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How Can Deep Eutectic Systems Promote Greener Processes in Medicinal Chemistry and Drug Discovery?

2024-02Recensão Acesso aberto
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dc.contributor.authorDomingues, Luis
dc.contributor.authorDuarte, Ana Rita C.
dc.contributor.authorJesus, Ana Rita
dc.contributor.institutionDQ - Departamento de Química
dc.contributor.institutionLAQV@REQUIMTE
dc.contributor.pblMolecular Diversity Preservation International (MDPI)
dc.date.accessioned2025-02-17T21:14:42Z
dc.date.available2025-02-17T21:14:42Z
dc.date.issued2024-02
dc.descriptionFunding Information: This research was funded by the European Research Council (ERC), under the European Union\u2019s Horizon 2020 Research and Innovation Programme, under grant agreement No CryoDES ERC-2022-POC2 101101088. Publisher Copyright: © 2024 by the authors.
dc.description.abstractChemists in the medicinal chemistry field are constantly searching for alternatives towards more sustainable and eco-friendly processes for the design and synthesis of drug candidates. The pharmaceutical industry is one of the most polluting industries, having a high E-factor, which is driving the adoption of more sustainable processes not only for new drug candidates, but also in the production of well-established active pharmaceutical ingredients. Deep eutectic systems (DESs) have emerged as a greener alternative to ionic liquids, and their potential to substitute traditional organic solvents in drug discovery has raised interest among scientists. With the use of DESs as alternative solvents, the processes become more attractive in terms of eco-friendliness and recyclability. Furthermore, they might be more effective through making the process simpler, faster, and with maximum efficiency. This review will be focused on the role and application of deep eutectic systems in drug discovery, using biocatalytic processes and traditional organic chemical reactions, as new environmentally benign alternative solvents. Furthermore, herein we also show that DESs, if used in the pharmaceutical industry, may have a significant effect on lowering production costs and decreasing the impact of this industry on the quality of the environment.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent3722215
dc.identifier.doi10.3390/ph17020221
dc.identifier.issn1424-8247
dc.identifier.otherPURE: 106515343
dc.identifier.otherPURE UUID: 99808882-8947-4712-9d9d-1c798e27bc08
dc.identifier.otherScopus: 85187236122
dc.identifier.urihttp://hdl.handle.net/10362/179197
dc.identifier.urlhttps://www.scopus.com/pages/publications/85187236122
dc.language.isoeng
dc.peerreviewedyes
dc.relationinfo:eu-repo/grantAgreement/EC/H2020/725034/EU
dc.relationWhen solids become liquids: natural deep eutectic solvents for chemical process engineering
dc.relationAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
dc.subjectdeep eutectic systems
dc.subjectdrug discovery
dc.subjectgreen chemistry
dc.subjectpharmaceuticals
dc.subjectsynthesis
dc.subjectMolecular Medicine
dc.subjectPharmaceutical Science
dc.subjectDrug Discovery
dc.titleHow Can Deep Eutectic Systems Promote Greener Processes in Medicinal Chemistry and Drug Discovery?en
dc.typereview
degois.publication.issue2
degois.publication.titlePharmaceuticals
degois.publication.volume17
dspace.entity.typePublication
oaire.awardNumber725034
oaire.awardNumberUID/QUI/50006/2019
oaire.awardTitleWhen solids become liquids: natural deep eutectic solvents for chemical process engineering
oaire.awardTitleAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
oaire.awardURIinfo:eu-repo/grantAgreement/EC/H2020/725034/EU
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FQUI%2F50006%2F2019/PT
oaire.fundingStreamH2020
oaire.fundingStream6817 - DCRRNI ID
project.funder.identifierhttp://doi.org/10.13039/501100008530
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameEuropean Commission
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccess
relation.isProjectOfPublicationc3c7a420-917d-40d1-8eee-26b6ad145ebd
relation.isProjectOfPublicationef56aec5-d0e7-4c5e-ac5e-3e3141ae67f2
relation.isProjectOfPublication.latestForDiscoveryef56aec5-d0e7-4c5e-ac5e-3e3141ae67f2

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