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Economic Evaluation of Individualized Nutritional Support for Hospitalized Patients with Chronic Heart Failure

2022-05-01Artigo científico Acesso aberto
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dc.contributor.authorSchuetz, Philipp
dc.contributor.authorSulo, Suela
dc.contributor.authorWalzer, Stefan
dc.contributor.authorKrenberger, Sebastian
dc.contributor.authorStagna, Zeno
dc.contributor.authorGomes, Filomena
dc.contributor.authorMueller, Beat
dc.contributor.authorBrunton, Cory
dc.contributor.institutionNOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
dc.contributor.pblMDPI AG
dc.date.accessioned2022-05-09T22:36:48Z
dc.date.available2022-05-09T22:36:48Z
dc.date.issued2022-05-01
dc.descriptionFunding Information: The initial trial was funded by the Swiss National Science Foundation (SNSF) (PP00P3_ 150531) and the Research Council of the Kantonsspital Aarau (1410.000.058 and 1410.000.044). Abbott provided a grant (HA34) to cover expenses associated with the economic analysis. Publisher Copyright: © 2022 by the authors. Licensee MDPI, Basel, Switzerland.
dc.description.abstractBackground Malnutrition is a highly prevalent risk factor in hospitalized patients with chronic heart failure (CHF). A recent randomized trial found lower mortality and improved health outcomes when CHF patients with nutritional risk received individualized nutritional treatment. Objective To estimate the cost-effectiveness of individualized nutritional support in hospitalized patients with CHF. Methods This analysis used data from CHF patients at risk of malnutrition (N = 645) who were part of the Effect of Early Nutritional Therapy on Frailty, Functional Outcomes and Recovery of Undernourished Medical Inpatients Trial (EFFORT). Study patients with CHF were randomized into (i) an intervention group (individualized nutritional support to reach energy, protein, and micronutrient goals) or (ii) a control group (receiving standard hospital food). We used a Markov model with daily cycles (over a 6-month interval) to estimate hospital costs and health outcomes in the comparator groups, thus modeling cost-effectiveness ratios of nutritional interventions. Results With nutritional support, the modeled total additional cost over the 6-month interval was 15,159 Swiss Francs (SF). With an additional 5.77 life days, the overall incremental cost-effectiveness ratio for nutritional support vs. no nutritional support was 2625 SF per life day gained. In terms of complications, patients receiving nutritional support had a cost savings of 6214 SF and an additional 4.11 life days without complications, yielding an incremental cost-effectiveness ratio for avoided complications of 1513 SF per life day gained. Conclusions On the basis of a Markov model, this economic analysis found that in-hospital nutritional support for CHF patients increased life expectancy at an acceptable incremental cost-effectiveness ratio.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent526924
dc.identifier.doi10.3390/nu14091703
dc.identifier.issn1422-8599
dc.identifier.otherPURE: 43619418
dc.identifier.otherPURE UUID: 016ab3dd-f05b-40d4-9298-2e1022d0cde9
dc.identifier.otherScopus: 85128519329
dc.identifier.otherPubMed: 35565669
dc.identifier.urihttp://hdl.handle.net/10362/137668
dc.identifier.urlhttps://www.scopus.com/pages/publications/85128519329
dc.language.isoeng
dc.peerreviewedyes
dc.subjectchronic heart failure
dc.subjectclinical outcomes
dc.subjectcost savings
dc.subjecteconomic analysis
dc.subjectnutritional support
dc.subjectFood Science
dc.subjectNutrition and Dietetics
dc.subjectSDG 2 - Zero Hunger
dc.subjectSDG 3 - Good Health and Well-being
dc.titleEconomic Evaluation of Individualized Nutritional Support for Hospitalized Patients with Chronic Heart Failureen
dc.typejournal article
degois.publication.issue9
degois.publication.titleNutrients
degois.publication.volume14
dspace.entity.typePublication
rcaap.rightsopenAccess

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