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Molecular Pathways and Mechanisms in the Biogenesis of Influenza A Virus Matrix Protein 2
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| 13.03 MB | Adobe PDF |
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Resumo(s)
"Membrane protein biogenesis is an essential cellular process, ensuring the proper
synthesis, targeting, and insertion of proteins into biological membranes. This thesis
investigates the molecular mechanisms governing membrane protein biogenesis,
with a particular focus on how the Influenza A Virus (IAV) hijacks host cellular
pathways to support viral protein production. The study primarily explores the role of
the Endoplasmic Reticulum Membrane Protein Complex (EMC) in the biogenesis of
the IAV M2 protein, an integral membrane protein that functions as a proton channel
critical for viral replication, budding, and host cell remodeling.(...)"
Descrição
Palavras-chave
Membrane protein biogenesis Endoplasmic Reticulum Membrane Protein Complex (EMC) viral infection