherm model, the maximum adsorption capacity, qmax, of AC-RH@pectin for diclofenac and for lead (II) was 130.9 mg/g and 227.8 mg/g, respectively. Although qmax of AC-RH for diclofenac, 537.6 mg/g, and qmax of pectin for lead (II), 245.7 mg/g, were higher, the maximum adsorption capacity of AC-RH for lead (II), 52.7 mg/g, was much lower than that of the composite AC-RH@pectin and the adsorption capacity of pectin for diclofenac was negligible. Therefore, the composite material AC-RH@pectin demonstrated substantial efficiency of removing both species which potentially defines it as a more universal enterosorbent suitable for treating poisoning caused by substances of different chemical nature.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent18
dc.format.extent8092438
dc.identifier.doi10.3390/molecules27072296
dc.identifier.issn1420-3049
dc.identifier.otherPURE: 43514016
dc.identifier.otherPURE UUID: 879d01c9-d433-47c6-9ce1-d35d17859ca6
dc.identifier.otherScopus: 85128097030
dc.identifier.otherPubMed: 35408695
dc.identifier.otherWOS: 000781333000001
dc.identifier.otherPubMedCentral: PMC9000640
dc.identifier.otherORCID: /0000-0002-5823-6636/work/164706181
dc.identifier.urihttp://hdl.handle.net/10362/142795
dc.identifier.urlhttps://www.scopus.com/pages/publications/85128097030
dc.language.isoeng
dc.peerreviewedyes
dc.subjectdiclofenac adsorption
dc.subjectenterosorbent
dc.subjectlead adsorption
dc.subjectpectin
dc.subjectporous carbon
dc.subjectAnalytical Chemistry
dc.subjectChemistry (miscellaneous)
dc.subjectMolecular Medicine
dc.subjectPharmaceutical Science
dc.subjectDrug Discovery
dc.subjectPhysical and Theoretical Chemistry
dc.subjectOrganic Chemistry
dc.titleActivated Carbon/Pectin Composite Enterosorbent for Human Protection from Intoxication with Xenobiotics Pb(II) and Sodium Diclofenacen
dc.typejournal article
degois.publication.issue7
degois.publication.titleMolecules
degois.publication.volume27
dspace.entity.typePublication
rcaap.rightsopenAccess

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