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Characteristic Immune Dynamics in COVID-19 Patients with Cardiac Dysfunction

2022-03-28Artigo científico Acesso aberto
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dc.contributor.authorGonzalez, Filipe André
dc.contributor.authorÂngelo-Dias, Miguel
dc.contributor.authorMartins, Catarina
dc.contributor.authorGomes, Rui
dc.contributor.authorBacariza, Jacobo
dc.contributor.authorFernandes, Antero
dc.contributor.authorBorrego, Luís Miguel
dc.contributor.institutionNOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
dc.contributor.institutionCentro de Estudos de Doenças Crónicas (CEDOC)
dc.contributor.pblMDPI - Multidisciplinary Digital Publishing Institute
dc.date.accessioned2022-04-08T22:36:07Z
dc.date.available2022-04-08T22:36:07Z
dc.date.issued2022-03-28
dc.descriptionFunding Information: Type of funding sources: Foundation—015_595935779—Foundation for Science and Technology (FCT), in collaboration with the Agency for Clinical Research and Biomedical Innovation (AICIB) opened special funding, “RESEARCH 4 COVID-19”, to R&D projects and initiatives that respond to the needs of the National Health Service (SNS) as a response to this and future pandemics in a very short time Horizon. Project: “Early recognition of cardiac injury associated with COVID-19 and clinical outcomes”.
dc.description.abstractBackground: We aimed to explore immune parameters in COVID-19 patients admitted to the intensive care unit (ICU) to identify distinctive features in patients with cardiac injury. Methods: A total of 30 COVID-19 patients >18 years admitted to the ICU were studied on days D1, D3 and D7 after admission. Cardiac function was assessed using speckle-tracking echocardiography (STE). Peripheral blood immunophenotyping, cardiac (pro-BNP; troponin) and inflammatory biomarkers were simultaneously evaluated. Results: Cardiac dysfunction (DYS) was detected by STE in 73% of patients: 40% left ventricle (LV) systolic dysfunction, 60% LV diastolic dysfunction, 37% right ventricle systolic dysfunction. High-sensitivity cardiac troponin (hs-cTn) was detectable in 43.3% of the patients with a median value of 13.00 ng/L. There were no significant differences between DYS and nDYS patients regarding mortality, organ dysfunction, cardiac (including hs-cTn) or inflammatory biomarkers. Patients with DYS showed persistently lower lymphocyte counts (median 896 [661–1837] cells/µL vs. 2141 [924–3306] cells/µL, p = 0.058), activated CD3 (median 85 [66–170] cells/µL vs. 186 [142–259] cells/µL, p = 0.047) and CD4 T cells (median 33 [28–40] cells/µL vs. 63 [48–79] cells/µL, p = 0.005), and higher effector memory T cells (TEM) at baseline (CD4%: 10.9 [6.4–19.2] vs. 5.9 [4.2–12.8], p = 0.025; CD8%: 15.7 [7.9–22.8] vs. 8.1 [7.7–13.7], p = 0.035; CD8 counts: 40 cells/µL [17–61] vs. 10 cells/µL [7–17], p = 0.011) than patients without cardiac dysfunction. Conclusion: Our study suggests an association between the immunological trait and cardiac dysfunction in severe COVID-19 patients.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent890537
dc.identifier.doi10.3390/jcm11071880
dc.identifier.issn2077-0383
dc.identifier.otherPURE: 43040553
dc.identifier.otherPURE UUID: 8e0b7342-d455-427e-8175-d4a18713d3ad
dc.identifier.otherScopus: 85127028056
dc.identifier.otherORCID: /0000-0003-4708-438X/work/111177968
dc.identifier.otherORCID: /0000-0003-0353-0421/work/111178098
dc.identifier.otherPubMed: 35407485
dc.identifier.otherWOS: 000781092000001
dc.identifier.otherORCID: /0000-0001-9933-4075/work/206216923
dc.identifier.urihttp://hdl.handle.net/10362/136121
dc.identifier.urlhttps://www.scopus.com/pages/publications/85127028056
dc.language.isoeng
dc.peerreviewedyes
dc.subjectCOVID-19
dc.subjectdiastolic dysfunction
dc.subjectflow cytometry
dc.subjectspeckle-tracking echocardiography
dc.subjectGeneral Medicine
dc.titleCharacteristic Immune Dynamics in COVID-19 Patients with Cardiac Dysfunctionen
dc.typejournal article
degois.publication.issue7
degois.publication.titleJournal of Clinical Medicine
degois.publication.volume11
dspace.entity.typePublication
rcaap.rightsopenAccess

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