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Immunomodulatory and antioxidant effects of functional aquafeeds biofortified with whole Laminaria digitata in juvenile gilthead seabream (Sparus aurata)

2024-01-30Artigo científico Acesso aberto
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dc.contributor.authorMarmelo, Isa
dc.contributor.authorDias, Marta
dc.contributor.authorGrade, Ana
dc.contributor.authorPousão-Ferreira, Pedro
dc.contributor.authorDiniz, Mário Sousa
dc.contributor.authorMarques, António
dc.contributor.authorMaulvault, Ana Luísa
dc.contributor.institutionUCIBIO - Applied Molecular Biosciences Unit
dc.contributor.institutionFaculdade de Ciências e Tecnologia (FCT)
dc.contributor.pblFrontiers Media
dc.date.accessioned2025-02-25T22:23:19Z
dc.date.available2025-02-25T22:23:19Z
dc.date.issued2024-01-30
dc.descriptionFunding Information: The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This work was supported by Fundação Portuguesa para a Ciência e Tecnologia (FCT I.P.), under the framework of the project Aqua-CLIMADAPT (PTDC/CTA-AMB/0592/2021, https://doi.org/10.54499/PTDC/CTA-AMB/0592/2021) and the “Applied Molecular Biosciences Unit” (UCIBIO) which is financed by national funds from FCT/MCTES (UIDB/04378/2020), the project LA/P/0140/2020 of the Associate Laboratory Institute for Health and Bioeconomy—i4HB. IM also acknowledges FCT I.P. for the PhD grant (2020.04413.BD). Publisher Copyright: Copyright © 2024 Marmelo, Dias, Grade, Pousão-Ferreira, Diniz, Marques and Maulvault.
dc.description.abstractThe increasing demand for healthy aquatic products has contributed to the rapid growth of aquaculture. Despite the many progresses, over the years, in aquaculture production, animal welfare and reduction of the stress induced by captivity remain a challenge in this sector, and overcoming it is fundamental to improve animal growth performance and resilience to environmental threats (e.g., disease outbreaks and/or climate change impacts). To address this challenge, aquafeeds biofortified with natural ingredients with functional properties, such as macroalgae, have emerged as a promising strategy to enhance fish immunity. The present study aimed at evaluating the potential of Laminaria digitata to improve juvenile gilthead seabream (Sparus aurata) physiological status and resilience, through the modulation of immunomodulatory and antioxidant responses. To explore this hypothesis, four independent treatments were carried out in which fish were fed with different experimental aquafeeds: control feed and biofortified feeds with 1.5%, 3% and 6% of whole L. digitata (incorporated as a dried and powdered ingredient). Fish (n=9) were collected from each treatment upon 30 and 60 days of biofortification in order to assess animal growth and condition indexes, haematological parameters, innate humoral parameters (antiprotease (AP) activity, peroxidase (POD) activity and immunoglobulin M (IgM)) and oxidative stress biomarkers (lipid peroxidation (LPO), catalase (CAT) activity, glutathione S-transferase (GST) activity, superoxide dismutase (SOD) activity and total antioxidant capacity (T-AOC)). Significant differences (α = 0.05) between treatments in biomarker responses were tested through a nested-design ANOVA, followed by Tukey HSD multiple comparisons. Pearson correlations between the different endpoints were also explored. Results indicate that a dietary inclusion of 1.5% L. digitata is the most effective biofortification dose, significantly improving antioxidant responses of S. aurata, by increasing levels of CAT, GST and T-AOC, along with the reduction in LPO levels. Additionally, the inclusion of 1.5% L. digitata enhances immunity by increasing the levels of IgM and POD, while maintaining the growth performance and condition indices of the fish. These findings underscore the potential utilization of L. digitata as a functional feed ingredient in aquaculture with relevant immune and antioxidant attributes.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent16
dc.format.extent852273
dc.identifier.doi10.3389/fmars.2024.1325244
dc.identifier.issn2296-7745
dc.identifier.otherPURE: 106509293
dc.identifier.otherPURE UUID: 32523617-2db0-4ca2-8008-c8ee9ea9e743
dc.identifier.otherScopus: 85184698870
dc.identifier.urihttp://hdl.handle.net/10362/179816
dc.identifier.urlhttps://www.scopus.com/pages/publications/85184698870
dc.language.isoeng
dc.peerreviewedyes
dc.relationinfo:eu-repo/grantAgreement/FCT/Concurso de Projetos IC&DT em Todos os Domínios Científicos/PTDC%2FCTA-AMB%2F0592%2F2021/PT
dc.relationinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04378%2F2020/PT
dc.relationApplied Molecular Biosciences Unit
dc.relationinfo:eu-repo/grantAgreement/FCT//2020.04413.BD/PT
dc.subjectanimal welfare
dc.subjectantioxidant responses
dc.subjectaquaculture
dc.subjectfunctional feeds
dc.subjectimmune responses
dc.subjectseaweeds
dc.subjectOceanography
dc.subjectGlobal and Planetary Change
dc.subjectAquatic Science
dc.subjectWater Science and Technology
dc.subjectEnvironmental Science (miscellaneous)
dc.subjectOcean Engineering
dc.subjectSDG 13 - Climate Action
dc.titleImmunomodulatory and antioxidant effects of functional aquafeeds biofortified with whole Laminaria digitata in juvenile gilthead seabream (Sparus aurata)en
dc.typejournal article
degois.publication.firstPage1
degois.publication.lastPage16
degois.publication.titleFrontiers in Marine Science
degois.publication.volume11
dspace.entity.typePublication
oaire.awardNumberPTDC/CTA-AMB/0592/2021
oaire.awardNumberUIDB/04378/2020
oaire.awardNumberLA/P/0140/2020
oaire.awardNumber2020.04413.BD
oaire.awardTitleApplied Molecular Biosciences Unit
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/Concurso de Projetos IC&DT em Todos os Domínios Científicos/PTDC%2FCTA-AMB%2F0592%2F2021/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04378%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/Concurso para Atribuição do Estatuto e Financiamento de Laboratórios Associados (LA)/LA%2FP%2F0140%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//2020.04413.BD/PT
oaire.fundingStreamConcurso de Projetos IC&DT em Todos os Domínios Científicos
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamConcurso para Atribuição do Estatuto e Financiamento de Laboratórios Associados (LA)
project.funder.identifierhttp://doi.org/10.13039/501100001871
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project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccess
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