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Effect of multiple micronutrient supplements vs iron and folic acid supplements on neonatal mortality

2022-08Artigo científico Acesso aberto
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dc.contributor.authorGomes, Filomena
dc.contributor.authorAgustina, Rina
dc.contributor.authorBlack, Robert E.
dc.contributor.authorChristian, Parul
dc.contributor.authorDewey, Kathryn G.
dc.contributor.authorKraemer, Klaus
dc.contributor.authorShankar, Anuraj H.
dc.contributor.authorSmith, Emily
dc.contributor.authorTumilowicz, Alison
dc.contributor.authorBourassa, Megan W.
dc.contributor.institutionNOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
dc.contributor.pblCambridge University Press
dc.date.accessioned2022-06-03T22:31:29Z
dc.date.available2022-06-03T22:31:29Z
dc.date.issued2022-08
dc.descriptionPublisher Copyright: © The Authors 2022.
dc.description.abstractObjective Antenatal multiple micronutrient supplements (MMS) are a cost-effective intervention to reduce adverse pregnancy and birth outcomes. However, the current WHO recommendation on the use of antenatal MMS is conditional, partly due to concerns about the effect on neonatal mortality in a subgroup of studies comparing MMS with iron and folic acid supplements (IFA) containing 60 mg of iron. We aimed to assess the effect of MMS vs IFA on neonatal mortality stratified by iron dose in each supplement. Methods We updated the neonatal mortality analysis of the 2020 WHO guidelines using the generic inverse variance method and applied the random effects model to calculate the effect estimates of MMS vs. IFA on neonatal mortality in subgroups of trials (n=13) providing the same or different amounts of iron, i.e. MMS with 60 mg of iron vs IFA with 60 mg of iron; MMS with 30 mg of iron vs IFA with 30 mg of iron; MMS with 30 mg of iron vs IFA with 60 mg of iron; and MMS with 20 mg of iron vs IFA with 60 mg of iron. Results There were no statistically significant differences in neonatal mortality between MMS and IFA within any of the subgroups of trials. Analysis of MMS with 30 mg vs IFA with 60 mg of iron (7 trials, 14,114 participants), yielded a nonsignificant Risk Ratio (RR) of 1.12 (95% CI 0.83 to 1.50). Conclusion Neonatal mortality did not differ between MMS and IFA regardless of iron dose in either supplement.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent499315
dc.identifier.doi10.1017/S1368980022001008
dc.identifier.issn1368-9800
dc.identifier.otherPURE: 44303511
dc.identifier.otherPURE UUID: eaa46379-7102-46f7-9d84-7bb45b4ad4c8
dc.identifier.otherScopus: 85129936497
dc.identifier.otherPubMed: 35466910
dc.identifier.urihttp://hdl.handle.net/10362/139413
dc.identifier.urlhttps://www.scopus.com/pages/publications/85129936497
dc.language.isoeng
dc.peerreviewedyes
dc.subjectiron
dc.subjectKeywords:
dc.subjectmicronutrient supplements
dc.subjectneonatal mortality
dc.subjectpregnancy
dc.subjectMedicine (miscellaneous)
dc.subjectNutrition and Dietetics
dc.subjectPublic Health, Environmental and Occupational Health
dc.subjectSDG 3 - Good Health and Well-being
dc.titleEffect of multiple micronutrient supplements vs iron and folic acid supplements on neonatal mortalityen
dc.title.subtitleA reanalysis by iron doseen
dc.typejournal article
degois.publication.firstPage2317
degois.publication.issue8
degois.publication.lastPage2321
degois.publication.titlePublic Health Nutrition
degois.publication.volume25
dspace.entity.typePublication
rcaap.rightsopenAccess

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