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Therapeutic deep eutectic systems towards the treatment of tuberculosis and colorectal cancer

2021-11-20Recensão Acesso aberto
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dc.contributor.authorOliveira, Filipe
dc.contributor.authorSantos, Filipa
dc.contributor.authorDuarte, Ana Rita C.
dc.contributor.institutionDQ - Departamento de Química
dc.contributor.institutionLAQV@REQUIMTE
dc.contributor.pblMDPI - Multidisciplinary Digital Publishing Institute
dc.date.accessioned2022-07-27T22:26:21Z
dc.date.available2022-07-27T22:26:21Z
dc.date.issued2021-11-20
dc.descriptionERC-2016-CoG 725034 POCI-01-0145-FEDER 007265
dc.description.abstractWhat if a new technology based on therapeutic deep eutectic systems would disrupt the current treatment of major economic and socially burdensome diseases? The classical definition of eutectic systems is that they are the combination of two or more compounds that interact via hydrogen bonds, from which results a melting temperature depression in comparison with that of its individual components. Therapeutic deep eutectic systems are defined as eutectic systems in which at least one of the individual components is an active pharmaceutical ingredient, or a eutectic system in which the active pharmaceutical ingredient is dissolved. Current literature reports on tuberculosis have been mostly based on the most common anti-tuberculosis drugs prescribed. Using eutectic systems based on naturally occurring molecules known for their anti-microbial activity may also present a promising therapeutic strategy able to cope with the prevalence of Mycobacterium tuberculosis and prevent the appearance of multidrug resistance strains. With regards to colorectal cancer, literature has been unravelling combinations of terpenes with anti-inflammatory drugs that are selectively cytotoxic towards colorectal cancer cells and do not compromise the viability of normal intestinal cells. This technology could contribute to preventing tumor growth and metastasis while providing a patient compliance therapeutics, which will be crucial to the success of overcoming the challenges presented by cancers.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent726610
dc.identifier.doi10.3390/molecules26227022
dc.identifier.issn1420-3049
dc.identifier.otherPURE: 45641693
dc.identifier.otherPURE UUID: bc38c236-2b68-49e0-b187-75c39477275e
dc.identifier.otherScopus: 85119905993
dc.identifier.otherPubMed: 34834115
dc.identifier.otherPubMedCentral: PMC8618747
dc.identifier.otherWOS: 000725139300001
dc.identifier.urihttp://hdl.handle.net/10362/142523
dc.identifier.urlhttps://www.scopus.com/pages/publications/85119905993
dc.language.isoeng
dc.peerreviewedyes
dc.relationinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F50006%2F2020/PT
dc.relationAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
dc.relationTherapeutic deep eutectic systems as promising selective therapeutic agents in the anticancer battle
dc.subjectActive pharmaceutical ingredient
dc.subjectColorectal cancer
dc.subjectDrug delivery
dc.subjectTherapeutic deep eutectic systems
dc.subjectTuberculosis
dc.subjectAnalytical Chemistry
dc.subjectChemistry (miscellaneous)
dc.subjectMolecular Medicine
dc.subjectPharmaceutical Science
dc.subjectDrug Discovery
dc.subjectPhysical and Theoretical Chemistry
dc.subjectOrganic Chemistry
dc.subjectSDG 3 - Good Health and Well-being
dc.titleTherapeutic deep eutectic systems towards the treatment of tuberculosis and colorectal canceren
dc.title.subtitleOpportunities and challengesen
dc.typereview
degois.publication.issue22
degois.publication.titleMolecules
degois.publication.volume26
dspace.entity.typePublication
oaire.awardNumberUIDB/50006/2020
oaire.awardNumber2021.07780.BD
oaire.awardTitleAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
oaire.awardTitleTherapeutic deep eutectic systems as promising selective therapeutic agents in the anticancer battle
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F50006%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//2021.07780.BD/PT
oaire.fundingStream6817 - DCRRNI ID
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccess
relation.isProjectOfPublicationadc84c24-ba1d-4bcd-b753-2128ce9a5faa
relation.isProjectOfPublication41ba8507-b30f-4283-8dec-c8b6b8a24bb5
relation.isProjectOfPublication.latestForDiscoveryadc84c24-ba1d-4bcd-b753-2128ce9a5faa

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