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Abnormal p53 High-Grade Endometrioid Endometrial Cancer

2025-01Recensão Acesso aberto
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dc.contributor.authorCasanova, João
dc.contributor.authorBabiciu, Alexandru
dc.contributor.authorCasanova, Joao
dc.contributor.authorDuarte, Gonçalo S.
dc.contributor.authorda Costa, Ana Gomes
dc.contributor.authorBabiciu, Alexandru-romualdo
dc.contributor.authorSilvério Serra, Sofia
dc.contributor.authorCosta, Teresa
dc.contributor.authorDuarte, Gonçalo S
dc.contributor.authorCatarino, Ana
dc.contributor.authorLeitão, Mário M.
dc.contributor.authorLima, Jorge
dc.contributor.authorSilvério Serra, Sofia
dc.contributor.authorCosta, Teresa
dc.contributor.authorLima, Jorge
dc.contributor.institutionNOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
dc.contributor.institutionComprehensive Health Research Centre (CHRC) - pólo NMS
dc.contributor.pblMDPI - Multidisciplinary Digital Publishing Institute
dc.date.accessioned2025-01-16T21:22:23Z
dc.date.available2025-01-16T21:22:23Z
dc.date.issued2025-01
dc.descriptionPublisher Copyright: © 2024 by the authors.
dc.description.abstractObjective: Our primary objective was to evaluate the oncologic outcomes of patients with abnormal p53 FIGO grade 3 (high-grade) endometrioid endometrial cancer. As secondary objectives, we determined the global prevalence of abnormal p53 in grade 3 endometrioid endometrial carcinomas and the geographical variations. Methods: The following electronic databases were searched: PubMed/Medline, EMBASE, Cochrane Library, Scopus, and Web of Science. We followed the Meta-Analysis for Observational Studies in Epidemiology guidelines and the Preferred Reporting Items for Systematic Reviews and Meta-Analyses. This review was preregistered with PROSPERO (no: CRD42023495192). Bias was assessed using the Quality in Prognosis Studies tool. For time-to-event data, the effect of p53 status on grade 3 endometrial cancer was described using hazard ratios (HRs) and corresponding 95% confidence intervals (CIs). Overall survival and progression-free survival were analyzed using one- and two-stage approaches, the Kaplan–Meier method, and Cox proportional hazards models. Results: Fifty-seven studies with 2528 patients were included. Patients with abnormal p53 had an increased risk of death (HR, 1.29 (95% CI, 1.11–1.48); I2 = 88%) and disease progression (HR, 1.63; 95% CI, 1.42–1.88; I2 = 2%) compared with patients with wildtype p53 G3 endometrial cancer. The global pooled prevalence of abnormal p53 was 30% (95% CI, 25–34%; tau2 = 0.02; I2 = 74%), with the highest prevalence being found in studies conducted in Asia (95% CI, 27–41%; tau2 = 0.01; I2 = 52%). Conclusions: Abnormal p53 grade 3 endometrioid endometrial cancer is more common in Asia, and it is associated with decreased overall survival and progression-free survival.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent2469984
dc.identifier.doi10.3390/cancers17010038
dc.identifier.issn2072-6694
dc.identifier.otherPURE: 106837137
dc.identifier.otherPURE UUID: 31599b1a-1514-4de6-8481-169fefe2609b
dc.identifier.otherScopus: 85214452426
dc.identifier.otherPubMed: 39796669
dc.identifier.urihttp://hdl.handle.net/10362/177549
dc.identifier.urlhttps://www.scopus.com/pages/publications/85214452426
dc.language.isoeng
dc.peerreviewedyes
dc.subjectendometrial cancer
dc.subjecthigh-grade endometrioid
dc.subjectmeta-analysis
dc.subjectoverall survival
dc.subjectp53
dc.subjectprevalence
dc.subjectprogression-free survival
dc.subjectsystematic review
dc.subjectOncology
dc.subjectCancer Research
dc.subjectSDG 3 - Good Health and Well-being
dc.titleAbnormal p53 High-Grade Endometrioid Endometrial Canceren
dc.title.subtitleA Systematic Review and Meta-Analysisen
dc.typereview
degois.publication.issue1
degois.publication.titleCancers
degois.publication.volume17
dspace.entity.typePublication
person.familyNameCasanova
person.familyNameBabiciu
person.familyNameDuarte
person.familyNameSilvério Serra
person.familyNameCosta
person.familyNameLima
person.givenNameJoao
person.givenNameAlexandru-romualdo
person.givenNameGonçalo
person.givenNameSofia Margarida
person.givenNameTeresa
person.givenNameJorge
person.identifier390958
person.identifier.ciencia-idB81A-7820-D655
person.identifier.ciencia-idFE1A-9376-3870
person.identifier.ciencia-idBD15-7953-5433
person.identifier.orcid0000-0002-2427-2137
person.identifier.orcid0009-0008-9711-9564
person.identifier.orcid0000-0001-7802-1897
person.identifier.orcid0000-0002-8953-4126
person.identifier.orcid0000-0003-4928-9047
person.identifier.orcid0000-0002-0831-2741
person.identifier.ridL-4920-2015
person.identifier.ridA-1133-2012
person.identifier.ridG-7629-2014
person.identifier.scopus-author-id57188702245
person.identifier.scopus-author-id57209881696
person.identifier.scopus-author-id57191927679
rcaap.rightsopenAccess
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relation.isAuthorOfPublication50fe6f92-0e2d-4936-800e-041002111f98
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relation.isAuthorOfPublication.latestForDiscoveryb72d0462-498c-4454-8016-2dad1dc6f9dd

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