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Endothelial dysfunction triggers acute respiratory distress syndrome in patients with sepsis

2023-06-02Recensão Acesso aberto
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dc.contributor.authorCusack, Rachael
dc.contributor.authorBos, Lieuwe D.
dc.contributor.authorPovoa, Pedro
dc.contributor.authorPovoa, Pedro
dc.contributor.authorMartin-Loeches, Ignacio
dc.contributor.institutionNOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
dc.contributor.institutionComprehensive Health Research Centre (CHRC) - pólo NMS
dc.contributor.pblFrontiers Media
dc.date.accessioned2023-06-28T22:18:36Z
dc.date.available2023-06-28T22:18:36Z
dc.date.issued2023-06-02
dc.description.abstractAcute respiratory distress syndrome (ARDS) is a severe organ failure occurring mainly in critically ill patients as a result of different types of insults such as sepsis, trauma or aspiration. Sepsis is the main cause of ARDS, and it contributes to a high mortality and resources consumption both in hospital setting and in the community. ARDS develops mainly an acute respiratory failure with severe and often refractory hypoxemia. ARDS also has long term implications and sequelae. Endothelial damage plays an important role in the pathogenesis of ARDS. Understanding the mechanisms of ARDS presents opportunities for novel diagnostic and therapeutic targets. Biochemical signals can be used in concert to identify and classify patients into ARDS phenotypes allowing earlier effective treatment with personalised therapies. This is a narrative review where we aimed to flesh out the pathogenetic mechanisms and heterogeneity of ARDS. We examine the links between endothelium damage and its contribution to organ failure. We have also investigated future strategies for treatment with a special emphasis in endothelial damage.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent1352293
dc.identifier.doi10.3389/fmed.2023.1203827
dc.identifier.issn2296-858X
dc.identifier.otherPURE: 64790489
dc.identifier.otherPURE UUID: 84caec84-7a90-4677-ace9-20c7e7a8874b
dc.identifier.otherScopus: 85162123325
dc.identifier.urihttp://hdl.handle.net/10362/154564
dc.identifier.urlhttps://www.scopus.com/pages/publications/85162123325
dc.language.isoeng
dc.peerreviewedyes
dc.subjectacute respiratory distress syndrome
dc.subjectendothelial dysfunction
dc.subjectintensive care
dc.subjectmicrocirculation
dc.subjectsepsis
dc.subjectsub-phenotypes
dc.subjectGeneral Medicine
dc.titleEndothelial dysfunction triggers acute respiratory distress syndrome in patients with sepsisen
dc.title.subtitlea narrative reviewen
dc.typereview
degois.publication.titleFrontiers in medicine
degois.publication.volume10
dspace.entity.typePublication
person.familyNamePovoa
person.givenNamePedro
person.identifier.ciencia-id0C16-5CF9-9238
person.identifier.orcid0000-0002-7069-7304
person.identifier.scopus-author-id6602772147
rcaap.rightsopenAccess
relation.isAuthorOfPublication04ec38ba-be1e-46e5-8007-0e65a557d0f4
relation.isAuthorOfPublication.latestForDiscovery04ec38ba-be1e-46e5-8007-0e65a557d0f4

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