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Proteomic Profile of Endometrial Cancer

2024-08Recensão Acesso aberto
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dc.contributor.authorSerambeque, Beatriz
dc.contributor.authorMestre, Catarina
dc.contributor.authorHundarova, Kristina
dc.contributor.authorOliveiros, Bárbara
dc.contributor.authorGomes, Ana Rita
dc.contributor.authorTeixo, Ricardo
dc.contributor.authorCarvalho, Ana Sofia
dc.contributor.authorBotelho, Maria Filomena
dc.contributor.authorMatthiesen, Rune
dc.contributor.authorMatthiesen, Rune
dc.contributor.authorCarvalho, Maria João
dc.contributor.authorMarto, Carlos M
dc.contributor.authorLaranjo, Mafalda
dc.contributor.institutionNOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
dc.contributor.institutioniNOVA4Health - pólo NMS
dc.contributor.pblMDPI - Multidisciplinary Digital Publishing Institute
dc.date.accessioned2024-09-30T22:28:07Z
dc.date.available2024-09-30T22:28:07Z
dc.date.issued2024-08
dc.descriptionPublisher Copyright: © 2024 by the authors.
dc.description.abstractProteomics can be a robust tool in protein identification and regulation, allowing the discovery of potential biomarkers. In clinical practice, the management of endometrial cancer can be challenging. Thus, identifying promising markers could be beneficial, helping both in diagnosis and prognostic stratification, even predicting the response to therapy. Therefore, this manuscript systematically reviews the existing evidence of the proteomic profile of human endometrial cancer. The literature search was conducted via Medline (through PubMed) and the Web of Science. The inclusion criteria were clinical, in vitro, and in vivo original studies reporting proteomic analysis using all types of samples to map the human endometrial cancer proteome. A total of 55 publications were included in this review. Most of the articles carried out a proteomic analysis on endometrial tissue, serum and plasma samples, which enabled the identification of several potential diagnostic and prognostic biomarkers. In addition, eight articles were analyzed regarding the identified proteins, where three studies showed a strong correlation, sharing forty-five proteins. This analysis also allowed the identification of the 10 most frequently reported proteins in these studies: EGFR, PGRMC1, CSE1L, MYDGF, STMN1, CASP3 ANXA2, YBX1, ANXA1, and MYH11. Proteomics-based approaches pointed out potential diagnostic and prognostic candidates for endometrial cancer. However, there is a lack of studies exploring novel therapeutic targets.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent1440797
dc.identifier.doi10.3390/biology13080584
dc.identifier.issn2079-7737
dc.identifier.otherPURE: 99109219
dc.identifier.otherPURE UUID: 29df05d0-12ec-49e8-bd09-7ef4920f0592
dc.identifier.otherScopus: 85202612094
dc.identifier.otherPubMed: 39194522
dc.identifier.urihttp://hdl.handle.net/10362/172697
dc.identifier.urlhttps://www.scopus.com/pages/publications/85202612094
dc.language.isoeng
dc.peerreviewedyes
dc.subjectbiomarkers
dc.subjectdiagnosis
dc.subjectendometrial cancer
dc.subjectprognosis
dc.subjectproteomics
dc.subjecttherapeutics
dc.subjectGeneral Biochemistry,Genetics and Molecular Biology
dc.subjectGeneral Immunology and Microbiology
dc.subjectGeneral Agricultural and Biological Sciences
dc.subjectSDG 3 - Good Health and Well-being
dc.titleProteomic Profile of Endometrial Canceren
dc.title.subtitleA Scoping Reviewen
dc.typereview
degois.publication.issue8
degois.publication.titleBiology
degois.publication.volume13
dspace.entity.typePublication
person.familyNameMatthiesen
person.givenNameRune
person.identifier1319342
person.identifier.ciencia-idBB1A-A606-EE77
person.identifier.orcid0000-0002-6353-2616
person.identifier.scopus-author-id9741897800
rcaap.rightsopenAccess
relation.isAuthorOfPublication67181d3c-b83e-4151-9a74-0ea14aeb7f05
relation.isAuthorOfPublication.latestForDiscovery67181d3c-b83e-4151-9a74-0ea14aeb7f05

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