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Pharmacological modulation of ventral tegmental area neurons elicits changes in trigeminovascular sensory processing and is accompanied by glycemic changes

2022-11Artigo científico Acesso aberto
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dc.contributor.authorMartins-Oliveira, Margarida
dc.contributor.authorAkerman, Simon
dc.contributor.authorHolland, Philip R.
dc.contributor.authorTavares, Isaura
dc.contributor.authorGoadsby, Peter J.
dc.contributor.institutionNOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
dc.contributor.pblSAGE Publications
dc.date.accessioned2022-10-28T22:10:58Z
dc.date.available2022-10-28T22:10:58Z
dc.date.issued2022-11
dc.descriptionFunding Information: The authors disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: Margarida Martins-Oliveira is grateful to the Portuguese Fundação para a Ciência e Tecnologia (FCT) for its support with an individual PhD grant (SFRH/BD/77127/2011). The conduct of the research was financially supported by the EUROHEADPAIN European Union FP7 (PJG & PRH: 602633), the Wellcome Trust (PJG: 104033) and the Medical Research Council (PRH: MR/P006264/1). Publisher Copyright: © International Headache Society 2022.
dc.description.abstractBackground: Imaging migraine premonitory studies show increased midbrain activation consistent with the ventral tegmental area, an area involved in pain modulation and hedonic feeding. We investigated ventral tegmental area pharmacological modulation effects on trigeminovascular processing and consequent glycemic levels, which could be involved in appetite changes in susceptible migraine patients. Methods: Serotonin and pituitary adenylate cyclase-activating polypeptide receptors immunohistochemistry was performed in ventral tegmental area parabrachial pigmented nucleus of male Sprague Dawley rats. In vivo trigeminocervical complex neuronal responses to dura mater nociceptive electrical stimulation, and facial mechanical stimulation of the ophthalmic dermatome were recorded. Changes in trigeminocervical complex responses following ventral tegmental area parabrachial pigmented nucleus microinjection of glutamate, bicuculline, naratriptan, pituitary adenylate cyclase-activating polypeptide-38 and quinpirole were measured, and blood glucose levels assessed pre- and post-microinjection. Results: Glutamatergic stimulation of ventral tegmental area parabrachial pigmented nucleus neurons reduced nociceptive and spontaneous trigeminocervical complex neuronal firing. Naratriptan, pituitary adenylate cyclase-activating polypeptide-38 and quinpirole inhibited trigeminovascular spontaneous activity, and trigeminocervical complex neuronal responses to dural-evoked electrical and mechanical noxious stimulation. Trigeminovascular sensory processing through modulation of the ventral tegmental area parabrachial pigmented nucleus resulted in reduced circulating glucose levels. Conclusion: Pharmacological modulation of ventral tegmental area parabrachial pigmented nucleus neurons elicits changes in trigeminovascular sensory processing. The interplay between ventral tegmental area parabrachial pigmented nucleus activity and the sensory processing by the trigeminovascular system may be relevant to understand associated sensory and homeostatic symptoms in susceptible migraine patients.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent1382694
dc.identifier.doi10.1177/03331024221110111
dc.identifier.issn0333-1024
dc.identifier.otherPURE: 47357928
dc.identifier.otherPURE UUID: d13d8b18-309c-4c7d-80da-eaac3d5ef573
dc.identifier.otherScopus: 85140122898
dc.identifier.otherWOS: 000869936800001
dc.identifier.urihttp://hdl.handle.net/10362/145104
dc.identifier.urlhttps://www.scopus.com/pages/publications/85140122898
dc.language.isoeng
dc.peerreviewedyes
dc.subjectblood glucose
dc.subjectmigraine
dc.subjectnaratriptan
dc.subjectnociception
dc.subjectPACAP
dc.subjectVentral tegmental area
dc.subjectClinical Neurology
dc.titlePharmacological modulation of ventral tegmental area neurons elicits changes in trigeminovascular sensory processing and is accompanied by glycemic changesen
dc.title.subtitleImplications for migraineen
dc.typejournal article
degois.publication.firstPage1359
degois.publication.issue13
degois.publication.lastPage1374
degois.publication.titleCephalalgia
degois.publication.volume42
dspace.entity.typePublication
rcaap.rightsopenAccess

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