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Histamina e seus recetores

2023Recensão Acesso aberto
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dc.contributor.authorCouto, Sofia
dc.contributor.authorMartins, Catarina
dc.contributor.authorBorrego, Luís Miguel
dc.contributor.institutionNOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
dc.contributor.institutionComprehensive Health Research Centre (CHRC) - pólo NMS
dc.contributor.pblSociedade Portuguesa de Alergologia e Imunologia Clinica
dc.date.accessioned2023-04-19T22:23:08Z
dc.date.available2023-04-19T22:23:08Z
dc.date.issued2023
dc.description.abstractHistamine is one of the main mediators involved in immune homeostasis, presenting a myriad of functions. Four histamine receptors (HR) are currently known, being HR1 the best characterized and recognized for its association with allergic diseases pathophysiology. HR2 is known for its involvement in gastric pathology, HR3 for its neuromodulatory role and, more recently, HR4, considered to be involved also in allergic pathology, as well as in autoimmunity and cancer. There are several drugs available on the market that block H1 receptors, as well as H2 receptors. Recently, anti-H3 drugs have been described, with therapeutic potential in neurological diseases. There are several molecules in study, blocking HR4, in monotherapy or in combination with blocking HR1, with therapeutic potential in allergic disease, in some neoplasms and autoimmune pathologies.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent10
dc.format.extent244867
dc.identifier.doi10.32932/rpia.2023.03.099
dc.identifier.issn0871-9721
dc.identifier.otherPURE: 58128542
dc.identifier.otherPURE UUID: 6987d0a6-305a-4db1-8e9a-ec6e6878a4dc
dc.identifier.otherScopus: 85151544292
dc.identifier.urihttp://hdl.handle.net/10362/151936
dc.identifier.urlhttps://www.scopus.com/pages/publications/85151544292
dc.language.isopor
dc.peerreviewedyes
dc.subjectallergy
dc.subjectAntihistamines
dc.subjectH1 receptors antagonists
dc.subjectH2-receptor antagonists
dc.subjectH3-receptor antagonists
dc.subjectH4 receptors antagonists
dc.subjectImmunology and Allergy
dc.subjectImmunology
dc.subjectSDG 3 - Good Health and Well-being
dc.titleHistamina e seus recetorespt
dc.title.alternativeHistamine and its receptorsFrom physiology to pathologyen
dc.title.subtitleDa fisiologia à patologiapt
dc.typereview
degois.publication.firstPage13
degois.publication.issue1
degois.publication.lastPage22
degois.publication.titleRevista Portuguesa de Imunoalergologia
degois.publication.volume31
dspace.entity.typePublication
rcaap.rightsopenAccess

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