Logo do repositório
 
Publicação

Peripheral Blood Serum NMR Metabolomics Is a Powerful Tool to Discriminate Benign and Malignant Ovarian Tumors

2023-09Artigo científico Acesso aberto
Ver registo simples
dc.contributor.authorNunes, Sofia C.
dc.contributor.authorSousa, Joana
dc.contributor.authorSilva, Fernanda
dc.contributor.authorSilveira, Margarida
dc.contributor.authorGuimarães, António
dc.contributor.authorSerpa, Jacinta
dc.contributor.authorFélix, Ana
dc.contributor.authorGonçalves, Luís G.
dc.contributor.institutionNOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
dc.contributor.institutioniNOVA4Health - pólo NMS
dc.contributor.institutionInstituto de Tecnologia Química e Biológica António Xavier (ITQB)
dc.contributor.pblMDPI - Multidisciplinary Digital Publishing Institute
dc.date.accessioned2023-11-10T22:08:55Z
dc.date.available2023-11-10T22:08:55Z
dc.date.issued2023-09
dc.descriptionFunding Information: The institutions are funded by Fundação para a Ciência e a Tecnologia/Ministério da Ciência, Tecnologia e Ensino Superior (FCT/MCTES, Portugal) through national funds to iNOVA4Health (UIDB/04462/2020 and UIDP/04462/2020), to MOSTMICRO-ITQB (UIDB/04612/2020 and UIDP/04612/2020) and the Associated Laboratory LS4FUTURE (LA/P/0087/2020). The NMR data was acquired at CERMAX, ITQB-NOVA, Oeiras, Portugal with equipment funded by FCT, project AAC 01/SAICT/2016 and at CICS-UBI (Health Sciences Research Centre—University of Beira Interior) with equipment acquired in the scope of the project POVT-0439-FEDER-00001. Luis G. Gonçalves was financed by a FCT contract according to DL57/2016, [SFRH/BPD/111100/2015]. Publisher Copyright: © 2023 by the authors.
dc.description.abstractOvarian cancer is the major cause of death from gynecological cancer and the third most common gynecological malignancy worldwide. Despite a slight improvement in the overall survival of ovarian carcinoma patients in recent decades, the cure rate has not improved. This is mainly due to late diagnosis and resistance to therapy. It is therefore urgent to develop effective methods for early detection and prognosis. We hypothesized that, besides being able to distinguish serum samples of patients with ovarian cancer from those of patients with benign ovarian tumors, 1H-NMR metabolomics analysis might be able to predict the malignant potential of tumors. For this, serum 1H-NMR metabolomics analyses were performed, including patients with malignant, benign and borderline ovarian tumors. The serum metabolic profiles were analyzed by multivariate statistical analysis, including principal component analysis (PCA) and orthogonal partial least squares discriminant analysis (OPLS-DA) methods. A metabolic profile associated with ovarian malignant tumors was defined, in which lactate, 3-hydroxybutyrate and acetone were increased and acetate, histidine, valine and methanol were decreased. Our data support the use of 1H-NMR metabolomics analysis as a screening method for ovarian cancer detection and might be useful for predicting the malignant potential of borderline tumors.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent1879767
dc.identifier.doi10.3390/metabo13090989
dc.identifier.issn2218-1989
dc.identifier.otherPURE: 73149524
dc.identifier.otherPURE UUID: 3a530ae2-bb0f-431e-9b4a-99dcc616b6cd
dc.identifier.otherScopus: 85172184495
dc.identifier.otherORCID: /0000-0001-5683-3552/work/151405761
dc.identifier.otherORCID: /0000-0002-2653-2262/work/151417765
dc.identifier.otherORCID: /0000-0002-1548-5907/work/151423013
dc.identifier.urihttp://hdl.handle.net/10362/159814
dc.identifier.urlhttps://www.scopus.com/pages/publications/85172184495
dc.language.isoeng
dc.peerreviewedyes
dc.subjectbenign ovarian tumors
dc.subjectbiomarkers
dc.subjectborderline ovarian tumors
dc.subjectcancer progression
dc.subjectmalignant ovarian tumors
dc.subjectNMR metabolomics
dc.subjectovarian cancer
dc.subjectserum
dc.subjectEndocrinology, Diabetes and Metabolism
dc.subjectBiochemistry
dc.subjectMolecular Biology
dc.subjectSDG 3 - Good Health and Well-being
dc.titlePeripheral Blood Serum NMR Metabolomics Is a Powerful Tool to Discriminate Benign and Malignant Ovarian Tumorsen
dc.typejournal article
degois.publication.issue9
degois.publication.titleMetabolites
degois.publication.volume13
dspace.entity.typePublication
rcaap.rightsopenAccess

Ficheiros

Principais
A mostrar 1 - 1 de 1
Miniatura
Nome:
metabolites_13_00989.pdf
Tamanho:
1.79 MB
Formato:
Adobe Portable Document Format
Ver/Abrir

Coleções

Home collection (ITQB)