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Effectiveness of switching between TNF inhibitors in patients with axial spondyloarthritis

2020-08-21Artigo científico Acesso aberto
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dc.contributor.authorManica, Santiago Rodrigues
dc.contributor.authorRodrigues Manica, Santiago
dc.contributor.authorSepriano, Alexandre
dc.contributor.authorSepriano, Alexandre
dc.contributor.authorPimentel-Santos, Fernando
dc.contributor.authorM. Pimentel-Santos, F.
dc.contributor.authorGouveia, Nélia
dc.contributor.authorGouveia, Nélia
dc.contributor.authorBarcelos, Anabela
dc.contributor.authorBarcelos, Anabela
dc.contributor.authorBranco, Jaime
dc.contributor.authorBranco, Jaime
dc.contributor.authorBernardes, Miguel
dc.contributor.authorFerreira, Raquel Miriam
dc.contributor.authorVieira-Sousa, Elsa
dc.contributor.authorBarreira, Sofia
dc.contributor.authorVinagre, Filipe
dc.contributor.authorRoque, Raquel
dc.contributor.authorSantos, Helena
dc.contributor.authorSantos, Helena
dc.contributor.authorMadeira, Nathalie
dc.contributor.authorRovisco, João
dc.contributor.authorDaniel, Alexandra
dc.contributor.authorRamiro, Sofia
dc.contributor.authorRamiro, Sofia
dc.contributor.institutionNOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
dc.contributor.institutionCentro de Estudos de Doenças Crónicas (CEDOC)
dc.contributor.pblBioMed Central (BMC)
dc.date.accessioned2020-09-09T02:37:28Z
dc.date.available2020-09-09T02:37:28Z
dc.date.issued2020-08-21
dc.description57763]. AS is supported by a doctoral grant from “Fundação para a Ciência e Tecnologia” (SFRH/BD/108246/2015).
dc.description.abstractBackground: To investigate whether the reason to discontinue the first TNF inhibitor (TNFi) affects the response to the second TNFi in axial spondyloarthritis (axSpA). Methods: Patients with axSpA from the Rheumatic Diseases Portuguese Register (ReumaPt), who discontinued their first TNFi and started the second TNFi between June 2008 and May 2018, were included. Response was assessed by the Ankylosing Spondylitis Disease Activity Score (ASDAS) clinically important improvement (ASDAS-CII), major important improvement (ASDAS-MI), low disease activity (ASDAS-LDA), and inactive disease (ASDAS-ID). The reason for discontinuation of the first TNFi was defined, according to ASDAS-CII as primary failure (no response ≤ 6 months), secondary failure (response ≤ 6 months but lost thereafter), adverse events, and others. The association between the reason for discontinuation of the first TNFi and response to the second TNFi over time was assessed in multivariable generalized equation (GEE) models. Results: In total, 193 patients were included. The reason for discontinuation of the first TNFi did not influence the response to the second TNFi, according to the ASDAS-CII. However, a difference was found with more stringent outcomes, e.g., there was a higher likelihood to achieve ASDAS-ID with the second TNFi for patients discontinuing the first TNFi due to secondary failure (OR 7.3 [95%CI 1.9; 27.7]), adverse events (OR 9.1 [2.5; 33.3]), or other reasons (OR 7.7 [1.6; 37.9]) compared to primary failure. Conclusion: Patients with axSpA with secondary failure to their first TNFi, compared to those with primary failure, have a better response to the second TNFi according to stringent outcomes.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent525147
dc.identifier.doi10.1186/s13075-020-02288-8
dc.identifier.issn1478-6354
dc.identifier.otherPURE: 19742660
dc.identifier.otherPURE UUID: 2ae58445-c4f9-42ef-9800-ebc737c145e1
dc.identifier.otherScopus: 85089794409
dc.identifier.otherPubMed: 32825839
dc.identifier.otherWOS: 000565680600001
dc.identifier.urihttp://hdl.handle.net/10362/103791
dc.identifier.urlhttps://www.scopus.com/pages/publications/85089794409
dc.language.isoeng
dc.peerreviewedyes
dc.relationFunding This work was supported by a research grant from Merck Sharp & Dohme Corp., a division of Merck & Co., Inc., Kenilworth, NJ, USA [IIS
dc.subjectAnkylosing spondylitis
dc.subjectAS
dc.subjectaxSpA
dc.subjectbDMARD
dc.subjectnr-axSpA
dc.subjectr-axSpA
dc.subjectSpondyloarthritis
dc.subjectSwitch
dc.subjectTNFi
dc.subjectTreatment
dc.subjectRheumatology
dc.subjectImmunology and Allergy
dc.subjectImmunology
dc.titleEffectiveness of switching between TNF inhibitors in patients with axial spondyloarthritisen
dc.title.subtitleIs the reason to switch relevant?en
dc.typejournal article
degois.publication.issue1
degois.publication.titleArthritis Research & Therapy
degois.publication.volume22
dspace.entity.typePublication
person.familyNameRodrigues Manica
person.familyNameSepriano
person.familyNamePimentel-Santos
person.familyNameGouveia
person.familyNameBarcelos
person.familyNameBranco
person.familyNameSantos Cabrita Carneiro
person.familyNameRamiro
person.givenNameSantiago
person.givenNameAlexandre
person.givenNameFernando
person.givenNameNélia
person.givenNameAnabela
person.givenNameJaime
person.givenNameHelena Cristina
person.givenNameSofia
person.identifier1034753
person.identifier397398
person.identifier394707
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person.identifier.ciencia-idCE12-F61E-3227
person.identifier.ciencia-id3A17-D81C-F1AF
person.identifier.ciencia-idD217-657B-F89D
person.identifier.ciencia-idB612-E5C3-60DC
person.identifier.ciencia-id3712-D82D-C799
person.identifier.ciencia-idC513-D4F1-EEC3
person.identifier.orcid0000-0002-7217-0469
person.identifier.orcid0000-0003-1954-0229
person.identifier.orcid0000-0002-2816-7705
person.identifier.orcid0000-0003-4977-0367
person.identifier.orcid0000-0002-4116-8964
person.identifier.orcid0000-0001-7024-4375
person.identifier.orcid0000-0003-1396-8988
person.identifier.orcid0000-0002-8899-9087
person.identifier.ridQ-9612-2016
person.identifier.scopus-author-id55266526300
person.identifier.scopus-author-id35249227600
person.identifier.scopus-author-id23992116300
person.identifier.scopus-author-id8417815400
rcaap.rightsopenAccess
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