Logo do repositório
 
Publicação

Association between mir-146a and tumor necrosis factor alpha (Tnf-α) in stable coronary artery disease

2021-06Artigo científico Acesso aberto
Ver registo simples
dc.contributor.authorPereira-Da-silva, Tiago
dc.contributor.authorPereira-da-Silva, Tiago
dc.contributor.authorNapoleão, Patrícia
dc.contributor.authorCosta, Marina C.
dc.contributor.authorGabriel, André F.
dc.contributor.authorSelas, Mafalda
dc.contributor.authorSilva, Filipa
dc.contributor.authorEnguita, Francisco J.
dc.contributor.authorCruz Ferreira, Rui
dc.contributor.authorMota Carmo, Miguel
dc.contributor.authorMota Carmo, M
dc.contributor.institutionNOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
dc.contributor.institutionCentro de Estudos de Doenças Crónicas (CEDOC)
dc.contributor.pblMDPI - Multidisciplinary Digital Publishing Institute
dc.date.accessioned2021-07-05T22:18:26Z
dc.date.available2021-07-05T22:18:26Z
dc.date.issued2021-06
dc.description.abstractBackground and Objectives: Tumor necrosis factor alpha (TNF-α) is proatherogenic and associated with the risk of acute ischemic events, although the mechanisms that regulate TNF-α expression in stable coronary artery disease (SCAD) are not fully understood. We investigated whether metabolic, inflammatory, and epigenetic (microRNA (miRNA)) markers are associated with TNF-α expression in SCAD. Materials and Methods: Patients with SCAD were prospectively recruited and their metabolic and inflammatory profiles were assessed. TNF-α levels were assessed using an enzyme-linked immunosorbent assay. The relative expression of six circulating miRNAs associated with the regulation of inflammation and/or atherosclerosis was determined. Results: Of the 24 included patients with the mean age of 65 (9) years, 88% were male, and 54% were diabetic. The TNF-α levels were (median (interquartile range)) 1.0 (0.7–1.1) pg/mL. The percentage of glycosylated hemoglobin (r = 0.418, p = 0.042), serum triglyceride levels (r = 0.429, p = 0.037), and C-reactive protein levels (r = 0.407, p = 0.048) were positively correlated with TNF-α levels. Of the candidate miRNAs, miR-146a expression levels were negatively correlated with TNF-α levels (as indicated by r = 0.500, p = 0.035 for correlation between delta cycle threshold (∆Ct) miR-146a and TNF-α levels). In multivariate analysis, serum triglyceride levels and miR-146a expression levels were independently associated with TNF-α levels. miR-146 expression levels were not associated with metabolic or other inflammatory parameters and were negatively correlated with the number of coronary vessels with obstructive disease (as indicated by r = 0.556, p = 0.017 for correlation between ∆Ct miR-146a and number of diseased vessels). Conclusions: miR-146a expression levels were negatively correlated with TNF-α levels in patients with SCAD, irrespective of other metabolic or inflammatory markers, and with the severity of coronary artery disease. The results add to the knowledge on the role of miR-146a in TNF-α-based inflammation in SCAD and support future research on the potential therapeutic use of miR-146a in such a clinical scenario.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent364298
dc.identifier.doi10.3390/medicina57060575
dc.identifier.issn1010-660X
dc.identifier.otherPURE: 32313353
dc.identifier.otherPURE UUID: b2cf8726-2819-4684-b127-12e0b2aabf68
dc.identifier.otherScopus: 85108199665
dc.identifier.otherWOS: 000666297400001
dc.identifier.urihttp://hdl.handle.net/10362/120549
dc.identifier.urlhttps://www.scopus.com/pages/publications/85108199665
dc.language.isoeng
dc.peerreviewedyes
dc.subjectInflammation
dc.subjectMicroRNA
dc.subjectMiR-146a
dc.subjectStable coronary artery disease
dc.subjectTumor necrosis factor alpha
dc.subjectGeneral Medicine
dc.subjectSDG 3 - Good Health and Well-being
dc.titleAssociation between mir-146a and tumor necrosis factor alpha (Tnf-α) in stable coronary artery diseaseen
dc.typejournal article
degois.publication.issue6
degois.publication.titleMedicina (Lithuania)
degois.publication.volume57
dspace.entity.typePublication
person.familyNamePereira-da-Silva
person.familyNameMota Carmo
person.givenNameTiago
person.givenNameMiguel
person.identifier.orcid0000-0003-0467-2608
person.identifier.orcid0000-0001-6865-4332
person.identifier.scopus-author-id7004005362
rcaap.rightsopenAccess
relation.isAuthorOfPublication4c17c358-87c1-467d-82b3-91afa2999c2a
relation.isAuthorOfPublicationfd4b0895-e30a-4ffe-8784-0ba1105d55f6
relation.isAuthorOfPublication.latestForDiscovery4c17c358-87c1-467d-82b3-91afa2999c2a

Ficheiros

Principais
A mostrar 1 - 1 de 1
Miniatura
Nome:
medicina_57_00575.pdf
Tamanho:
355.76 KB
Formato:
Adobe Portable Document Format
Ver/Abrir

Coleções

NMS - Artigos em revista nacional com arbitragem científica